Basic Information:

  VIRBase ID:  

HHID00064748

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          DCP2:  NM_001242377     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	DCP2
miRBase Accession/Entrez ID	MIMAT0004518	167227
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NUDT20

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCP2	chr5:112347926(+) A-I      intronic chr5:112346171(+) A-I      intronic chr5:112346030(+) A-I      intronic chr5:112345816(+) A-I      intronic chr5:112345804(+) A-I      intronic chr5:112343374(+) A-I      intronic chr5:112343356(+) A-I      intronic chr5:112343355(+) A-I      intronic chr5:112343282(+) A-I      intronic chr5:112343273(+) A-I      intronic chr5:112343250(+) A-I      intronic chr5:112343227(+) A-I      intronic chr5:112343184(+) A-I      intronic chr5:112342675(+) A-I      intronic chr5:112341696(+) A-I      intronic chr5:112340776(+) A-I      intronic chr5:112340668(+) A-I      intronic chr5:112340578(+) A-I      intronic chr5:112339238(+) A-I      intronic chr5:112339162(+) A-I      intronic chr5:112338406(+) A-I      intronic chr5:112338402(+) A-I      intronic chr5:112338383(+) A-I      intronic chr5:112338354(+) A-I      intronic chr5:112338287(+) A-I      intronic chr5:112338039(+) A-I      intronic chr5:112338000(+) A-I      intronic chr5:112337973(+) A-I      intronic chr5:112335924(+) A-I      intronic chr5:112335916(+) A-I      intronic chr5:112335894(+) A-I      intronic chr5:112335593(+) A-I      intronic chr5:112335484(+) A-I      intronic chr5:112335208(+) A-I      intronic chr5:112335192(+) A-I      intronic chr5:112333411(+) A-I      intronic chr5:112329235(+) A-I      intronic chr5:112329234(+) A-I      intronic chr5:112329160(+) A-I      intronic chr5:112324139(+) A-I      intronic chr5:112324134(+) A-I      intronic chr5:112324078(+) A-I      intronic chr5:112324074(+) A-I      intronic chr5:112323999(+) A-I      intronic chr5:112323964(+) A-I      intronic chr5:112323946(+) A-I      intronic chr5:112323925(+) A-I      intronic chr5:112323414(+) A-I      intronic chr5:112323410(+) A-I      intronic chr5:112342676(+) A-I      intronic chr5:112335205(+) A-I      intronic chr5:112323393(+) A-I      intronic chr5:112323392(+) A-I      intronic chr5:112323354(+) A-I      intronic chr5:112323351(+) A-I      intronic chr5:112323267(+) A-I      intronic chr5:112322482(+) A-I      intronic chr5:112322099(+) A-I      intronic chr5:112335246(+) A-I      intronic chr5:112344621(+) A-I      intronic chr5:112348420(+) A-I      intronic chr5:112347930(+) A-I      intronic chr5:112342630(+) A-I      intronic chr5:112346109(+) A-I      intronic chr5:112335143(+) A-I      intronic chr5:112335460(+) A-I      intronic chr5:112338472(+) A-I      intronic chr5:112343357(+) A-I      intronic chr5:112347906(+) A-I      intronic chr5:112338285(+) A-I      intronic chr5:112320453(+) A-I      intronic chr5:112322085(+) A-I      intronic chr5:112343237(+) A-I      intronic chr5:112341672(+) A-I      intronic chr5:112323229(+) A-I      intronic chr5:112335500(+) A-I      intronic chr5:112335890(+) A-I      intronic chr5:112342568(+) A-I      intronic chr5:112323371(+) A-I      intronic chr5:112324117(+) A-I      intronic chr5:112343304(+) A-I      intronic chr5:112345634(+) A-I      intronic chr5:112344680(+) A-I      intronic chr5:112335651(+) A-I      intronic chr5:112342556(+) A-I      intronic chr5:112322093(+) A-I      intronic chr5:112322660(+) A-I      intronic chr5:112323996(+) A-I      intronic chr5:112338262(+) A-I      intronic chr5:112352678(+) A-I      3'UTR chr5:112352639(+) A-I      3'UTR chr5:112337958(+) A-I      intronic chr5:112345809(+) A-I      intronic chr5:112348415(+) A-I      intronic chr5:112342684(+) A-I      intronic chr5:112335083(+) A-I      intronic chr5:112335999(+) A-I      intronic chr5:112329112(+) A-I      intronic chr5:112347936(+) A-I      intronic chr5:112322149(+) A-I      intronic chr5:112342741(+) A-I      intronic chr5:112338297(+) A-I      intronic chr5:112342688(+) A-I      intronic chr5:112345829(+) A-I      intronic chr5:112343354(+) A-I      intronic chr5:112322058(+) A-I      intronic chr5:112330104(+) A-I      intronic chr5:112316839(+) A-I      intronic chr5:112345663(+) A-I      intronic chr5:112323224(+) A-I      intronic chr5:112323433(+) A-I      intronic chr5:112342677(+) A-I      intronic chr5:112323250(+) A-I      intronic chr5:112348410(+) A-I      intronic chr5:112348480(+) A-I      intronic chr5:112347998(+) A-I      intronic chr5:112324068(+) A-I      intronic chr5:112348380(+) A-I      intronic chr5:112323279(+) A-I      intronic chr5:112323181(+) A-I      