Basic Information:

  VIRBase ID:  

HHID00065301

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196a-3p:  MIMAT0004562          MAPK1IP1L:  NM_144578     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-196a-3p	MAPK1IP1L
miRBase Accession/Entrez ID	MIMAT0004562	93487
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	c14_5346//C14orf32//MISS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-196a-3p	rs11614913 chr12:53991815    C/T rs1368718408 chr12:53991807    A/G rs746757166 chr12:53991820    G/A rs748322294 chr12:53991799    C/A rs748322294 chr12:53991799    C/T rs1180405062 chr12:53991805    C/A rs1416846667 chr12:53991804    A/G rs530949885 chr12:53991800    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAPK1IP1L	chr14:55527605(+) A-I      intronic chr14:55522568(+) A-I      intronic chr14:55522517(+) A-I      intronic chr14:55525515(+) A-I      intronic chr14:55525491(+) A-I      intronic chr14:55522494(+) A-I      intronic chr14:55522487(+) A-I      intronic chr14:55525399(+) A-I      intronic chr14:55525398(+) A-I      intronic chr14:55525393(+) A-I      intronic chr14:55521027(+) A-I      intronic chr14:55525353(+) A-I      intronic chr14:55524383(+) A-I      intronic chr14:55522465(+) A-I      intronic chr14:55522448(+) A-I      intronic chr14:55522484(+) A-I      intronic chr14:55522472(+) A-I      intronic chr14:55522471(+) A-I      intronic chr14:55525263(+) A-I      intronic chr14:55527654(+) A-I      intronic chr14:55526918(+) A-I      intronic chr14:55522453(+) A-I      intronic chr14:55525475(+) A-I      intronic chr14:55522528(+) A-I      intronic chr14:55522598(+) A-I      intronic chr14:55527775(+) A-I      intronic chr14:55522393(+) A-I      intronic chr14:55525430(+) A-I      intronic chr14:55524393(+) A-I      intronic chr14:55526909(+) A-I      intronic chr14:55527193(+) A-I      intronic chr14:55526989(+) A-I      intronic chr14:55521906(+) A-I      intronic chr14:55520956(+) A-I      intronic chr14:55527015(+) A-I      intronic chr14:55526101(+) A-I      intronic chr14:55521872(+) A-I      intronic chr14:55525505(+) A-I      intronic chr14:55526945(+) A-I      intronic chr14:55523393(+) A-I      intronic chr14:55522450(+) A-I      intronic chr14:55522439(+) A-I      intronic chr14:55523403(+) A-I      intronic chr14:55521001(+) A-I      intronic chr14:55521099(+) A-I      intronic chr14:55525388(+) A-I      intronic chr14:55526933(+) A-I      intronic chr14:55527597(+) A-I      intronic chr14:55526970(+) A-I      intronic chr14:55522379(+) A-I      intronic chr14:55527019(+) A-I      intronic chr14:55527793(+) A-I      intronic chr14:55520936(+) A-I      intronic chr14:55525293(+) A-I      intronic chr14:55527155(+) A-I      intronic chr14:55527600(+) A-I      intronic chr14:55527747(+) A-I      intronic chr14:55522605(+) A-I      intronic chr14:55523488(+) A-I      intronic chr14:55527599(+) A-I      intronic chr14:55521123(+) A-I      intronic chr14:55527778(+) A-I      intronic chr14:55526095(+) A-I      intronic chr14:55527007(+) A-I      intronic chr14:55524259(+) A-I      intronic chr14:55523357(+) A-I      intronic chr14:55521886(+) A-I      intronic chr14:55525342(+) A-I      intronic chr14:55525435(+) A-I      intronic chr14:55527167(+) A-I      intronic chr14:55524260(+) A-I      intronic chr14:55527047(+) A-I      intronic chr14:55524423(+) A-I      intronic chr14:55522473(+) A-I      intronic chr14:55521043(+) A-I      intronic chr14:55527766(+) A-I      intronic chr14:55527741(+) A-I      intronic chr14:55527132(+) A-I      