Basic Information:

  VIRBase ID:  

HHID00064377

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:  MIMAT0004515          SLC7A6:  NM_003983     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-2-5p	SLC7A6
miRBase Accession/Entrez ID	MIMAT0004515	9057
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LAT-2//LAT3//y+LAT-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-2-5p	rs1389711693 chr1:207802500    C/A rs200396959 chr1:207802497    C/T rs971770488 chr1:207802503    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC7A6	chr16:68330078(+) A-I      intronic chr16:68299676(+) A-I      intronic chr16:68313535(+) A-I      intronic chr16:68313506(+) A-I      intronic chr16:68321164(+) A-I      intronic chr16:68321133(+) A-I      intronic chr16:68320915(+) A-I      intronic chr16:68316795(+) A-I      intronic chr16:68316782(+) A-I      intronic chr16:68316601(+) A-I      intronic chr16:68316262(+) A-I      intronic chr16:68316208(+) A-I      intronic chr16:68313608(+) A-I      intronic chr16:68313590(+) A-I      intronic chr16:68313583(+) A-I      intronic chr16:68313581(+) A-I      intronic chr16:68313571(+) A-I      intronic chr16:68313497(+) A-I      intronic chr16:68313453(+) A-I      intronic chr16:68313227(+) A-I      intronic chr16:68313194(+) A-I      intronic chr16:68313178(+) A-I      intronic chr16:68313141(+) A-I      intronic chr16:68313124(+) A-I      intronic chr16:68313019(+) A-I      intronic chr16:68311631(+) A-I      intronic chr16:68311175(+) A-I      intronic chr16:68311164(+) A-I      intronic chr16:68311091(+) A-I      intronic chr16:68311090(+) A-I      intronic chr16:68310863(+) A-I      intronic chr16:68310802(+) A-I      intronic chr16:68310651(+) A-I      intronic chr16:68309404(+) A-I      intronic chr16:68309312(+) A-I      intronic chr16:68309252(+) A-I      intronic chr16:68306121(+) A-I      intronic chr16:68306115(+) A-I      intronic chr16:68305958(+) A-I      intronic chr16:68305893(+) A-I      intronic chr16:68305846(+) A-I      intronic chr16:68305834(+) A-I      intronic chr16:68305798(+) A-I      intronic chr16:68305727(+) A-I      intronic chr16:68299935(+) A-I      intronic chr16:68318781(+) A-I      intronic chr16:68320925(+) A-I      intronic chr16:68313200(+) A-I      intronic chr16:68303536(+) A-I      intronic chr16:68305343(+) A-I      intronic chr16:68313080(+) A-I      intronic chr16:68305308(+) A-I      intronic chr16:68313653(+) A-I      intronic chr16:68310783(+) A-I      intronic chr16:68303887(+) A-I      intronic chr16:68322746(+) A-I      intronic chr16:68313170(+) A-I      intronic chr16:68309313(+) A-I      intronic chr16:68321020(+) A-I      intronic chr16:68316290(+) A-I      intronic chr16:68316225(+) A-I      intronic chr16:68319813(+) A-I      intronic chr16:68313230(+) A-I      intronic chr16:68300042(+) A-I      intronic chr16:68319766(+) A-I      intronic chr16:68303523(+) A-I      intronic chr16:68309342(+) A-I      intronic chr16:68316725(+) A-I      intronic chr16:68321155(+) A-I      intronic chr16:68313467(+) A-I      intronic chr16:68313130(+) A-I      intronic chr16:68311070(+) A-I      intronic chr16:68313614(+) A-I      intronic chr16:68305326(+) A-I      intronic chr16:68305928(+) A-I      intronic chr16:68309377(+) A-I      intronic chr16:68313465(+) A-I      intronic chr16:68305164(+) A-I      intronic chr16:68310741(+) A-I      intronic chr16:68306284(+) A-I      intronic chr16:68316239(+) A-I      intronic chr16:68309309(+) A-I      intronic chr16:68311129(+) A-I      intronic chr16:68312989(+) A-I      intronic chr16:68311587(+) A-I      intronic chr16:68311015(+) A-I      intronic chr16:68306277(+) A-I      intronic chr16:68310672(+) A-I      intronic chr16:68311013(+) A-I      intronic chr16:68310645(+) A-I      intronic chr16:68314843(+) A-I      intronic chr16:68310850(+) A-I      intronic chr16:68319806(+) A-I      intronic chr16:68321157(+) A-I      intronic chr16:68310623(+) A-I      intronic chr16:68310853(+) A-I      intronic chr16:68316723(+) A-I      intronic chr16:68316540(+) A-I      intronic chr16:68316737(+) A-I      intronic chr16:68313090(+) A-I      intronic chr16:68320974(+) A-I      intronic chr16:68303582(+) A-I      intronic chr16:68316293(+) A-I      intronic chr16:68313689(+) A-I      intronic chr16:68313461(+) A-I      intronic chr16:68303895(+) A-I      intronic chr16:68316243(+) A-I      intronic