Basic Information:

  VIRBase ID:  

HHID00064351

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:  MIMAT0004515          REST:  NM_001193508     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-2-5p	REST
miRBase Accession/Entrez ID	MIMAT0004515	5978
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DFNA27//GINGF5//HGF5//NRSF//WT6//XBR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-2-5p	rs1389711693 chr1:207802500    C/A rs200396959 chr1:207802497    C/T rs971770488 chr1:207802503    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	REST	chr4:57788646(+) A-I      intronic chr4:57788641(+) A-I      intronic chr4:57788637(+) A-I      intronic chr4:57788606(+) A-I      intronic chr4:57788605(+) A-I      intronic chr4:57788598(+) A-I      intronic chr4:57788580(+) A-I      intronic chr4:57788573(+) A-I      intronic chr4:57787737(+) A-I      intronic chr4:57787715(+) A-I      intronic chr4:57787229(+) A-I      intronic chr4:57787159(+) A-I      intronic chr4:57787101(+) A-I      intronic chr4:57786807(+) A-I      intronic chr4:57786778(+) A-I      intronic chr4:57786770(+) A-I      intronic chr4:57786743(+) A-I      intronic chr4:57786664(+) A-I      intronic chr4:57785051(+) A-I      intronic chr4:57785046(+) A-I      intronic chr4:57784976(+) A-I      intronic chr4:57784963(+) A-I      intronic chr4:57784949(+) A-I      intronic chr4:57784778(+) A-I      intronic chr4:57784040(+) A-I      intronic chr4:57784038(+) A-I      intronic chr4:57783954(+) A-I      intronic chr4:57783633(+) A-I      intronic chr4:57782208(+) A-I      intronic chr4:57781688(+) A-I      intronic chr4:57781625(+) A-I      intronic chr4:57781613(+) A-I      intronic chr4:57781516(+) A-I      intronic chr4:57781468(+) A-I      intronic chr4:57780354(+) A-I      intronic chr4:57780016(+) A-I      intronic chr4:57779932(+) A-I      intronic chr4:57779892(+) A-I      intronic chr4:57803954(+) A-I      intronic chr4:57803200(+) A-I      intronic chr4:57803191(+) A-I      intronic chr4:57802368(+) A-I      intronic chr4:57802334(+) A-I      intronic chr4:57802262(+) A-I      intronic chr4:57793212(+) A-I      intronic chr4:57805807(+) A-I      intronic chr4:57805792(+) A-I      intronic chr4:57786824(+) A-I      intronic chr4:57793203(+) A-I      intronic chr4:57786813(+) A-I      intronic chr4:57792427(+) A-I      intronic chr4:57792401(+) A-I      intronic chr4:57792375(+) A-I      intronic chr4:57790094(+) A-I      intronic chr4:57790089(+) A-I      intronic chr4:57790069(+) A-I      intronic chr4:57790053(+) A-I      intronic chr4:57789974(+) A-I      intronic chr4:57802826(+) A-I      intronic chr4:57792287(+) A-I      intronic chr4:57789746(+) A-I      intronic chr4:57787132(+) A-I      intronic chr4:57812870(+) A-I      intronic chr4:57812847(+) A-I      intronic chr4:57789696(+) A-I      intronic chr4:57808436(+) A-I      intronic chr4:57813501(+) A-I      intronic chr4:57812835(+) A-I      intronic chr4:57812818(+) A-I      intronic chr4:57811895(+) A-I      intronic chr4:57811787(+) A-I      intronic chr4:57810567(+) A-I      intronic chr4:57810566(+) A-I      intronic chr4:57810547(+) A-I      intronic chr4:57809264(+) A-I      intronic chr4:57808849(+) A-I      intronic chr4:57808445(+) A-I      intronic chr4:57808418(+) A-I      intronic chr4:57808374(+) A-I      intronic chr4:57805519(+) A-I      intronic chr4:57805502(+) A-I      intronic chr4:57805492(+) A-I      intronic chr4:57805474(+) A-I      intronic chr4:57805456(+) A-I      intronic chr4:57787811(+) A-I      intronic chr4:57803190(+) A-I      intronic chr4:57791178(+) A-I      intronic chr4:57786808(+) A-I      intronic chr4:57793079(+) A-I      intronic chr4:57790897(+) A-I      intronic chr4:57789710(+) A-I      intronic chr4:57802915(+) A-I      intronic chr4:57784614(+) A-I      intronic chr4:57806710(+) A-I      intronic chr4:57805738(+) A-I      intronic chr4:57784978(+) A-I      intronic chr4:57789567(+) A-I      intronic chr4:57784065(+) A-I      intronic chr4:57784001(+) A-I      intronic chr4:57780355(+) A-I      intronic chr4:57787171(+) A-I      intronic chr4:57803847(+) A-I      intronic chr4:57792412(+) A-I      intronic chr4:57787756(+) A-I      intronic chr4:57784054(+) A-I      intronic chr4:57786767(+) A-I      intronic chr4:57787241(+) A-I      intronic chr4:57781675(+) A-I      intronic chr4:57786821(+) A-I      intronic chr4:57803260(+) A-I      intronic chr4:57789663(+) A-I      intronic chr4:57808992(+) A-I      intronic chr4:57805425(+) A-I      intronic chr4:57805805(+) A-I      intronic chr4:57789484(+) A-I      intronic chr4:57805348(+) A-I      intronic chr4:57786785(+) A-I      intronic chr4:57813497(+) A-I      intronic chr4:57803819(+) A-I      intronic chr4:57805697(+) A-I      intronic chr4:57791124(+) A-I      intronic chr4:57784033(+) A-I      intronic chr4:57786764(+) A-I      intronic chr4:57791480(+) A-I      intronic chr4:57791125(+) A-I      intronic chr4:57786768(+) A-I      intronic chr4:57791654(+) A-I      intronic chr4:57786681(+) A-I      intronic chr4:57806720(+) A-I      intronic chr4:57803240(+) A-I      intronic chr4:57803298(+) A-I      intronic chr4:57806763(+) A-I      intronic chr4:57784962(+) A-I      intronic chr4:57805428(+) A-I      intronic chr4:57782131(+) A-I      intronic chr4:57812857(+) A-I      intronic chr4:57787125(+) A-I      intronic chr4:57784553(+) A-I      intronic chr4:57810823(+) A-I      intronic chr4:57786713(+) A-I      intronic chr4:57811743(+) A-I      intronic chr4:57808340(+) A-I      intronic chr4:57810824(+) A-I      intronic chr4:57791210(+) A-I      intronic chr4:57805795(+) A-I      intronic chr4:57779324(+) A-I      intronic chr4:57804511(+) A-I      intronic chr4:57806190(+) A-I      intronic chr4:57808993(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	REST	chr4:57778686(+) A-T intron -    22484847 chr4:57779874(+) A-G intron -    22484847 