Basic Information:

  VIRBase ID:  

HHID00064441

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:  MIMAT0004515          CAND1:  NM_001329675     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-2-5p	CAND1
miRBase Accession/Entrez ID	MIMAT0004515	55832
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TIP120//TIP120A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-2-5p	rs1389711693 chr1:207802500    C/A rs200396959 chr1:207802497    C/T rs971770488 chr1:207802503    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAND1	chr12:67709140(+) A-I      3'UTR chr12:67672055(+) A-I      intronic chr12:67710764(+) A-I      3'UTR chr12:67711015(+) A-I      3'UTR chr12:67711052(+) A-I      3'UTR chr12:67711928(+) A-I      3'UTR chr12:67712021(+) A-I      3'UTR chr12:67712063(+) A-I      3'UTR chr12:67674819(+) A-I      intronic chr12:67674765(+) A-I      intronic chr12:67672137(+) A-I      intronic chr12:67672038(+) A-I      intronic chr12:67669256(+) A-I      intronic chr12:67669073(+) A-I      intronic chr12:67667504(+) A-I      intronic chr12:67667340(+) A-I      intronic chr12:67667331(+) A-I      intronic chr12:67667278(+) A-I      intronic chr12:67684076(+) A-I      intronic chr12:67684236(+) A-I      intronic chr12:67685809(+) A-I      intronic chr12:67674820(+) A-I      intronic chr12:67685869(+) A-I      intronic chr12:67677371(+) A-I      intronic chr12:67677350(+) A-I      intronic chr12:67677290(+) A-I      intronic chr12:67677108(+) A-I      intronic chr12:67676406(+) A-I      intronic chr12:67684058(+) A-I      intronic chr12:67684057(+) A-I      intronic chr12:67684051(+) A-I      intronic chr12:67684044(+) A-I      intronic chr12:67683391(+) A-I      intronic chr12:67683350(+) A-I      intronic chr12:67683338(+) A-I      intronic chr12:67683303(+) A-I      intronic chr12:67683068(+) A-I      intronic chr12:67682105(+) A-I      intronic chr12:67682039(+) A-I      intronic chr12:67682034(+) A-I      intronic chr12:67674990(+) A-I      intronic chr12:67682005(+) A-I      intronic chr12:67681986(+) A-I      intronic chr12:67677149(+) A-I      intronic chr12:67667439(+) A-I      intronic chr12:67684164(+) A-I      intronic chr12:67682146(+) A-I      intronic chr12:67683047(+) A-I      intronic chr12:67677265(+) A-I      intronic chr12:67685693(+) A-I      intronic chr12:67669052(+) A-I      intronic chr12:67684107(+) A-I      intronic chr12:67683356(+) A-I      intronic chr12:67683284(+) A-I      intronic chr12:67684071(+) A-I      intronic chr12:67667322(+) A-I      intronic chr12:67711892(+) A-I      3'UTR chr12:67711152(+) A-I      3'UTR chr12:67709084(+) A-I      3'UTR chr12:67709176(+) A-I      3'UTR chr12:67709186(+) A-I      3'UTR chr12:67709234(+) A-I      3'UTR chr12:67709083(+) A-I      3'UTR chr12:67711537(+) A-I      3'UTR chr12:67711899(+) A-I      3'UTR chr12:67710665(+) A-I      3'UTR chr12:67710673(+) A-I      3'UTR chr12:67711866(+) A-I      3'UTR chr12:67710708(+) A-I      3'UTR chr12:67711902(+) A-I      3'UTR chr12:67711138(+) A-I      3'UTR chr12:67711463(+) A-I      3'UTR chr12:67711429(+) A-I      3'UTR chr12:67710778(+) A-I      3'UTR chr12:67711903(+) A-I      3'UTR chr12:67710781(+) A-I      3'UTR chr12:67711437(+) A-I      3'UTR chr12:67710939(+) A-I      3'UTR chr12:67710695(+) A-I      3'UTR chr12:67711485(+) A-I      3'UTR chr12:67711151(+) A-I      3'UTR chr12:67711846(+) A-I      3'UTR chr12:67710941(+) A-I      3'UTR chr12:67709082(+) A-I      3'UTR chr12:67710696(+) A-I      3'UTR chr12:67711155(+) A-I      3'UTR chr12:67711424(+) A-I      3'UTR chr12:67708959(+) A-I      3'UTR chr12:67711472(+) A-I      3'UTR chr12:67709068(+) A-I      3'UTR chr12:67709077(+) A-I      3'UTR chr12:67709080(+) A-I      3'UTR chr12:67710674(+) A-I      3'UTR chr12:67711869(+) A-I      3'UTR chr12:67709133(+) A-I      3'UTR chr12:67710937(+) A-I      3'UTR chr12:67683248(+) A-I      intronic chr12:67685997(+) A-I      intronic chr12:67667441(+) A-I      intronic chr12:67684212(+) A-I      intronic chr12:67666706(+) A-I      intronic chr12:67683243(+) A-I      intronic chr12:67669187(+) A-I      intronic chr12:67676362(+) A-I      