Detail Information

Basic Information:


  VIRBase ID:  

HHID00065329

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-199b-3p:           CFL2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-199b-3p CFL2
miRBase
Accession/Entrez ID		 MIMAT0004563 1073
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NEM7

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-199b-3p
rs1212521216 chr9:128244750    A/T
rs1238211865 chr9:128244753    G/C
rs1246397225 chr9:128244748    C/G
rs1246397225 chr9:128244748    C/T
rs1295297894 chr9:128244751    A/G
rs753705566 chr9:128244754    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CFL2
chr14:35179597-35179598(-) m6A 3'UTR       27773535
chr14:35179614-35179615(-) m6A 3'UTR       27773535
chr14:35181516-35181517(-) Y 3'UTR       26075521
chr14:35181827-35181828(-) m6A 3'UTR       26404942
chr14:35181863-35181864(-) m6A 3'UTR       26404942
chr14:35181892-35181893(-) m6A 3'UTR       26404942
chr14:35182079-35182080(-) m6A 3'UTR//CDS       24981863//26404942
chr14:35182118-35182119(-) Gm 3'UTR//CDS       -
chr14:35182137-35182138(-) m6A 3'UTR//CDS       24981863//26404942
chr14:35182175-35182176(-) m6A 3'UTR//CDS       24981863//26404942
chr14:35182477-35182478(-) m6A CDS//intron       27773535
chr14:35182499-35182500(-) m6A CDS//intron       27773535
chr14:35182573-35182574(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr14:35182635-35182636(-) m6A CDS//intron       24981863//27773535//22608085
chr14:35182942-35182943(-) m6A 5'UTR//intron       24981863//22608085
chr14:35182979-35182980(-) m6A 5'UTR//intron       24981863
chr14:35183934-35183935(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-199b-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Mast cells     -
Microvesicle Plasma     23077538
Microvesicle Breast cell line|Fibroblasts|Mesenchymal stem cells|Urine     -
CFL2
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-199b-3p
Emodin 3220 Drug interaction    RC00006898
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-199b-3p
Cisplatin 5702198       26261572
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-199b-3p
Interactor2: CFL2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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