Basic Information:

  VIRBase ID:  

HHID00065020

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-7-2-3p:  MIMAT0004554          ALDOA:  NM_184043     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-7-2-3p	ALDOA
miRBase Accession/Entrez ID	MIMAT0004554	226
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALDA//GSD12//HEL-S-87p

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-7-2-3p	rs747160976 chr15:88611915    T/C rs772151253 chr15:88611907    A/T rs1250455629 chr15:88611898    A/ACAAATCC rs1204890571 chr15:88611903    T/C rs1233166293 chr15:88611908    G/A rs1233166293 chr15:88611908    G/C rs748388180 chr15:88611897    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ALDOA	chr16:30067331(+) A-I      intronic chr16:30067358(+) A-I      intronic chr16:30067357(+) A-I      intronic chr16:30079813(+) A-I      intronic chr16:30074087(+) A-I      intronic chr16:30067356(+) A-I      intronic chr16:30079839(+) A-I      intronic chr16:30067361(+) A-I      intronic chr16:30067383(+) A-I      intronic chr16:30079803(+) A-I      intronic chr16:30069871(+) A-I      intronic chr16:30074058(+) A-I      intronic chr16:30079874(+) A-I      intronic chr16:30079853(+) A-I      intronic chr16:30079817(+) A-I      intronic chr16:30079849(+) A-I      intronic chr16:30074096(+) A-I      intronic chr16:30074068(+) A-I      intronic chr16:30074051(+) A-I      intronic chr16:30074041(+) A-I      intronic chr16:30073981(+) A-I      intronic chr16:30073439(+) A-I      intronic chr16:30073436(+) A-I      intronic chr16:30073364(+) A-I      intronic chr16:30073362(+) A-I      intronic chr16:30073359(+) A-I      intronic chr16:30071429(+) A-I      intronic chr16:30065590(+) A-I      intronic chr16:30065586(+) A-I      intronic chr16:30065573(+) A-I      intronic chr16:30073765(+) A-I      intronic chr16:30073759(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ALDOA	chr16:30066567-30066568(+) m6A 5'UTR//exon//intron       24284625 chr16:30075165-30075166(+) m6A 5'UTR//exon       22608085 chr16:30075252-30075253(+) m6A 5'UTR//exon       24284625//25456834//24981863//22608085 chr16:30075287-30075288(+) m6A 5'UTR//exon       24284625//25456834//24981863//22608085 chr16:30075329-30075330(+) m6A 5'UTR//exon       24284625//25456834//24981863//22608085 chr16:30075549-30075550(+) m6A 5'UTR//exon//intron       24981863//26404942 chr16:30075609-30075610(+) m6A 5'UTR//intron       24981863//26404942 chr16:30075631-30075632(+) m6A 5'UTR//intron       24981863 chr16:30076004-30076005(+) m6A 5'UTR//exon//intron       24981863 chr16:30076048-30076049(+) m6A 5'UTR//exon//intron       24981863 chr16:30076121-30076122(+) m6A exon//intron       24284625//24981863//27371828//27773536 chr16:30076664-30076665(+) m6A 5'UTR//intron       27773536 chr16:30076715-30076716(+) m6A 5'UTR//intron       27371828//27773536 chr16:30078344-30078345(+) m6A CDS//intron       26404942//22575960 chr16:30078556-30078557(+) m6A 5'UTR//CDS//exon       26404942//22575960 chr16:30078614-30078615(+) m1A CDS//exon       26863196 chr16:30078700-30078701(+) m6A exon//intron       22575960 chr16:30078809-30078810(+) m6A CDS//exon       22575960 chr16:30078821-30078822(+) m6A CDS//exon       22575960 chr16:30078869-30078870(+) m6A CDS//exon       22575960 chr16:30078904-30078905(+) m6A CDS//exon       22575960 chr16:30079970-30079971(+) m6A CDS//exon       22575960 chr16:30079996-30079997(+) m6A CDS//exon       22575960 chr16:30080008-30080009(+) m6A CDS//exon       22575960 chr16:30080027-30080028(+) m6A exon//intron       22575960 chr16:30080051-30080052(+) m6A exon//intron       22575960 chr16:30080090-30080091(+) m6A exon//intron       - chr16:30080215-30080216(+) Am CDS//exon       - chr16:30080226-30080227(+) m6A CDS//exon       26404942//22575960 chr16:30080672-30080673(+) m6A CDS//exon//intron       22575960 chr16:30080754-30080755(+) m6A exon//intron       22575960 chr16:30081309-30081310(+) m6A CDS//exon       26404942//22575960 chr16:30081393-30081394(+) m6A CDS//intron       22575960 chr16:30081717-30081718(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-7-2-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ALDOA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-7-2-3p
Interactor2: ALDOA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.