Detail Information

Basic Information:


  VIRBase ID:  

HHID00065395

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-199b-3p:           SLC39A6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-199b-3p SLC39A6
miRBase
Accession/Entrez ID		 MIMAT0004563 25800
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LIV-1//ZIP6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-199b-3p
rs1212521216 chr9:128244750    A/T
rs1238211865 chr9:128244753    G/C
rs1246397225 chr9:128244748    C/G
rs1246397225 chr9:128244748    C/T
rs1295297894 chr9:128244751    A/G
rs753705566 chr9:128244754    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC39A6
chr18:33701308(-) A-I      intronic
chr18:33701392(-) A-I      intronic
chr18:33701387(-) A-I      intronic
chr18:33701366(-) A-I      intronic
chr18:33701362(-) A-I      intronic
chr18:33701228(-) A-I      intronic
chr18:33701216(-) A-I      intronic
chr18:33701248(-) A-I      intronic
chr18:33701393(-) A-I      intronic
chr18:33707420(-) A-I      intronic
chr18:33690870(-) A-I      intronic
chr18:33690617(-) A-I      intronic
chr18:33701192(-) A-I      intronic
chr18:33690920(-) A-I      intronic
chr18:33699761(-) A-I      intronic
chr18:33690871(-) A-I      intronic
chr18:33707864(-) A-I      intronic
chr18:33690914(-) A-I      intronic
chr18:33699749(-) A-I      intronic
chr18:33701284(-) A-I      intronic
chr18:33701257(-) A-I      intronic
chr18:33690623(-) A-I      intronic
chr18:33707465(-) A-I      intronic
chr18:33707831(-) A-I      intronic
chr18:33707445(-) A-I      intronic
chr18:33690842(-) A-I      intronic
chr18:33707776(-) A-I      intronic
chr18:33697091(-) A-I      intronic
chr18:33707393(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SLC39A6
chr18:33707864(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC39A6
chr18:33689207-33689208(-) m6A 3'UTR       27773535
chr18:33694187-33694188(-) m6A CDS       24981863//26404942//27773535
chr18:33704592-33704593(-) Y CDS       26075521
chr18:33706252-33706253(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr18:33706334-33706335(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706343-33706344(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706351-33706352(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706360-33706361(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706375-33706376(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706431-33706432(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706460-33706461(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:33706491-33706492(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr18:33706527-33706528(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr18:33706632-33706633(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085
chr18:33706650-33706651(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr18:33706668-33706669(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr18:33706876-33706877(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr18:33706901-33706902(-) m6A CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr18:33709094-33709095(-) m6A 5'UTR       24284625//24981863//27773535//27371828//27773536//22575960//22608085
chr18:33709120-33709121(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22575960
chr18:33709125-33709126(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22575960
chr18:33709139-33709140(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22575960
chr18:33709169-33709170(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22575960
chr18:33709207-33709208(-) m6A 5'UTR       24284625//24981863//27371828//27773536
chr18:33709232-33709233(-) m6A 5'UTR       24284625//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-199b-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Mast cells     -
Microvesicle Plasma     23077538
Microvesicle Breast cell line|Fibroblasts|Mesenchymal stem cells|Urine     -
SLC39A6
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-199b-3p
Emodin 3220 Drug interaction    RC00006898
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-199b-3p
Cisplatin 5702198       26261572
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-199b-3p
Interactor2: SLC39A6

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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