Basic Information:

  VIRBase ID:  

HHID00064756

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          C2orf69:  NM_153689     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	C2orf69
miRBase Accession/Entrez ID	MIMAT0004518	205327
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C2orf69	chr2:200785558(+) A-I      intronic chr2:200785859(+) A-I      intronic chr2:200817807(+) A-I      intronic chr2:200785532(+) A-I      intronic chr2:200791372(+) A-I      3'UTR chr2:200791267(+) A-I      3'UTR chr2:200788952(+) A-I      intronic chr2:200788944(+) A-I      intronic chr2:200777635(+) A-I      intronic chr2:200786948(+) A-I      intronic chr2:200789063(+) A-I      intronic chr2:200789050(+) A-I      intronic chr2:200791258(+) A-I      3'UTR chr2:200789019(+) A-I      intronic chr2:200785869(+) A-I      intronic chr2:200777640(+) A-I      intronic chr2:200788999(+) A-I      intronic chr2:200785416(+) A-I      intronic chr2:200785991(+) A-I      intronic chr2:200785402(+) A-I      intronic chr2:200786855(+) A-I      intronic chr2:200789081(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C2orf69	chr2:200785402(+) A-G intron -    22484847 chr2:200785416(+) A-G intron -    22484847 chr2:200785869(+) A-G intron -    22484847 chr2:200791266(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C2orf69	chr2:200776139-200776140(+) m6A 5'UTR//exon       - chr2:200776254-200776255(+) m6A CDS//exon       - chr2:200776261-200776262(+) m6A CDS//exon       - chr2:200789833-200789834(+) m6A CDS//intron       24284625//22608085 chr2:200789978-200789979(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr2:200790088-200790089(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790159-200790160(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790298-200790299(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790304-200790305(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790333-200790334(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:200790417-200790418(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr2:200790629-200790630(+) m6A 3'UTR//intron       24981863//22608085 chr2:200790646-200790647(+) m6A 3'UTR//intron       22608085 chr2:200820138-200820139(+) m6A exon       24981863 chr2:200820228-200820229(+) m6A exon       24981863//27371828 chr2:200820269-200820270(+) m6A exon       25456834//24981863//27371828 chr2:200820306-200820307(+) m6A exon       25456834//24981863//27371828//27773536 chr2:200820596-200820597(+) m6A exon       24284625//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	C2orf69	Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: C2orf69

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.