Basic Information:

  VIRBase ID:  

HHID00064839

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:  MIMAT0004550          RRM2:  NR_164157     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30c-2-3p	RRM2
miRBase Accession/Entrez ID	MIMAT0004550	6241
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C2orf48//R2//RR2//RR2M

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30c-2-3p	rs1262929323 chr6:71376964    A/G rs1413659455 chr6:71376968    T/C rs1421032991 chr6:71376975    C/A rs1421032991 chr6:71376975    C/G rs1488181071 chr6:71376967    G/T rs747913643 chr6:71376976    C/A rs760276048 chr6:71376974    G/C rs775896072 chr6:71376969    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RRM2	chr2:10264372(+) A-I      intronic chr2:10264433(+) A-I      intronic chr2:10268121(+) A-I      intronic chr2:10268106(+) A-I      intronic chr2:10268082(+) A-I      intronic chr2:10268132(+) A-I      intronic chr2:10268134(+) A-I      intronic chr2:10268146(+) A-I      intronic chr2:10268186(+) A-I      intronic chr2:10268212(+) A-I      intronic chr2:10268237(+) A-I      intronic chr2:10268241(+) A-I      intronic chr2:10267801(+) A-I      intronic chr2:10267719(+) A-I      intronic chr2:10268242(+) A-I      intronic chr2:10268130(+) A-I      intronic chr2:10267782(+) A-I      intronic chr2:10268039(+) A-I      intronic chr2:10268131(+) A-I      intronic chr2:10267702(+) A-I      intronic chr2:10268116(+) A-I      intronic chr2:10267658(+) A-I      intronic chr2:10268047(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RRM2	chr2:10268249(+) A-I intron -    22327324 chr2:10264253(+) G-T intron -    22484847 chr2:10267658(+) A-G intron -    22484847 chr2:10267702(+) A-G intron -    22484847 chr2:10267719(+) A-G intron -    22484847 chr2:10267728(+) A-G intron -    22484847 chr2:10267782(+) A-G intron -    22484847 chr2:10267801(+) A-G intron -    22484847 chr2:10268039(+) A-G intron -    22484847 chr2:10268044(+) A-G intron -    22484847 chr2:10268047(+) A-G intron -    22484847 chr2:10268116(+) A-G intron -    22484847 chr2:10268130(+) A-G intron -    22484847 chr2:10268131(+) A-G intron -    22484847 chr2:10268133(+) A-G intron -    22484847 chr2:10268209(+) C-T intron -    22484847 chr2:10268213(+) A-G intron -    22484847 chr2:10268217(+) G-A intron -    22484847 chr2:10268242(+) A-G intron -    22484847 chr2:10268249(+) A-G intron -    22484847 chr2:10270878(+) T-C intron -    22484847 chr2:10270914(+) A-G intron -    22484847 chr2:10270959(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RRM2	chr2:10262962-10262963(+) m6A CDS//exon       24284625//22575960 chr2:10263019-10263020(+) m6A CDS//exon       24284625//22575960 chr2:10263127-10263128(+) m6A CDS//exon       24284625//22575960 chr2:10263441-10263442(+) m6A 5'UTR//intron       - chr2:10263516-10263517(+) m6A CDS//exon       - chr2:10263565-10263566(+) m6A CDS//exon       - chr2:10269249-10269250(+) m6A CDS//exon       27773535 chr2:10269265-10269266(+) m6A CDS//exon       27773535 chr2:10269376-10269377(+) m6A CDS//exon       27773535 chr2:10269417-10269418(+) m6A CDS//exon       24981863//27773535 chr2:10269517-10269518(+) m6A 3'UTR       24981863//27773535 chr2:10270978-10270979(+) m6A 3'UTR       - chr2:10271043-10271044(+) m6A 3'UTR       - chr2:10271442-10271443(+) m6A 3'UTR       27773535 chr2:10271469-10271470(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30c-2-3p	Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RRM2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30c-2-3p	Gemcitabine 60750 Drug interaction    RC00006870 Eloxatine 5310940 Drug interaction    RC00006871 5-Fluorouracil 3385 Drug interaction    RC00006869

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30c-2-3p	Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30c-2-3p
Interactor2: RRM2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.