Basic Information:

  VIRBase ID:  

HHID00065718

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30b-3p:  MIMAT0004589          IRF9:  NM_001385400     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30b-3p	IRF9
miRBase Accession/Entrez ID	MIMAT0004589	10379
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IRF-9//ISGF3//ISGF3G//p48

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30b-3p	rs1160794252 chr8:134800541    A/G rs761170520 chr8:134800545    A/C rs776207215 chr8:134800535    G/GT rs1293522812 chr8:134800547    C/T rs1407185230 chr8:134800550    C/T rs1435060162 chr8:134800546    C/T rs766838703 chr8:134800548    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IRF9	chr14:24632894(+) A-I      intronic chr14:24632896(+) A-I      intronic chr14:24632885(+) A-I      intronic chr14:24632887(+) A-I      intronic chr14:24632926(+) A-I      intronic chr14:24632897(+) A-I      intronic chr14:24632949(+) A-I      intronic chr14:24632927(+) A-I      intronic chr14:24632882(+) A-I      intronic chr14:24632891(+) A-I      intronic chr14:24631930(+) A-I      intronic chr14:24632943(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IRF9	chr14:24635562(+) T-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IRF9	chr14:24630400-24630401(+) m6A 5'UTR       25456834//24981863 chr14:24630439-24630440(+) m6A 5'UTR       25456834//24981863 chr14:24630445-24630446(+) m6A 5'UTR       25456834//24981863 chr14:24630458-24630459(+) m6A 5'UTR       25456834//24981863 chr14:24630535-24630536(+) m6A 5'UTR//exon       25456834//24981863 chr14:24631385-24631386(+) m6A CDS//exon//intron       24209618//24981863 chr14:24631393-24631394(+) m6A CDS//exon//intron       24209618//24981863 chr14:24631458-24631459(+) m6A CDS//exon//intron       24209618//24981863 chr14:24631481-24631482(+) m6A CDS//exon//intron       24209618//24981863 chr14:24631498-24631499(+) m6A CDS//exon//intron       24209618 chr14:24631510-24631511(+) m6A CDS//exon//intron       24209618 chr14:24631549-24631550(+) m6A exon//intron       24209618 chr14:24632211-24632212(+) m6A 3'UTR//5'UTR//CDS//exon       24209618 chr14:24632237-24632238(+) m6A 3'UTR//5'UTR//CDS//exon       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30b-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	IRF9	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30b-3p
Interactor2: IRF9

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.