Basic Information:

  VIRBase ID:  

HHID00064491

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:  MIMAT0004515          ZSCAN25:  NM_001350986     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-2-5p	ZSCAN25
miRBase Accession/Entrez ID	MIMAT0004515	221785
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF498

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-2-5p	rs1389711693 chr1:207802500    C/A rs200396959 chr1:207802497    C/T rs971770488 chr1:207802503    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZSCAN25	chr7:99225693(+) A-I      intronic chr7:99220509(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZSCAN25	chr7:99214583-99214584(+) m6A 5'UTR//exon       24981863 chr7:99215781-99215782(+) m6A 5'UTR//intron       24981863 chr7:99217294-99217295(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr7:99217332-99217333(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr7:99217346-99217347(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr7:99217393-99217394(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:99217584-99217585(+) m6A CDS//exon//intron       24284625//24209618 chr7:99217738-99217739(+) m6A exon//intron       24284625 chr7:99218984-99218985(+) m6A exon//intron       - chr7:99219028-99219029(+) m6A CDS//exon//intron       24284625 chr7:99219131-99219132(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618 chr7:99219161-99219162(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618 chr7:99219175-99219176(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618 chr7:99219238-99219239(+) m6A exon//intron       24284625 chr7:99221755-99221756(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:99221777-99221778(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:99221785-99221786(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:99221808-99221809(+) m6A exon//intron       24284625 chr7:99221832-99221833(+) m6A exon//intron       24284625 chr7:99221901-99221902(+) m6A exon//intron       - chr7:99221936-99221937(+) m6A exon//intron       - chr7:99221999-99222000(+) m6A exon//intron       - chr7:99222081-99222082(+) m6A exon//intron       25456834 chr7:99222098-99222099(+) m6A exon//intron       25456834 chr7:99226841-99226842(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834 chr7:99226855-99226856(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834 chr7:99227025-99227026(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863 chr7:99227112-99227113(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr7:99227193-99227194(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr7:99227238-99227239(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22575960//22608085 chr7:99227252-99227253(+) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22575960//22608085 chr7:99227311-99227312(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:99227610-99227611(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:99227839-99227840(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:99227914-99227915(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99227936-99227937(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99227959-99227960(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99227984-99227985(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99228032-99228033(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99228064-99228065(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99228079-99228080(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:99228125-99228126(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:99228223-99228224(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr7:99228459-99228460(+) m6A 3'UTR//exon       24981863 chr7:99228479-99228480(+) m6A 3'UTR//exon       24981863 chr7:99228496-99228497(+) m6A 3'UTR//exon       24981863 chr7:99228528-99228529(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	ZSCAN25	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-2-5p
Interactor2: ZSCAN25

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.