chr4:57780004(+) T-C intron -    22484847 chr4:57780072(+) A-G intron -    22484847 chr4:57780355(+) A-G intron -    22484847 chr4:57782131(+) A-G intron -    22484847 chr4:57784001(+) A-G intron -    22484847 chr4:57784033(+) A-G intron -    22484847 chr4:57784064(+) A-G intron -    22484847 chr4:57784553(+) A-G intron -    22484847 chr4:57784780(+) A-G intron -    22484847 chr4:57784962(+) A-G intron -    22484847 chr4:57784978(+) A-G intron -    22484847 chr4:57784982(+) A-G intron -    22484847 chr4:57786767(+) A-G intron -    22484847 chr4:57786768(+) A-G intron -    22484847 chr4:57786785(+) A-G intron -    22484847 chr4:57786808(+) A-G intron -    22484847 chr4:57786821(+) A-G intron -    22484847 chr4:57786835(+) A-G intron -    22484847 chr4:57787125(+) A-G intron -    22484847 chr4:57787171(+) A-G intron -    22484847 chr4:57789567(+) A-G intron -    22484847 chr4:57789658(+) A-G intron -    22484847 chr4:57789663(+) A-G intron -    22484847 chr4:57791094(+) A-G intron -    22484847 chr4:57791095(+) A-G intron -    22484847 chr4:57791195(+) A-G intron -    22484847 chr4:57792295(+) A-G intron -    22484847 chr4:57792429(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	REST	chr4:57774301-57774302(+) m6A 5'UTR       - chr4:57776923-57776924(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr4:57777016-57777017(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777028-57777029(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777079-57777080(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777109-57777110(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777118-57777119(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777126-57777127(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777133-57777134(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777148-57777149(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777163-57777164(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777233-57777234(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777249-57777250(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57777269-57777270(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr4:57777274-57777275(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr4:57777319-57777320(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr4:57777511-57777512(+) m6A CDS//exon       24981863//22608085 chr4:57777598-57777599(+) m6A CDS//exon       24981863//22608085 chr4:57777609-57777610(+) m6A CDS//exon       24981863//22608085 chr4:57777660-57777661(+) m6A CDS//exon       22608085 chr4:57777669-57777670(+) m6A CDS//exon       22608085 chr4:57777692-57777693(+) m6A CDS//exon       22608085 chr4:57785974-57785975(+) m6A CDS//exon       22608085 chr4:57786002-57786003(+) m6A CDS//exon       22608085 chr4:57786016-57786017(+) m6A CDS//exon       24284625//22608085 chr4:57796079-57796080(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr4:57796100-57796101(+) m6A CDS//exon//intron       24284625//24981863//22608085 chr4:57796131-57796132(+) m6A CDS//intron       24284625//24981863//22608085 chr4:57796157-57796158(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr4:57796177-57796178(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr4:57796278-57796279(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796301-57796302(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796311-57796312(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796359-57796360(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796370-57796371(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796497-57796498(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr4:57796524-57796525(+) Gm CDS//intron       - chr4:57796569-57796570(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr4:57796770-57796771(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr4:57796820-57796821(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr4:57796849-57796850(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr4:57797100-57797101(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr4:57797144-57797145(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:57797300-57797301(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr4:57797659-57797660(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr4:57797792-57797793(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:57797797-57797798(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:57797820-57797821(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:57797834-57797835(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:57797841-57797842(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:57797872-57797873(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:57797884-57797885(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:57797927-57797928(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57797985-57797986(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:57798254-57798255(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr4:57798322-57798323(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:57798329-57798330(+) m6A 3'UTR       24981863//22608085 chr4:57798390-57798391(+) m6A 3'UTR       24981863//22608085 chr4:57800163-57800164(+) m6A 3'UTR       24981863//27773535 chr4:57800220-57800221(+) m6A 3'UTR       24981863//27773535 chr4:57800577-57800578(+) m6A 3'UTR       22608085 chr4:57800592-57800593(+) m6A 3'UTR       22608085 chr4:57800598-57800599(+) m6A 3'UTR       22608085 chr4:57800615-57800616(+) m6A 3'UTR       22608085 chr4:57800644-57800645(+) m6A 3'UTR       24981863//22608085 chr4:57800668-57800669(+) m6A 3'UTR       24981863//22608085 chr4:57800696-57800697(+) m6A 3'UTR       24981863//22608085 chr4:57800727-57800728(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	REST	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-2-5p
Interactor2: REST

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.