Detail Information

Basic Information:


  VIRBase ID:  

HHID00064909

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:           FBXO45:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30c-2-3p FBXO45
miRBase
Accession/Entrez ID		 MIMAT0004550 200933
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Fbx45

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30c-2-3p
rs1262929323 chr6:71376964    A/G
rs1413659455 chr6:71376968    T/C
rs1421032991 chr6:71376975    C/A
rs1421032991 chr6:71376975    C/G
rs1488181071 chr6:71376967    G/T
rs747913643 chr6:71376976    C/A
rs760276048 chr6:71376974    G/C
rs775896072 chr6:71376969    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FBXO45
chr3:196310779(+) A-I      intronic
chr3:196303282(+) A-I      intronic
chr3:196307146(+) A-I      intronic
chr3:196302249(+) A-I      intronic
chr3:196310701(+) A-I      intronic
chr3:196315112(+) A-I      3'UTR
chr3:196302763(+) A-I      intronic
chr3:196303384(+) A-I      intronic
chr3:196310688(+) A-I      intronic
chr3:196310789(+) A-I      intronic
chr3:196302250(+) A-I      intronic
chr3:196297855(+) A-I      intronic
chr3:196310727(+) A-I      intronic
chr3:196297370(+) A-I      intronic
chr3:196303315(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FBXO45
chr3:196314984(+) A-G intron -    21725310
chr3:196310688(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FBXO45
chr3:196296078-196296079(+) m6A CDS//intron       24209618
chr3:196296138-196296139(+) m6A CDS//intron       24209618
chr3:196304408-196304409(+) m6A 5'UTR//CDS       24981863//22608085
chr3:196304440-196304441(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr3:196304609-196304610(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr3:196311031-196311032(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:196311045-196311046(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:196311095-196311096(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311173-196311174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311212-196311213(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311248-196311249(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311284-196311285(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311295-196311296(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311311-196311312(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:196311542-196311543(+) m6A 3'UTR       24981863
chr3:196313011-196313012(+) m6A 3'UTR       27773535
chr3:196313046-196313047(+) m6A 3'UTR       27773535
chr3:196313075-196313076(+) m6A 3'UTR       27773535
chr3:196313193-196313194(+) m6A 3'UTR       27773535
chr3:196313232-196313233(+) m6A 3'UTR       27773535
chr3:196313238-196313239(+) m6A 3'UTR       27773535
chr3:196313260-196313261(+) m6A 3'UTR       27773535
chr3:196313726-196313727(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30c-2-3p
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FBXO45
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30c-2-3p
Gemcitabine 60750 Drug interaction    RC00006870
Eloxatine 5310940 Drug interaction    RC00006871
5-Fluorouracil 3385 Drug interaction    RC00006869
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30c-2-3p
Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30c-2-3p
Interactor2: FBXO45

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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