Detail Information

Basic Information:


  VIRBase ID:  

HHID00064876

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:           TPRKB:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30c-2-3p TPRKB
miRBase
Accession/Entrez ID		 MIMAT0004550 51002
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-121//CGI121//GAMOS5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30c-2-3p
rs1262929323 chr6:71376964    A/G
rs1413659455 chr6:71376968    T/C
rs1421032991 chr6:71376975    C/A
rs1421032991 chr6:71376975    C/G
rs1488181071 chr6:71376967    G/T
rs747913643 chr6:71376976    C/A
rs760276048 chr6:71376974    G/C
rs775896072 chr6:71376969    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TPRKB
chr2:73959596(-) A-I      intronic
chr2:73961030(-) A-I      intronic
chr2:73961219(-) A-I      intronic
chr2:73960464(-) A-I      intronic
chr2:73959594(-) A-I      intronic
chr2:73961017(-) A-I      intronic
chr2:73959582(-) A-I      intronic
chr2:73959688(-) A-I      intronic
chr2:73959687(-) A-I      intronic
chr2:73961112(-) A-I      intronic
chr2:73960559(-) A-I      intronic
chr2:73961485(-) A-I      intronic
chr2:73961363(-) A-I      intronic
chr2:73959668(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TPRKB
chr2:73959714(-) A-I intron -    15258596
chr2:73959749(-) A-I intron -    15258596
chr2:73959753(-) A-I intron -    15258596
chr2:73959797(-) A-I intron -    15258596
chr2:73961485(-) A-I intron -    22327324
chr2:73959588(-) A-G intron -    22484847
chr2:73959670(-) A-G intron -    22484847
chr2:73959714(-) A-G intron -    22484847
chr2:73961485(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TPRKB
chr2:73958073-73958074(-) m6A exon//intron       27773535
chr2:73958174-73958175(-) m6A exon//intron       27773535//27371828
chr2:73958233-73958234(-) m6A exon//intron       27773535//27371828
chr2:73958248-73958249(-) m6A exon//intron       27773535//27371828
chr2:73959037-73959038(-) m6A exon//intron       27371828
chr2:73961613-73961614(-) m6A CDS//exon//intron       24981863//27773535
chr2:73961673-73961674(-) m6A CDS//exon//intron       24981863//27773535
chr2:73964524-73964525(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30c-2-3p
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TPRKB
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30c-2-3p
Gemcitabine 60750 Drug interaction    RC00006870
Eloxatine 5310940 Drug interaction    RC00006871
5-Fluorouracil 3385 Drug interaction    RC00006869
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30c-2-3p
Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30c-2-3p
Interactor2: TPRKB

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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