Basic Information:

  VIRBase ID:  

HHID00065296

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196a-3p:  MIMAT0004562          PARD6B:  NM_032521     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-196a-3p	PARD6B
miRBase Accession/Entrez ID	MIMAT0004562	84612
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAR6B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-196a-3p	rs11614913 chr12:53991815    C/T rs1368718408 chr12:53991807    A/G rs746757166 chr12:53991820    G/A rs748322294 chr12:53991799    C/A rs748322294 chr12:53991799    C/T rs1180405062 chr12:53991805    C/A rs1416846667 chr12:53991804    A/G rs530949885 chr12:53991800    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PARD6B	chr20:49357637(+) A-I      intronic chr20:49353437(+) A-I      intronic chr20:49353395(+) A-I      intronic chr20:49351511(+) A-I      intronic chr20:49351320(+) A-I      intronic chr20:49355823(+) A-I      intronic chr20:49351024(+) A-I      intronic chr20:49355822(+) A-I      intronic chr20:49351022(+) A-I      intronic chr20:49351425(+) A-I      intronic chr20:49372363(+) A-I      intronic chr20:49365181(+) A-I      intronic chr20:49364638(+) A-I      intronic chr20:49364614(+) A-I      intronic chr20:49362305(+) A-I      intronic chr20:49360305(+) A-I      intronic chr20:49360170(+) A-I      intronic chr20:49358717(+) A-I      intronic chr20:49358660(+) A-I      intronic chr20:49358641(+) A-I      intronic chr20:49358629(+) A-I      intronic chr20:49355864(+) A-I      intronic chr20:49351454(+) A-I      intronic chr20:49355837(+) A-I      intronic chr20:49372439(+) A-I      intronic chr20:49372444(+) A-I      intronic chr20:49360315(+) A-I      intronic chr20:49355831(+) A-I      intronic chr20:49355819(+) A-I      intronic chr20:49355807(+) A-I      intronic chr20:49353418(+) A-I      intronic chr20:49353364(+) A-I      intronic chr20:49353312(+) A-I      intronic chr20:49353299(+) A-I      intronic chr20:49353291(+) A-I      intronic chr20:49351632(+) A-I      intronic chr20:49351608(+) A-I      intronic chr20:49351607(+) A-I      intronic chr20:49372434(+) A-I      intronic chr20:49360214(+) A-I      intronic chr20:49351293(+) A-I      intronic chr20:49353496(+) A-I      intronic chr20:49360217(+) A-I      intronic chr20:49351556(+) A-I      intronic chr20:49370830(+) A-I      intronic chr20:49350945(+) A-I      intronic chr20:49351567(+) A-I      intronic chr20:49353487(+) A-I      intronic chr20:49360237(+) A-I      intronic chr20:49357772(+) A-I      intronic chr20:49350937(+) A-I      intronic chr20:49365176(+) A-I      intronic chr20:49365786(+) A-I      intronic chr20:49349951(+) A-I      intronic chr20:49368157(+) A-I      3'UTR chr20:49364766(+) A-I      intronic chr20:49365603(+) A-I      intronic chr20:49360781(+) A-I      intronic chr20:49362318(+) A-I      intronic chr20:49365356(+) A-I      intronic chr20:49353308(+) A-I      intronic chr20:49365702(+) A-I      intronic chr20:49365291(+) A-I      intronic chr20:49365349(+) A-I      intronic chr20:49351501(+) A-I      intronic chr20:49362176(+) A-I      intronic chr20:49349776(+) A-I      intronic chr20:49361809(+) A-I      intronic chr20:49360171(+) A-I      intronic chr20:49360791(+) A-I      intronic chr20:49365721(+) A-I      intronic chr20:49355374(+) A-I      intronic chr20:49358764(+) A-I      intronic chr20:49351566(+) A-I      intronic chr20:49372457(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PARD6B	chr20:49349747(+) A-I intron -    21960545 chr20:49351017(+) A-I intron -    21960545 chr20:49351022(+) A-I intron -    21960545 chr20:49351241(+) A-I intron -    21960545 chr20:49351293(+) A-I intron -    21960545 chr20:49351567(+) A-I intron -    21960545 chr20:49355420(+) A-I intron -    21960545 chr20:49362282(+) A-I intron -    21960545 chr20:49362305(+) A-I intron -    21960545 chr20:49362306(+) A-I intron -    21960545 chr20:49365291(+) A-I intron -    21960545 chr20:49365349(+) A-G intron -    22484847 chr20:49365689(+) G-C intron -    22484847 chr20:49365702(+) A-G intron -    22484847 chr20:49365721(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PARD6B	chr20:49348327-49348328(+) m6A CDS       - chr20:49354434-49354435(+) m6A CDS       22608085 chr20:49354517-49354518(+) m6A CDS       24981863//22608085 chr20:49354529-49354530(+) m6A CDS       24981863//22608085 chr20:49366204-49366205(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366225-49366226(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366318-49366319(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366325-49366326(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366406-49366407(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr20:49366526-49366527(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366603-49366604(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366646-49366647(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366654-49366655(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366678-49366679(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366686-49366687(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366748-49366749(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366774-49366775(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366804-49366805(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366895-49366896(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366954-49366955(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366968-49366969(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366988-49366989(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367007-49367008(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367026-49367027(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367066-49367067(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367192-49367193(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr20:49367226-49367227(+) m6A 3'UTR//intron       24981863//22608085 chr20:49367307-49367308(+) m6A 3'UTR//intron       22608085 chr20:49367320-49367321(+) m6A 3'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-196a-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PARD6B	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-196a-3p
Interactor2: PARD6B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.