Basic Information:

  VIRBase ID:  

HHID00064902

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:  MIMAT0004550          LYPLAL1:  NM_001300771     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30c-2-3p	LYPLAL1
miRBase Accession/Entrez ID	MIMAT0004550	127018
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Q96AV0

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30c-2-3p	rs1262929323 chr6:71376964    A/G rs1413659455 chr6:71376968    T/C rs1421032991 chr6:71376975    C/A rs1421032991 chr6:71376975    C/G rs1488181071 chr6:71376967    G/T rs747913643 chr6:71376976    C/A rs760276048 chr6:71376974    G/C rs775896072 chr6:71376969    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LYPLAL1	chr1:219376238(+) A-I      intronic chr1:219376151(+) A-I      intronic chr1:219376043(+) A-I      intronic chr1:219376040(+) A-I      intronic chr1:219376145(+) A-I      intronic chr1:219376041(+) A-I      intronic chr1:219376157(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LYPLAL1	chr1:219383941(+) A-G exon CDS    21725310 chr1:219372963(+) C-T intron -    22484847 chr1:219376151(+) A-G intron -    22484847 chr1:219376157(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LYPLAL1	chr1:219347205-219347206(+) m6A 5'UTR       24981863 chr1:219347365-219347366(+) m6A exon//intron       24981863 chr1:219347628-219347629(+) m6A exon//intron       24981863 chr1:219348327-219348328(+) m6A exon//intron       24981863 chr1:219352498-219352499(+) m6A CDS//exon       24981863 chr1:219384923-219384924(+) m6A CDS//exon       27773535 chr1:219385001-219385002(+) m6A CDS//exon       24981863//27773535 chr1:219385011-219385012(+) m6A CDS//exon       24981863//27773535 chr1:219385060-219385061(+) m6A CDS//exon       24981863//27773535 chr1:219385152-219385153(+) Y 3'UTR//exon       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30c-2-3p	Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	LYPLAL1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30c-2-3p	Gemcitabine 60750 Drug interaction    RC00006870 Eloxatine 5310940 Drug interaction    RC00006871 5-Fluorouracil 3385 Drug interaction    RC00006869

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30c-2-3p	Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30c-2-3p
Interactor2: LYPLAL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.