intronic chr12:67672330(+) A-I      intronic chr12:67681992(+) A-I      intronic chr12:67671972(+) A-I      intronic chr12:67669239(+) A-I      intronic chr12:67685725(+) A-I      intronic chr12:67666622(+) A-I      intronic chr12:67684162(+) A-I      intronic chr12:67683392(+) A-I      intronic chr12:67683187(+) A-I      intronic chr12:67669160(+) A-I      intronic chr12:67676239(+) A-I      intronic chr12:67676419(+) A-I      intronic chr12:67683409(+) A-I      intronic chr12:67684160(+) A-I      intronic chr12:67666705(+) A-I      intronic chr12:67683364(+) A-I      intronic chr12:67677102(+) A-I      intronic chr12:67684115(+) A-I      intronic chr12:67684170(+) A-I      intronic chr12:67667403(+) A-I      intronic chr12:67684113(+) A-I      intronic chr12:67685706(+) A-I      intronic chr12:67682147(+) A-I      intronic chr12:67682035(+) A-I      intronic chr12:67685767(+) A-I      intronic chr12:67669051(+) A-I      intronic chr12:67666546(+) A-I      intronic chr12:67667330(+) A-I      intronic chr12:67677243(+) A-I      intronic chr12:67681991(+) A-I      intronic chr12:67683099(+) A-I      intronic chr12:67672077(+) A-I      intronic chr12:67685771(+) A-I      intronic chr12:67685748(+) A-I      intronic chr12:67676407(+) A-I      intronic chr12:67677216(+) A-I      intronic chr12:67677117(+) A-I      intronic chr12:67684224(+) A-I      intronic chr12:67687276(+) A-I      intronic chr12:67684052(+) A-I      intronic chr12:67684100(+) A-I      intronic chr12:67682007(+) A-I      intronic chr12:67685827(+) A-I      intronic chr12:67666616(+) A-I      intronic chr12:67705250(+) A-I      intronic chr12:67677135(+) A-I      intronic chr12:67684206(+) A-I      intronic chr12:67683296(+) A-I      intronic chr12:67686011(+) A-I      intronic chr12:67669263(+) A-I      intronic chr12:67669213(+) A-I      intronic chr12:67711525(+) A-I      3'UTR chr12:67711483(+) A-I      3'UTR chr12:67712018(+) A-I      3'UTR chr12:67711914(+) A-I      3'UTR chr12:67711404(+) A-I      3'UTR chr12:67711402(+) A-I      3'UTR chr12:67711524(+) A-I      3'UTR chr12:67711867(+) A-I      3'UTR chr12:67711877(+) A-I      3'UTR chr12:67711016(+) A-I      3'UTR chr12:67709087(+) A-I      3'UTR chr12:67711001(+) A-I      3'UTR chr12:67711852(+) A-I      3'UTR chr12:67711077(+) A-I      3'UTR chr12:67711363(+) A-I      3'UTR chr12:67712007(+) A-I      3'UTR chr12:67711057(+) A-I      3'UTR chr12:67711838(+) A-I      3'UTR chr12:67711963(+) A-I      3'UTR chr12:67711389(+) A-I      3'UTR chr12:67711502(+) A-I      3'UTR chr12:67712044(+) A-I      3'UTR chr12:67709152(+) A-I      3'UTR chr12:67710770(+) A-I      3'UTR chr12:67711907(+) A-I      3'UTR chr12:67711278(+) A-I      3'UTR chr12:67711028(+) A-I      3'UTR chr12:67711013(+) A-I      3'UTR chr12:67710949(+) A-I      3'UTR chr12:67708980(+) A-I      3'UTR chr12:67710936(+) A-I      3'UTR chr12:67711985(+) A-I      3'UTR chr12:67711446(+) A-I      3'UTR chr12:67710714(+) A-I      3'UTR chr12:67710747(+) A-I      3'UTR chr12:67711824(+) A-I      3'UTR chr12:67709156(+) A-I      3'UTR chr12:67711183(+) A-I      3'UTR chr12:67711819(+) A-I      3'UTR chr12:67711126(+) A-I      3'UTR chr12:67711857(+) A-I      3'UTR chr12:67710971(+) A-I      3'UTR chr12:67711910(+) A-I      3'UTR chr12:67712045(+) A-I      3'UTR chr12:67711443(+) A-I      3'UTR chr12:67710738(+) A-I      3'UTR chr12:67711090(+) A-I      3'UTR chr12:67711977(+) A-I      3'UTR chr12:67710660(+) A-I      3'UTR chr12:67711343(+) A-I      3'UTR chr12:67711326(+) A-I      3'UTR chr12:67711820(+) A-I      3'UTR chr12:67711959(+) A-I      3'UTR chr12:67711497(+) A-I      3'UTR chr12:67711033(+) A-I      3'UTR chr12:67711137(+) A-I      3'UTR chr12:67711484(+) A-I      3'UTR chr12:67708979(+) A-I      3'UTR chr12:67710942(+) A-I      3'UTR chr12:67711428(+) A-I      3'UTR chr12:67711843(+) A-I      3'UTR chr12:67711367(+) A-I      3'UTR chr12:67711193(+) A-I      3'UTR chr12:67710771(+) A-I      3'UTR chr12:67711844(+) A-I      3'UTR chr12:67711978(+) A-I      3'UTR chr12:67712043(+) A-I      3'UTR chr12:67711936(+) A-I      3'UTR chr12:67710745(+) A-I      3'UTR chr12:67711380(+) A-I      