Basic Information:

  VIRBase ID:  

HHID00064746

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-2-3p:  MIMAT0004518          AMOTL1:  NM_130847     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-2-3p	AMOTL1
miRBase Accession/Entrez ID	MIMAT0004518	154810
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	JEAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-2-3p	rs1341798864 chr3:160404818    A/C rs373202341 chr3:160404806    C/T rs768780684 chr3:160404809    T/C rs768780684 chr3:160404809    T/G rs746992239 chr3:160404798    C/CA rs775368833 chr3:160404800    A/G rs775368833 chr3:160404800    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AMOTL1	chr11:94562528(+) A-I      intronic chr11:94544586(+) A-I      intronic chr11:94562482(+) A-I      intronic chr11:94555532(+) A-I      intronic chr11:94544483(+) A-I      intronic chr11:94544473(+) A-I      intronic chr11:94556602(+) A-I      intronic chr11:94540919(+) A-I      intronic chr11:94557532(+) A-I      intronic chr11:94540926(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AMOTL1	chr11:94501541-94501542(+) m6A 5'UTR//intron       24284625 chr11:94501654-94501655(+) m6A 5'UTR//intron       24284625 chr11:94501659-94501660(+) m6A 5'UTR//intron       24284625 chr11:94501704-94501705(+) m6A CDS//intron       24284625 chr11:94528227-94528228(+) m6A CDS//intron       24284625 chr11:94528248-94528249(+) m6A CDS//intron       24284625 chr11:94528277-94528278(+) m6A CDS//intron       24284625//24981863 chr11:94532588-94532589(+) m6A CDS       24284625//24981863//22608085 chr11:94532644-94532645(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94532670-94532671(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94532699-94532700(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94532705-94532706(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532745-94532746(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532762-94532763(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532783-94532784(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532798-94532799(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532832-94532833(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532847-94532848(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532858-94532859(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532877-94532878(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532906-94532907(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94532916-94532917(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94533043-94533044(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94533065-94533066(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94533081-94533082(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94533111-94533112(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:94533269-94533270(+) m6A CDS       24284625//24981863//22575960//22608085 chr11:94533304-94533305(+) m6A CDS       24284625//24981863 chr11:94533334-94533335(+) m6A CDS       24284625//24981863 chr11:94533348-94533349(+) m6A CDS       24284625//24981863 chr11:94533424-94533425(+) m6A CDS       24284625//24981863 chr11:94554756-94554757(+) m6A CDS//exon       24284625 chr11:94554928-94554929(+) m6A CDS//exon       24284625 chr11:94563306-94563307(+) m6A CDS//exon       24981863 chr11:94563307-94563308(+) Cm CDS//exon       - chr11:94563331-94563332(+) m6A CDS       24981863 chr11:94563351-94563352(+) m6A CDS       24981863 chr11:94564628-94564629(+) m6A CDS       24981863 chr11:94564674-94564675(+) m6A CDS       24981863 chr11:94583334-94583335(+) m6A CDS       24284625//24981863 chr11:94583347-94583348(+) m6A CDS       24284625//24981863 chr11:94583357-94583358(+) m6A CDS       24284625//24981863 chr11:94583374-94583375(+) m6A CDS       24284625//24209618//24981863 chr11:94587183-94587184(+) m6A CDS       24284625//24209618 chr11:94587198-94587199(+) m6A CDS       24284625//24209618 chr11:94587205-94587206(+) m6A CDS       24284625//24209618 chr11:94587238-94587239(+) m6A CDS       24284625//24209618 chr11:94592691-94592692(+) m6A CDS       24284625//24209618 chr11:94592748-94592749(+) m6A CDS       24284625//24209618 chr11:94597901-94597902(+) m6A CDS       24284625//24209618//24981863 chr11:94598012-94598013(+) m6A CDS//exon       24284625//24981863 chr11:94599191-94599192(+) m6A CDS//exon       24284625 chr11:94599251-94599252(+) m6A CDS//exon       24284625 chr11:94599266-94599267(+) m6A CDS//exon       24284625 chr11:94599314-94599315(+) m6A CDS//exon       24284625 chr11:94599355-94599356(+) m6A exon//intron       24284625 chr11:94599375-94599376(+) m6A exon//intron       24284625 chr11:94599380-94599381(+) m6A exon//intron       24284625 chr11:94599403-94599404(+) m6A exon//intron       24284625 chr11:94599715-94599716(+) m6A exon//intron       24284625 chr11:94599901-94599902(+) m6A exon//intron       24284625 chr11:94602481-94602482(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94602494-94602495(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94602508-94602509(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94602603-94602604(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94602622-94602623(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94602633-94602634(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94603856-94603857(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94603989-94603990(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94603999-94604000(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94604028-94604029(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94604067-94604068(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94604084-94604085(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94604094-94604095(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:94604114-94604115(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:94604122-94604123(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:94604134-94604135(+) Am 3'UTR       - chr11:94604203-94604204(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:94604223-94604224(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:94604294-94604295(+) m6A 3'UTR       24284625//24981863//22608085 chr11:94604302-94604303(+) m6A 3'UTR       24284625//24981863//22608085 chr11:94604745-94604746(+) m6A 3'UTR       22608085 chr11:94604785-94604786(+) m6A 3'UTR       22608085 chr11:94604846-94604847(+) m6A 3'UTR       24284625//22608085 chr11:94604864-94604865(+) m6A 3'UTR       24284625//22608085 chr11:94605621-94605622(+) m6A 3'UTR       24284625 chr11:94605644-94605645(+) m6A 3'UTR       24284625//24981863//22608085 chr11:94605709-94605710(+) m6A 3'UTR       24284625//24981863//22608085 chr11:94605795-94605796(+) m6A 3'UTR       24284625 chr11:94607528-94607529(+) Y 3'UTR       25219674//26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-2-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Blood|Chronic lymphocytic leukemia cells|Tongue tissue     - Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	AMOTL1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-2-3p
Interactor2: AMOTL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.