chr16:68305847(+) A-I      intronic chr16:68305779(+) A-I      intronic chr16:68306343(+) A-I      intronic chr16:68310847(+) A-I      intronic chr16:68303923(+) A-I      intronic chr16:68327057(+) A-I      intronic chr16:68310717(+) A-I      intronic chr16:68312984(+) A-I      intronic chr16:68311803(+) A-I      intronic chr16:68320966(+) A-I      intronic chr16:68309244(+) A-I      intronic chr16:68319785(+) A-I      intronic chr16:68303596(+) A-I      intronic chr16:68311046(+) A-I      intronic chr16:68316238(+) A-I      intronic chr16:68310743(+) A-I      intronic chr16:68311177(+) A-I      intronic chr16:68309334(+) A-I      intronic chr16:68326448(+) A-I      intronic chr16:68312040(+) A-I      intronic chr16:68306257(+) A-I      intronic chr16:68320980(+) A-I      intronic chr16:68303607(+) A-I      intronic chr16:68305785(+) A-I      intronic chr16:68310706(+) A-I      intronic chr16:68306315(+) A-I      intronic chr16:68311069(+) A-I      intronic chr16:68319983(+) A-I      intronic chr16:68319982(+) A-I      intronic chr16:68312967(+) A-I      intronic chr16:68306218(+) A-I      intronic chr16:68313134(+) A-I      intronic chr16:68322685(+) A-I      intronic chr16:68305170(+) A-I      intronic chr16:68310740(+) A-I      intronic chr16:68319742(+) A-I      intronic chr16:68310827(+) A-I      intronic chr16:68311997(+) A-I      intronic chr16:68316682(+) A-I      intronic chr16:68306292(+) A-I      intronic chr16:68306055(+) A-I      intronic chr16:68320955(+) A-I      intronic chr16:68319720(+) A-I      intronic chr16:68313568(+) A-I      intronic chr16:68316286(+) A-I      intronic chr16:68310759(+) A-I      intronic chr16:68311896(+) A-I      intronic chr16:68311170(+) A-I      intronic chr16:68309315(+) A-I      intronic chr16:68303578(+) A-I      intronic chr16:68310791(+) A-I      intronic chr16:68319909(+) A-I      intronic chr16:68321081(+) A-I      intronic chr16:68316660(+) A-I      intronic chr16:68310646(+) A-I      intronic chr16:68319726(+) A-I      intronic chr16:68321010(+) A-I      intronic chr16:68313029(+) A-I      intronic chr16:68322614(+) A-I      intronic chr16:68305822(+) A-I      intronic chr16:68311476(+) A-I      intronic chr16:68303514(+) A-I      intronic chr16:68312983(+) A-I      intronic chr16:68309423(+) A-I      intronic chr16:68319919(+) A-I      intronic chr16:68313639(+) A-I      intronic chr16:68305784(+) A-I      intronic chr16:68323179(+) A-I      intronic chr16:68313000(+) A-I      intronic chr16:68321143(+) A-I      intronic chr16:68306062(+) A-I      intronic chr16:68306194(+) A-I      intronic chr16:68319853(+) A-I      intronic chr16:68313567(+) A-I      intronic chr16:68311488(+) A-I      intronic chr16:68309243(+) A-I      intronic chr16:68311043(+) A-I      intronic chr16:68305729(+) A-I      intronic chr16:68313644(+) A-I      intronic chr16:68319889(+) A-I      intronic chr16:68303810(+) A-I      intronic chr16:68311131(+) A-I      intronic chr16:68310742(+) A-I      intronic chr16:68312120(+) A-I      intronic chr16:68313210(+) A-I      intronic chr16:68319892(+) A-I      intronic chr16:68310736(+) A-I      intronic chr16:68311009(+) A-I      intronic chr16:68305980(+) A-I      intronic chr16:68316216(+) A-I      intronic chr16:68320998(+) A-I      intronic chr16:68321022(+) A-I      intronic chr16:68311123(+) A-I      intronic chr16:68327272(+) A-I      intronic chr16:68312132(+) A-I      intronic chr16:68313622(+) A-I      intronic chr16:68313147(+) A-I      intronic chr16:68313006(+) A-I      intronic chr16:68311107(+) A-I      intronic chr16:68327064(+) A-I      intronic chr16:68306229(+) A-I      intronic chr16:68313677(+) A-I      intronic chr16:68311579(+) A-I      intronic chr16:68306203(+) A-I      intronic chr16:68311116(+) A-I      intronic chr16:68313702(+) A-I      intronic chr16:68313125(+) A-I      intronic chr16:68309378(+) A-I      intronic chr16:68313559(+) A-I      intronic chr16:68311119(+) A-I      intronic chr16:68320913(+) A-I      intronic chr16:68303729(+) A-I      intronic chr16:68316217(+) A-I      intronic chr16:68318842(+) A-I      intronic chr16:68310751(+) A-I      intronic chr16:68311959(+) A-I      intronic chr16:68305338(+) A-I      intronic chr16:68311051(+) A-I      intronic chr16:68313542(+) A-I      intronic chr16:68311960(+) A-I      intronic chr16:68311173(+) A-I      intronic chr16:68311611(+) A-I      intronic chr16:68317949(+) A-I      