3'UTR chr12:67709137(+) A-I      3'UTR chr12:67709081(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAND1	chr12:67683187(+) A-I intron -    21960545 chr12:67683296(+) A-I intron -    21960545 chr12:67684160(+) A-I intron -    21960545 chr12:67684162(+) A-I intron -    21960545 chr12:67666546(+) A-G intron -    22484847 chr12:67667322(+) A-G intron -    22484847 chr12:67667330(+) A-G intron -    22484847 chr12:67667439(+) A-G intron -    22484847 chr12:67667441(+) A-G intron -    22484847 chr12:67669239(+) A-G intron -    22484847 chr12:67671972(+) A-G intron -    22484847 chr12:67672077(+) A-G intron -    22484847 chr12:67676239(+) A-G intron -    22484847 chr12:67676362(+) A-G intron -    22484847 chr12:67676407(+) A-G intron -    22484847 chr12:67676419(+) A-G intron -    22484847 chr12:67677102(+) A-G intron -    22484847 chr12:67677117(+) A-G intron -    22484847 chr12:67677135(+) A-G intron -    22484847 chr12:67677149(+) A-G intron -    22484847 chr12:67677216(+) A-G intron -    22484847 chr12:67681991(+) A-G intron -    22484847 chr12:67681992(+) A-G intron -    22484847 chr12:67682007(+) A-G intron -    22484847 chr12:67682035(+) A-G intron -    22484847 chr12:67682146(+) A-G intron -    22484847 chr12:67682147(+) A-G intron -    22484847 chr12:67683243(+) A-G intron -    22484847 chr12:67683248(+) A-G intron -    22484847 chr12:67683284(+) A-G intron -    22484847 chr12:67683296(+) A-G intron -    22484847 chr12:67683356(+) A-G intron -    22484847 chr12:67683364(+) A-G intron -    22484847 chr12:67683411(+) T-C intron -    22484847 chr12:67683418(+) G-A intron -    22484847 chr12:67684052(+) A-G intron -    22484847 chr12:67684071(+) A-G intron -    22484847 chr12:67684100(+) A-G intron -    22484847 chr12:67684107(+) A-G intron -    22484847 chr12:67684113(+) A-G intron -    22484847 chr12:67684115(+) A-G intron -    22484847 chr12:67684162(+) A-G intron -    22484847 chr12:67684164(+) A-G intron -    22484847 chr12:67684170(+) A-G intron -    22484847 chr12:67684206(+) A-G intron -    22484847 chr12:67685725(+) A-G intron -    22484847 chr12:67685748(+) A-G intron -    22484847 chr12:67685771(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAND1	chr12:67663558-67663559(+) m6A CDS//exon       24284625//24209618//24981863 chr12:67675719-67675720(+) m6A CDS//exon       26404942 chr12:67696221-67696222(+) m6A CDS       24981863//22575960 chr12:67699036-67699037(+) m6A CDS//intron       24284625//22575960 chr12:67699229-67699230(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67699252-67699253(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67699301-67699302(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67699432-67699433(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67699448-67699449(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:67699486-67699487(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:67699658-67699659(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67699667-67699668(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67699717-67699718(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67699746-67699747(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67699889-67699890(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr12:67699927-67699928(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr12:67700006-67700007(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67700015-67700016(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr12:67706599-67706600(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67706629-67706630(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67706679-67706680(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:67706739-67706740(+) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085 chr12:67706822-67706823(+) m6A 3'UTR       27773535 chr12:67706864-67706865(+) m6A 3'UTR       27773535 chr12:67710752-67710753(+) m6A 3'UTR       24981863 chr12:67710879-67710880(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	CAND1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-2-5p
Interactor2: CAND1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.