Basic Information:

  VIRBase ID:  

HHID00065731

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30b-3p:  MIMAT0004589          FZR1:  NM_001136197     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30b-3p	FZR1
miRBase Accession/Entrez ID	MIMAT0004589	51343
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC20C//CDH1//FZR//FZR2//HCDH//HCDH1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30b-3p	rs1160794252 chr8:134800541    A/G rs761170520 chr8:134800545    A/C rs776207215 chr8:134800535    G/GT rs1293522812 chr8:134800547    C/T rs1407185230 chr8:134800550    C/T rs1435060162 chr8:134800546    C/T rs766838703 chr8:134800548    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FZR1	chr19:3517329(+) A-I      intronic chr19:3517332(+) A-I      intronic chr19:3517322(+) A-I      intronic chr19:3522012(+) A-I      intronic chr19:3521521(+) A-I      intronic chr19:3521519(+) A-I      intronic chr19:3518330(+) A-I      intronic chr19:3518142(+) A-I      intronic chr19:3518130(+) A-I      intronic chr19:3518113(+) A-I      intronic chr19:3518146(+) A-I      intronic chr19:3517536(+) A-I      intronic chr19:3517523(+) A-I      intronic chr19:3517178(+) A-I      intronic chr19:3521948(+) A-I      intronic chr19:3517126(+) A-I      intronic chr19:3515721(+) A-I      intronic chr19:3518044(+) A-I      intronic chr19:3518074(+) A-I      intronic chr19:3518106(+) A-I      intronic chr19:3515709(+) A-I      intronic chr19:3510307(+) A-I      intronic chr19:3518803(+) A-I      intronic chr19:3517618(+) A-I      intronic chr19:3518195(+) A-I      intronic chr19:3518850(+) A-I      intronic chr19:3517363(+) A-I      intronic chr19:3518301(+) A-I      intronic chr19:3522022(+) A-I      intronic chr19:3522017(+) A-I      intronic chr19:3518751(+) A-I      intronic chr19:3515512(+) A-I      intronic chr19:3518808(+) A-I      intronic chr19:3518298(+) A-I      intronic chr19:3518755(+) A-I      intronic chr19:3518246(+) A-I      intronic chr19:3521876(+) A-I      intronic chr19:3517566(+) A-I      intronic chr19:3521924(+) A-I      intronic chr19:3510198(+) A-I      intronic chr19:3517583(+) A-I      intronic chr19:3518259(+) A-I      intronic chr19:3517209(+) A-I      intronic chr19:3518251(+) A-I      intronic chr19:3517520(+) A-I      intronic chr19:3515644(+) A-I      intronic chr19:3517229(+) A-I      intronic chr19:3518241(+) A-I      intronic chr19:3517508(+) A-I      intronic chr19:3533943(+) A-I      intronic chr19:3517928(+) A-I      intronic chr19:3518202(+) A-I      intronic chr19:3517159(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FZR1	chr19:3518221(+) A-G intron -    22484847 chr19:3518241(+) A-G intron -    22484847 chr19:3518246(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FZR1	chr19:3506338-3506339(+) m6A 5'UTR       24209618//24981863 chr19:3522991-3522992(+) m6A CDS//exon       24284625//24209618 chr19:3522997-3522998(+) m6A CDS//exon       24284625//24209618 chr19:3523042-3523043(+) m6A CDS//exon       24284625//24209618 chr19:3525883-3525884(+) m6A CDS//exon       24284625//24209618 chr19:3525932-3525933(+) m6A CDS//exon       24284625//24981863 chr19:3525974-3525975(+) m6A CDS//exon       24284625//24981863 chr19:3526142-3526143(+) m6A CDS//exon       24284625//24981863 chr19:3526169-3526170(+) m6A CDS//exon       24284625//24981863 chr19:3526322-3526323(+) m6A CDS//exon       - chr19:3526330-3526331(+) m6A CDS//exon       24284625 chr19:3526337-3526338(+) m6A CDS//exon       24284625 chr19:3527655-3527656(+) m6A CDS//exon//intron       24284625 chr19:3527738-3527739(+) m6A CDS//exon//intron       24284625 chr19:3530823-3530824(+) m6A CDS//exon       24284625//22575960 chr19:3531715-3531716(+) m6A CDS//exon       24284625//24209618//22575960 chr19:3531777-3531778(+) m1A CDS       26863410 chr19:3531974-3531975(+) m6A CDS       24284625//24209618 chr19:3532055-3532056(+) m6A CDS       24284625 chr19:3532562-3532563(+) m6A CDS//exon//intron       24284625 chr19:3532575-3532576(+) m6A CDS//exon       24284625 chr19:3533316-3533317(+) m6A 3'UTR//CDS//exon       24284625 chr19:3534466-3534467(+) m6A 3'UTR//CDS//exon       24284625 chr19:3534496-3534497(+) m6A 3'UTR//CDS//exon       24284625 chr19:3534834-3534835(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3534848-3534849(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3534880-3534881(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3534904-3534905(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535003-3535004(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535043-3535044(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535087-3535088(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535112-3535113(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535147-3535148(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535206-3535207(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535226-3535227(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535267-3535268(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535307-3535308(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535314-3535315(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535331-3535332(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535398-3535399(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535578-3535579(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535596-3535597(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535601-3535602(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535607-3535608(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535712-3535713(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:3535845-3535846(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr19:3536373-3536374(+) m6A 3'UTR       24981863 chr19:3536600-3536601(+) m6A 3'UTR       24284625 chr19:3536607-3536608(+) m6A 3'UTR       24284625 chr19:3536689-3536690(+) m6A 3'UTR       24284625 chr19:3536735-3536736(+) m6A 3'UTR       24284625 chr19:3536760-3536761(+) m6A 3'UTR       24284625 chr19:3536965-3536966(+) m6A 3'UTR       - chr19:3536970-3536971(+) m6A 3'UTR       - chr19:3537108-3537109(+) m6A 3'UTR       - chr19:3537204-3537205(+) m6A 3'UTR       24284625 chr19:3537485-3537486(+) m6A 3'UTR       24209618 chr19:3537579-3537580(+) m6A 3'UTR       25456834 chr19:3537767-3537768(+) m6A 3'UTR       24284625//24209618//25456834 chr19:3537776-3537777(+) m6A 3'UTR       24284625//24209618//25456834 chr19:3537805-3537806(+) m6A 3'UTR       24284625//24209618 chr19:3537818-3537819(+) m6A 3'UTR       24209618 chr19:3538021-3538022(+) m6A 3'UTR       24284625//24209618 chr19:3538075-3538076(+) m6A 3'UTR       24284625//24209618 chr19:3538152-3538153(+) m6A 3'UTR       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30b-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	FZR1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30b-3p
Interactor2: FZR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.