Detail Information

Basic Information:


  VIRBase ID:  

HHID00065375

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-199b-3p:           SPATA2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-199b-3p SPATA2
miRBase
Accession/Entrez ID		 MIMAT0004563 9825
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PD1//PPP1R145//tamo

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-199b-3p
rs1212521216 chr9:128244750    A/T
rs1238211865 chr9:128244753    G/C
rs1246397225 chr9:128244748    C/G
rs1246397225 chr9:128244748    C/T
rs1295297894 chr9:128244751    A/G
rs753705566 chr9:128244754    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPATA2
chr20:48528828(-) A-I      intronic
chr20:48525688(-) A-I      intronic
chr20:48525720(-) A-I      intronic
chr20:48525723(-) A-I      intronic
chr20:48528774(-) A-I      intronic
chr20:48525753(-) A-I      intronic
chr20:48523868(-) A-I      intronic
chr20:48526085(-) A-I      intronic
chr20:48526025(-) A-I      intronic
chr20:48527495(-) A-I      intronic
chr20:48523833(-) A-I      intronic
chr20:48528734(-) A-I      intronic
chr20:48525832(-) A-I      intronic
chr20:48525595(-) A-I      intronic
chr20:48526051(-) A-I      intronic
chr20:48525597(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SPATA2
chr20:48526025(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPATA2
chr20:48520113-48520114(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr20:48520191-48520192(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr20:48520694-48520695(-) m6A 3'UTR       24981863
chr20:48520917-48520918(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521019-48521020(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521041-48521042(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521055-48521056(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521080-48521081(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521209-48521210(-) m6A 3'UTR       24284625
chr20:48521460-48521461(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521502-48521503(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521569-48521570(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521615-48521616(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr20:48521635-48521636(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr20:48521742-48521743(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr20:48521769-48521770(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828
chr20:48521811-48521812(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr20:48522154-48522155(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr20:48522195-48522196(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr20:48522409-48522410(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr20:48522692-48522693(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr20:48522699-48522700(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr20:48522996-48522997(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr20:48523143-48523144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:48523164-48523165(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:48523252-48523253(-) m6A CDS       24284625//25456834//24981863//27773535//27371828
chr20:48523329-48523330(-) m6A CDS       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-199b-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Mast cells     -
Microvesicle Plasma     23077538
Microvesicle Breast cell line|Fibroblasts|Mesenchymal stem cells|Urine     -
SPATA2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-199b-3p
Emodin 3220 Drug interaction    RC00006898
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-199b-3p
Cisplatin 5702198       26261572
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-199b-3p
Interactor2: SPATA2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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