intronic chr14:55527124(+) A-I      intronic chr14:55527055(+) A-I      intronic chr14:55524347(+) A-I      intronic chr14:55526125(+) A-I      intronic chr14:55525529(+) A-I      intronic chr14:55525456(+) A-I      intronic chr14:55525443(+) A-I      intronic chr14:55525439(+) A-I      intronic chr14:55525411(+) A-I      intronic chr14:55525403(+) A-I      intronic chr14:55525391(+) A-I      intronic chr14:55525372(+) A-I      intronic chr14:55525371(+) A-I      intronic chr14:55525362(+) A-I      intronic chr14:55524367(+) A-I      intronic chr14:55524322(+) A-I      intronic chr14:55524317(+) A-I      intronic chr14:55524316(+) A-I      intronic chr14:55524257(+) A-I      intronic chr14:55523449(+) A-I      intronic chr14:55523377(+) A-I      intronic chr14:55523364(+) A-I      intronic chr14:55522462(+) A-I      intronic chr14:55523302(+) A-I      intronic chr14:55523292(+) A-I      intronic chr14:55522542(+) A-I      intronic chr14:55522410(+) A-I      intronic chr14:55521135(+) A-I      intronic chr14:55521095(+) A-I      intronic chr14:55521017(+) A-I      intronic chr14:55520916(+) A-I      intronic chr14:55527045(+) A-I      intronic chr14:55527042(+) A-I      intronic chr14:55527874(+) A-I      intronic chr14:55521052(+) A-I      intronic chr14:55523503(+) A-I      intronic chr14:55525347(+) A-I      intronic chr14:55524363(+) A-I      intronic chr14:55522563(+) A-I      intronic chr14:55522399(+) A-I      intronic chr14:55525387(+) A-I      intronic chr14:55523297(+) A-I      intronic chr14:55523250(+) A-I      intronic chr14:55525553(+) A-I      intronic chr14:55523434(+) A-I      intronic chr14:55527854(+) A-I      intronic chr14:55527760(+) A-I      intronic chr14:55525389(+) A-I      intronic chr14:55527176(+) A-I      intronic chr14:55522567(+) A-I      intronic chr14:55524424(+) A-I      intronic chr14:55523416(+) A-I      intronic chr14:55527788(+) A-I      intronic chr14:55526964(+) A-I      intronic chr14:55527100(+) A-I      intronic chr14:55524299(+) A-I      intronic chr14:55527648(+) A-I      intronic chr14:55524222(+) A-I      intronic chr14:55525348(+) A-I      intronic chr14:55523426(+) A-I      intronic chr14:55521855(+) A-I      intronic chr14:55524328(+) A-I      intronic chr14:55525310(+) A-I      intronic chr14:55521920(+) A-I      intronic chr14:55526954(+) A-I      intronic chr14:55525299(+) A-I      intronic chr14:55524266(+) A-I      intronic chr14:55521028(+) A-I      intronic chr14:55525373(+) A-I      intronic chr14:55524243(+) A-I      intronic chr14:55527606(+) A-I      intronic chr14:55522434(+) A-I      intronic chr14:55525462(+) A-I      intronic chr14:55520949(+) A-I      intronic chr14:55525390(+) A-I      intronic chr14:55521096(+) A-I      intronic chr14:55523412(+) A-I      intronic chr14:55527670(+) A-I      intronic chr14:55520991(+) A-I      intronic chr14:55521919(+) A-I      intronic chr14:55522525(+) A-I      intronic chr14:55525471(+) A-I      intronic chr14:55521070(+) A-I      intronic chr14:55527674(+) A-I      intronic chr14:55527783(+) A-I      intronic chr14:55527078(+) A-I      intronic chr14:55524413(+) A-I      intronic chr14:55527016(+) A-I      intronic chr14:55527750(+) A-I      intronic chr14:55527796(+) A-I      intronic chr14:55522544(+) A-I      intronic chr14:55521932(+) A-I      intronic chr14:55523501(+) A-I      intronic chr14:55525427(+) A-I      intronic chr14:55527581(+) A-I      intronic chr14:55521100(+) A-I      intronic chr14:55522463(+) A-I      intronic chr14:55522527(+) A-I      intronic chr14:55521003(+) A-I      