intronic chr5:112342646(+) A-I      intronic chr5:112338455(+) A-I      intronic chr5:112338061(+) A-I      intronic chr5:112342747(+) A-I      intronic chr5:112323992(+) A-I      intronic chr5:112322269(+) A-I      intronic chr5:112340665(+) A-I      intronic chr5:112323941(+) A-I      intronic chr5:112322094(+) A-I      intronic chr5:112337864(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCP2	chr5:112342715(+) A-I intron -    22327324 chr5:112340228(+) A-I intron -    21960545 chr5:112322058(+) A-G intron -    22484847 chr5:112322084(+) A-G intron -    22484847 chr5:112322085(+) A-G intron -    22484847 chr5:112322093(+) A-G intron -    22484847 chr5:112322094(+) A-G intron -    22484847 chr5:112322149(+) A-G intron -    22484847 chr5:112323371(+) A-G intron -    22484847 chr5:112323432(+) A-G intron -    22484847 chr5:112323930(+) A-G intron -    22484847 chr5:112323992(+) A-G intron -    22484847 chr5:112324068(+) A-G intron -    22484847 chr5:112324117(+) A-G intron -    22484847 chr5:112335081(+) A-G intron -    22484847 chr5:112335083(+) A-G intron -    22484847 chr5:112335126(+) A-G intron -    22484847 chr5:112335143(+) A-G intron -    22484847 chr5:112335247(+) A-G intron -    22484847 chr5:112335500(+) A-G intron -    22484847 chr5:112335917(+) A-G intron -    22484847 chr5:112335999(+) A-G intron -    22484847 chr5:112336000(+) A-G intron -    22484847 chr5:112337999(+) A-G intron -    22484847 chr5:112338061(+) A-G intron -    22484847 chr5:112338262(+) A-G intron -    22484847 chr5:112338272(+) A-G intron -    22484847 chr5:112338285(+) A-G intron -    22484847 chr5:112338297(+) A-G intron -    22484847 chr5:112340665(+) A-G intron -    22484847 chr5:112342630(+) A-G intron -    22484847 chr5:112342677(+) A-G intron -    22484847 chr5:112342679(+) A-G intron -    22484847 chr5:112342682(+) A-G intron -    22484847 chr5:112342683(+) A-G intron -    22484847 chr5:112342684(+) A-G intron -    22484847 chr5:112342715(+) A-G intron -    22484847 chr5:112342747(+) A-G intron -    22484847 chr5:112343304(+) A-G intron -    22484847 chr5:112343357(+) A-G intron -    22484847 chr5:112347906(+) A-G intron -    22484847 chr5:112347907(+) A-G intron -    22484847 chr5:112347936(+) A-G intron -    22484847 chr5:112348410(+) A-G intron -    22484847 chr5:112352678(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCP2	chr5:112319695-112319696(+) m6A exon//intron       27773535 chr5:112319723-112319724(+) m6A exon//intron       27773535 chr5:112319731-112319732(+) m6A exon//intron       27773535 chr5:112319736-112319737(+) m6A exon//intron       27773535 chr5:112319769-112319770(+) m6A exon//intron       24209618//27773535 chr5:112319829-112319830(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319842-112319843(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319848-112319849(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319860-112319861(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:112319881-112319882(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr5:112319923-112319924(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr5:112320050-112320051(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112320068-112320069(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:112320160-112320161(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr5:112320197-112320198(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:112320208-112320209(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:112320293-112320294(+) m6A exon//intron       - chr5:112320324-112320325(+) m6A exon//intron       - chr5:112343792-112343793(+) m6A exon//intron       22608085 chr5:112343996-112343997(+) m6A exon//intron       22608085 chr5:112346466-112346467(+) m6A CDS       24284625//24981863//22608085 chr5:112346481-112346482(+) m6A CDS       24284625//24981863//22608085 chr5:112346500-112346501(+) m6A CDS       24284625//24981863//22608085 chr5:112349050-112349051(+) m6A CDS       24284625//24981863//22608085 chr5:112349063-112349064(+) m6A CDS       24284625//24981863//22608085 chr5:112349075-112349076(+) m6A CDS       24284625//24981863//22608085 chr5:112349096-112349097(+) m6A CDS       24284625//24981863//22608085 chr5:112349173-112349174(+) m6A CDS       24284625//24981863//22608085 chr5:112349218-112349219(+) m6A 3'UTR       24284625//24981863//22608085 chr5:112349303-112349304(+) m6A 3'UTR       22608085 chr5:112356518-112356519(+) m6A 3'UTR       27773535 chr5:112356592-112356593(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	DCP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: DCP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.