Detail Information

Basic Information:


  VIRBase ID:  

HHID00065293

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-196a-3p:           MED10:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-196a-3p MED10
miRBase
Accession/Entrez ID		 MIMAT0004562 84246
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - L6//NUT2//TRG20

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-196a-3p
rs11614913 chr12:53991815    C/T
rs1368718408 chr12:53991807    A/G
rs746757166 chr12:53991820    G/A
rs748322294 chr12:53991799    C/A
rs748322294 chr12:53991799    C/T
rs1180405062 chr12:53991805    C/A
rs1416846667 chr12:53991804    A/G
rs530949885 chr12:53991800    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MED10
chr5:6372463-6372464(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr5:6372507-6372508(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr5:6372519-6372520(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr5:6372556-6372557(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr5:6372580-6372581(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:6372664-6372665(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:6372687-6372688(-) m6A CDS//exon       24284625//24209618//27773535//22608085
chr5:6378543-6378544(-) m6A CDS//exon       24284625//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-196a-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
MED10
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-196a-3p
Interactor2: MED10

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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