intronic chr14:55524221(+) A-I      intronic chr14:55521104(+) A-I      intronic chr14:55522533(+) A-I      intronic chr14:55521023(+) A-I      intronic chr14:55525452(+) A-I      intronic chr14:55527069(+) A-I      intronic chr14:55523369(+) A-I      intronic chr14:55523489(+) A-I      intronic chr14:55523267(+) A-I      intronic chr14:55525554(+) A-I      intronic chr14:55522394(+) A-I      intronic chr14:55525532(+) A-I      intronic chr14:55527729(+) A-I      intronic chr14:55523414(+) A-I      intronic chr14:55522603(+) A-I      intronic chr14:55526300(+) A-I      intronic chr14:55521060(+) A-I      intronic chr14:55523345(+) A-I      intronic chr14:55524213(+) A-I      intronic chr14:55525495(+) A-I      intronic chr14:55527169(+) A-I      intronic chr14:55527029(+) A-I      intronic chr14:55526953(+) A-I      intronic chr14:55523466(+) A-I      intronic chr14:55521063(+) A-I      intronic chr14:55521108(+) A-I      intronic chr14:55522597(+) A-I      intronic chr14:55525294(+) A-I      intronic chr14:55527075(+) A-I      intronic chr14:55525363(+) A-I      intronic chr14:55524420(+) A-I      intronic chr14:55522490(+) A-I      intronic chr14:55525470(+) A-I      intronic chr14:55522501(+) A-I      intronic chr14:55524554(+) A-I      intronic chr14:55525429(+) A-I      intronic chr14:55527092(+) A-I      intronic chr14:55527626(+) A-I      intronic chr14:55527104(+) A-I      intronic chr14:55524353(+) A-I      intronic chr14:55523308(+) A-I      intronic chr14:55526094(+) A-I      intronic chr14:55521937(+) A-I      intronic chr14:55526983(+) A-I      intronic chr14:55527645(+) A-I      intronic chr14:55522488(+) A-I      intronic chr14:55527774(+) A-I      intronic chr14:55522554(+) A-I      intronic chr14:55527031(+) A-I      intronic chr14:55523450(+) A-I      intronic chr14:55523367(+) A-I      intronic chr14:55526164(+) A-I      intronic chr14:55524297(+) A-I      intronic chr14:55521037(+) A-I      intronic chr14:55526148(+) A-I      intronic chr14:55524319(+) A-I      intronic chr14:55522537(+) A-I      intronic chr14:55527154(+) A-I      intronic chr14:55525302(+) A-I      intronic chr14:55522498(+) A-I      intronic chr14:55523248(+) A-I      intronic chr14:55523394(+) A-I      intronic chr14:55523409(+) A-I      intronic chr14:55522429(+) A-I      intronic chr14:55522402(+) A-I      intronic chr14:55527616(+) A-I      intronic chr14:55525396(+) A-I      intronic chr14:55524399(+) A-I      intronic chr14:55526220(+) A-I      intronic chr14:55524289(+) A-I      intronic chr14:55524205(+) A-I      intronic chr14:55524337(+) A-I      intronic chr14:55522373(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAPK1IP1L	chr14:55520949(+) A-I intron -    21960545   //22327324 chr14:55521043(+) A-I intron -    21960545   //22327324 chr14:55521872(+) A-I intron -    22327324 chr14:55521886(+) A-I intron -    22327324 chr14:55522525(+) A-I intron -    22327324 chr14:55522528(+) A-I intron -    22327324 chr14:55522563(+) A-I intron -    21960545   //22327324 chr14:55523357(+) A-I intron -    22327324 chr14:55523434(+) A-I intron -    22327324 chr14:55524205(+) A-I intron -    22327324 chr14:55524353(+) A-I intron -    22327324 chr14:55525294(+) A-I intron -    21960545   //22327324 chr14:55525430(+) A-I intron -    22327324 chr14:55525471(+) A-I intron -    22327324 chr14:55525475(+) A-I intron -    22327324 chr14:55525532(+) A-I intron -    22327324 chr14:55526101(+) A-I intron -    22327324 chr14:55527029(+) A-I intron -    22028664   //22327324 chr14:55527597(+) A-I intron -    22327324 chr14:55527600(+) A-I intron -    21960545   //22327324 chr14:55527606(+) A-I intron -    22327324 chr14:55527670(+) A-I intron -    22327324 chr14:55527674(+) A-I intron -    22327324 chr14:55527729(+) A-I intron -    21960545   //22327324 chr14:55527747(+) A-I intron -    22327324 chr14:55527775(+) A-I intron -    21960545   //22327324 chr14:55527788(+) A-I intron -    22327324 chr14:55526909(+) A-I intron -    22028664 chr14:55526918(+) A-I intron -    22028664 chr14:55526933(+) A-I intron -    22028664 chr14:55526945(+) A-I intron -    22028664 chr14:55526953(+) A-I intron -    22028664 chr14:55526954(+) A-I intron -    22028664 chr14:55526970(+) A-I intron -    22028664 chr14:55526983(+) A-I intron -    22028664 chr14:55526989(+) A-I intron -    22028664 chr14:55527007(+) A-I intron -    22028664 chr14:55527015(+) A-I intron -    22028664 chr14:55527016(+) A-I intron -    22028664 chr14:55527019(+) A-I intron -    22028664 chr14:55527031(+) A-I intron -    22028664 chr14:55527075(+) A-I intron -    22028664 chr14:55527100(+) A-I intron -    22028664 chr14:55527104(+) A-I intron -    22028664 chr14:55527155(+) A-I intron -    22028664 chr14:55527169(+) A-I intron -    22028664 chr14:55527193(+) A-I intron -    22028664 chr14:55521001(+) A-I intron -    21960545 chr14:55521003(+) A-I intron -    21960545 chr14:55521070(+) A-I intron -    21960545 chr14:55521099(+) A-I intron -    21960545 chr14:55521100(+) A-I intron -    21960545 chr14:55521104(+) A-I intron -    21960545 chr14:55522399(+) A-I intron -    21960545 chr14:55525293(+) A-I intron -    21960545 chr14:55525299(+) A-I intron -    21960545 chr14:55525427(+) A-I intron -    21960545 chr14:55525429(+) A-I intron -    21960545 chr14:55527599(+) A-I intron -    21960545 chr14:55527793(+) A-I intron -    21960545 chr14:55520991(+) A-I intron -    21960545 chr14:55521919(+) A-I intron -    21960545 chr14:55520895(+) C-T intron -    22484847 chr14:55520949(+) A-G intron -    22484847 chr14:55521001(+) A-G intron -    22484847 chr14:55521043(+) A-G intron -    22484847 chr14:55521100(+) A-G intron -    22484847 chr14:55521104(+) A-G intron -    22484847 chr14:55521872(+) A-G intron -    22484847 chr14:55521886(+) A-G intron -    22484847 chr14:55521919(+) A-G intron -    22484847 chr14:55521937(+) A-G intron -    22484847 chr14:55522429(+) A-G intron -    22484847 chr14:55522434(+) A-G intron -    22484847 chr14:55522450(+) A-G intron -    22484847 chr14:55522462(+) A-G intron -    22484847 chr14:55522488(+) A-G intron -    22484847 chr14:55522525(+) A-G intron -    22484847 chr14:55522528(+) A-G intron -    22484847 chr14:55522544(+) A-G intron -    22484847 chr14:55522563(+) A-G intron -    22484847 chr14:55522597(+) A-G intron -    22484847 chr14:55522598(+) A-G intron -    22484847 chr14:55523248(+) A-G intron -    22484847 chr14:55523297(+) A-G intron -    22484847 chr14:55523357(+) A-G intron -    22484847 chr14:55523367(+) A-G intron -    22484847 chr14:55523369(+) A-G intron -    22484847 chr14:55523393(+) A-G intron -    22484847 chr14:55523403(+) A-G intron -    22484847 chr14:55523409(+) A-G intron -    22484847 chr14:55523434(+) A-G intron -    22484847 chr14:55523501(+) A-G intron -    22484847 chr14:55524205(+) A-G intron -    22484847 chr14:55524221(+) A-G intron -    22484847 chr14:55524222(+) A-G intron -    22484847 chr14:55524243(+) A-G intron -    22484847 chr14:55524259(+) A-G intron -    22484847 chr14:55524266(+) A-G intron -    22484847 chr14:55524299(+) A-G intron -    22484847 chr14:55524319(+) A-G