Detail Information

Basic Information:


  VIRBase ID:  

HHID00065148

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-181a-2-3p:           MTPN:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-181a-2-3p MTPN
miRBase
Accession/Entrez ID		 MIMAT0004558 136319
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GCDP//V-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-181a-2-3p
rs1363525227 chr9:124692539    C/T
rs746980931 chr9:124692529    T/C
rs756888540 chr9:124692528    G/A
rs761470313 chr9:124692538    C/G
rs768412133 chr9:124692535    G/A
rs768412133 chr9:124692535    G/C
rs769301869 chr9:124692527    C/G
rs769301869 chr9:124692527    C/T
rs776520807 chr9:124692536    T/C
rs772245639 chr9:124692523    T/A
rs772245639 chr9:124692523    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MTPN
chr7:135614483-135614484(-) m6A 3'UTR       24284625
chr7:135614661-135614662(-) m6A 3'UTR       24284625
chr7:135662037-135662038(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536
chr7:135662069-135662070(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-181a-2-3p
Exosome Plasma     23663360
Exosome B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
MTPN
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-181a-2-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00006886
Gemcitabine 60750 Drug interaction    RC00006885
Temozolomide 5394 Drug interaction    RC00006883
Eloxatine 5310940 Drug interaction    RC00006888
Paclitaxel 36314 Drug interaction    RC00006884
5-Fluorouracil 3385 Drug interaction    RC00006882
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006881
Gefitinib 123631 Drug interaction    RC00006887
Interleukin 13 (IL-13) - Drug interaction    RC00006889
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-181a-2-3p
Cisplatin 5702198       26676926

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-181a-2-3p
Interactor2: MTPN

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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