Basic Information:

  VIRBase ID:  

HHID00064837

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:  MIMAT0004550          RAP2B:  NM_002886     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30c-2-3p	RAP2B
miRBase Accession/Entrez ID	MIMAT0004550	5912
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30c-2-3p	rs1262929323 chr6:71376964    A/G rs1413659455 chr6:71376968    T/C rs1421032991 chr6:71376975    C/A rs1421032991 chr6:71376975    C/G rs1488181071 chr6:71376967    G/T rs747913643 chr6:71376976    C/A rs760276048 chr6:71376974    G/C rs775896072 chr6:71376969    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAP2B	chr3:152880073-152880074(+) m6A 5'UTR       24209618//24981863//22575960 chr3:152880248-152880249(+) m6A 5'UTR       24209618//25456834//24981863//22575960 chr3:152880265-152880266(+) m6A 5'UTR       24209618//25456834//24981863//22575960 chr3:152880594-152880595(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:152880621-152880622(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:152880687-152880688(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:152880756-152880757(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:152880774-152880775(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr3:152880837-152880838(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:152880927-152880928(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:152880975-152880976(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:152881126-152881127(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:152881532-152881533(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:152881563-152881564(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:152881724-152881725(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:152881730-152881731(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:152882029-152882030(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr3:152882087-152882088(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr3:152882119-152882120(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:152882155-152882156(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:152882200-152882201(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30c-2-3p	Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RAP2B	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30c-2-3p	Gemcitabine 60750 Drug interaction    RC00006870 Eloxatine 5310940 Drug interaction    RC00006871 5-Fluorouracil 3385 Drug interaction    RC00006869

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30c-2-3p	Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30c-2-3p
Interactor2: RAP2B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.