Basic Information:

  VIRBase ID:  

HHID00064986

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-7-1-3p:  MIMAT0004553          NBEAL2:  NM_001365116     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-7-1-3p	NBEAL2
miRBase Accession/Entrez ID	MIMAT0004553	23218
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BDPLT4//GPS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-7-1-3p	rs1419148287 chr9:83969783    T/C rs1463372700 chr9:83969781    T/G rs767086173 chr9:83969775    G/A rs772876693 chr9:83969780    CTG/C rs775309693 chr9:83969778    G/C rs1411851112 chr9:83969779    ACTGTGATTTGTTGT/A rs760333621 chr9:83969787    T/C rs767563035 chr9:83969791    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NBEAL2	chr3:47049345(+) A-I      NonSyn:Tyr->Cys chr3:47024903(+) A-I      intronic chr3:47024823(+) A-I      intronic chr3:47022768(+) A-I      intronic chr3:47024985(+) A-I      intronic chr3:47025535(+) A-I      intronic chr3:47024831(+) A-I      intronic chr3:47025588(+) A-I      intronic chr3:47025618(+) A-I      intronic chr3:47025587(+) A-I      intronic chr3:47024856(+) A-I      intronic chr3:47022762(+) A-I      intronic chr3:47022702(+) A-I      intronic chr3:47024869(+) A-I      intronic chr3:47022771(+) A-I      intronic chr3:47024983(+) A-I      intronic chr3:47024880(+) A-I      intronic chr3:47024900(+) A-I      intronic chr3:47024939(+) A-I      intronic chr3:47022877(+) A-I      intronic chr3:47025050(+) A-I      intronic chr3:47022680(+) A-I      intronic chr3:47022812(+) A-I      intronic chr3:47022661(+) A-I      intronic chr3:47024929(+) A-I      intronic chr3:47024912(+) A-I      intronic chr3:47025075(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NBEAL2	chr3:47024912(+) A-G intron -    22484847 chr3:47024929(+) A-G intron -    22484847 chr3:47025050(+) A-G intron -    22484847 chr3:47025556(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NBEAL2	chr3:47021177-47021178(+) m6A 5'UTR       24981863 chr3:47021215-47021216(+) m6A 5'UTR       24981863 chr3:47036725-47036726(+) m6A CDS       24284625//24981863 chr3:47036855-47036856(+) m6A CDS       24284625//24981863 chr3:47036862-47036863(+) m6A CDS       24284625//24981863 chr3:47037470-47037471(+) m6A CDS       - chr3:47037508-47037509(+) m6A CDS       - chr3:47041723-47041724(+) m6A CDS       24284625//24981863 chr3:47041877-47041878(+) m6A CDS       - chr3:47044562-47044563(+) m6A CDS       - chr3:47044759-47044760(+) m6A CDS       24981863 chr3:47044794-47044795(+) m6A CDS       - chr3:47045320-47045321(+) m6A CDS       - chr3:47045733-47045734(+) m6A CDS       - chr3:47045741-47045742(+) m6A CDS       - chr3:47047687-47047688(+) Gm CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-7-1-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	NBEAL2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-7-1-3p
Interactor2: NBEAL2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.