Basic Information:

  VIRBase ID:  

HHID00064883

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:  MIMAT0004550          DDIT4:  NM_019058     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30c-2-3p	DDIT4
miRBase Accession/Entrez ID	MIMAT0004550	54541
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Dig2//REDD-1//REDD1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30c-2-3p	rs1262929323 chr6:71376964    A/G rs1413659455 chr6:71376968    T/C rs1421032991 chr6:71376975    C/A rs1421032991 chr6:71376975    C/G rs1488181071 chr6:71376967    G/T rs747913643 chr6:71376976    C/A rs760276048 chr6:71376974    G/C rs775896072 chr6:71376969    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDIT4	chr10:74033712-74033713(+) m6A 5'UTR//exon       24284625//22575960 chr10:74033879-74033880(+) m6A exon//intron       24284625//22575960 chr10:74033990-74033991(+) m6A CDS//exon       24284625//22575960 chr10:74034040-74034041(+) m6A CDS//exon       24284625//22575960 chr10:74034131-74034132(+) m6A CDS//exon       24284625//22575960 chr10:74034146-74034147(+) m6A CDS//exon       24284625//22575960 chr10:74034282-74034283(+) m6A exon//intron       24284625//22575960 chr10:74034336-74034337(+) m6A exon//intron       24981863//22575960 chr10:74034378-74034379(+) m6A exon//intron       24284625//24981863//22575960 chr10:74034516-74034517(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr10:74034636-74034637(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr10:74034791-74034792(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:74034808-74034809(+) Am CDS       - chr10:74034904-74034905(+) m1A CDS       26863410 chr10:74034921-74034922(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:74034946-74034947(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:74034981-74034982(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:74034995-74034996(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:74035010-74035011(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:74035031-74035032(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:74035052-74035053(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:74035139-74035140(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:74035168-74035169(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr10:74035400-74035401(+) m6A 3'UTR       24209618 chr10:74035642-74035643(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30c-2-3p	Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	DDIT4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30c-2-3p	Gemcitabine 60750 Drug interaction    RC00006870 Eloxatine 5310940 Drug interaction    RC00006871 5-Fluorouracil 3385 Drug interaction    RC00006869

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30c-2-3p	Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30c-2-3p
Interactor2: DDIT4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.