intron -    22484847 chr14:55524328(+) A-G intron -    22484847 chr14:55524337(+) A-G intron -    22484847 chr14:55524353(+) A-G intron -    22484847 chr14:55524424(+) A-G intron -    22484847 chr14:55525293(+) A-G intron -    22484847 chr14:55525294(+) A-G intron -    22484847 chr14:55525302(+) A-G intron -    22484847 chr14:55525387(+) A-G intron -    22484847 chr14:55525389(+) A-G intron -    22484847 chr14:55525427(+) A-G intron -    22484847 chr14:55525430(+) A-G intron -    22484847 chr14:55525471(+) A-G intron -    22484847 chr14:55525475(+) A-G intron -    22484847 chr14:55525495(+) A-G intron -    22484847 chr14:55525505(+) A-G intron -    22484847 chr14:55525527(+) G-C intron -    22484847 chr14:55525532(+) A-G intron -    22484847 chr14:55525554(+) A-G intron -    22484847 chr14:55526095(+) A-G intron -    22484847 chr14:55526101(+) A-G intron -    22484847 chr14:55526300(+) A-G intron -    22484847 chr14:55526983(+) A-G intron -    22484847 chr14:55527019(+) A-G intron -    22484847 chr14:55527029(+) A-G intron -    22484847 chr14:55527075(+) A-G intron -    22484847 chr14:55527100(+) A-G intron -    22484847 chr14:55527155(+) A-G intron -    22484847 chr14:55527169(+) A-G intron -    22484847 chr14:55527597(+) A-G intron -    22484847 chr14:55527599(+) A-G intron -    22484847 chr14:55527600(+) A-G intron -    22484847 chr14:55527606(+) A-G intron -    22484847 chr14:55527626(+) A-G intron -    22484847 chr14:55527670(+) A-G intron -    22484847 chr14:55527674(+) A-G intron -    22484847 chr14:55527729(+) A-G intron -    22484847 chr14:55527747(+) A-G intron -    22484847 chr14:55527750(+) A-G intron -    22484847 chr14:55527775(+) A-G intron -    22484847 chr14:55527778(+) A-G intron -    22484847 chr14:55527788(+) A-G intron -    22484847 chr14:55527793(+) A-G intron -    22484847 chr14:55527796(+) A-G intron -    22484847 chr14:55534216(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAPK1IP1L	chr14:55518475-55518476(+) m6A 5'UTR//exon       24284625//24981863//22575960 chr14:55518493-55518494(+) m6A 5'UTR//exon       24284625//24981863//22575960 chr14:55529355-55529356(+) m6A CDS//exon       24284625//24209618//24981863 chr14:55529371-55529372(+) m6A CDS//exon       24284625//24209618//24981863 chr14:55529394-55529395(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr14:55529472-55529473(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55529511-55529512(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55529553-55529554(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55529565-55529566(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55529592-55529593(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55529700-55529701(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr14:55529769-55529770(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr14:55529916-55529917(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr14:55529964-55529965(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55530006-55530007(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr14:55531455-55531456(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr14:55532226-55532227(+) m6A 3'UTR       24981863 chr14:55532338-55532339(+) m6A 3'UTR       24981863 chr14:55532545-55532546(+) Y 3'UTR       25219674

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-196a-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MAPK1IP1L	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-196a-3p
Interactor2: MAPK1IP1L

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.