intronic chr16:68316194(+) A-I      intronic chr16:68309450(+) A-I      intronic chr16:68306361(+) A-I      intronic chr16:68317978(+) A-I      intronic chr16:68313220(+) A-I      intronic chr16:68320981(+) A-I      intronic chr16:68313625(+) A-I      intronic chr16:68309241(+) A-I      intronic chr16:68318788(+) A-I      intronic chr16:68321070(+) A-I      intronic chr16:68316783(+) A-I      intronic chr16:68306179(+) A-I      intronic chr16:68311200(+) A-I      intronic chr16:68311059(+) A-I      intronic chr16:68305769(+) A-I      intronic chr16:68307804(+) A-I      5'UTR chr16:68307767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC7A6	chr16:68310783(+) A-I intron -    22327324 chr16:68319853(+) A-I intron -    22327324 chr16:68317978(+) A-G intron -    22484847 chr16:68318078(+) T-C intron -    22484847 chr16:68300923(+) T-C intron -    22484847 chr16:68306203(+) A-G intron -    22484847 chr16:68306257(+) A-G intron -    22484847 chr16:68306277(+) A-G intron -    22484847 chr16:68307767(+) A-G exon 5'UTR    22484847 chr16:68309376(+) T-C intron -    22484847 chr16:68310751(+) A-G intron -    22484847 chr16:68310783(+) A-G intron -    22484847 chr16:68310850(+) A-G intron -    22484847 chr16:68311051(+) A-G intron -    22484847 chr16:68311070(+) A-G intron -    22484847 chr16:68316238(+) A-G intron -    22484847 chr16:68316243(+) A-G intron -    22484847 chr16:68318762(+) C-T intron -    22484847 chr16:68319747(+) T-C intron -    22484847 chr16:68319853(+) A-G intron -    22484847 chr16:68320925(+) A-G intron -    22484847 chr16:68320974(+) A-G intron -    22484847 chr16:68321143(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC7A6	chr16:68308603-68308604(+) m6A 5'UTR       24284625 chr16:68308619-68308620(+) m6A 5'UTR       24284625 chr16:68308740-68308741(+) m6A CDS       24284625 chr16:68308935-68308936(+) m6A CDS//intron       24284625//22608085 chr16:68330648-68330649(+) Y 3'UTR//CDS//exon       26075521 chr16:68331222-68331223(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr16:68331293-68331294(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68331393-68331394(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:68331939-68331940(+) m6A 3'UTR//intron       24981863//22608085 chr16:68332034-68332035(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332042-68332043(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332087-68332088(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332109-68332110(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332160-68332161(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332177-68332178(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332233-68332234(+) m6A 3'UTR//intron       24284625//22608085 chr16:68332293-68332294(+) m6A 3'UTR//intron       24284625 chr16:68332305-68332306(+) m6A 3'UTR//intron       24284625 chr16:68332352-68332353(+) m6A 3'UTR//intron       24284625//24209618 chr16:68332435-68332436(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332517-68332518(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332550-68332551(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68332733-68332734(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr16:68332758-68332759(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr16:68333344-68333345(+) m6A 3'UTR       27773535 chr16:68333795-68333796(+) m6A 3'UTR       27773535 chr16:68333844-68333845(+) m6A 3'UTR       24981863//27773535 chr16:68334362-68334363(+) m6A 3'UTR       27773535 chr16:68334448-68334449(+) m6A 3'UTR       27773535 chr16:68334545-68334546(+) m6A 3'UTR       27773535 chr16:68334912-68334913(+) m6A 3'UTR       24284625 chr16:68334946-68334947(+) m6A 3'UTR       24284625//22575960 chr16:68334999-68335000(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr16:68335090-68335091(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335125-68335126(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335154-68335155(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335163-68335164(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335173-68335174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335215-68335216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335647-68335648(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	SLC7A6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-2-5p
Interactor2: SLC7A6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.