Detail Information

Basic Information:


  VIRBase ID:  

HHID00064108

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           TMEM167A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p TMEM167A
miRBase
Accession/Entrez ID		 MIMAT0004513 153339
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TMEM167

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM167A
chr5:82370728(-) A-I      intronic
chr5:82370767(-) A-I      intronic
chr5:82357352(-) A-I      intronic
chr5:82357366(-) A-I      intronic
chr5:82368486(-) A-I      intronic
chr5:82371512(-) A-I      intronic
chr5:82368423(-) A-I      intronic
chr5:82368539(-) A-I      intronic
chr5:82370727(-) A-I      intronic
chr5:82371371(-) A-I      intronic
chr5:82371481(-) A-I      intronic
chr5:82371398(-) A-I      intronic
chr5:82371391(-) A-I      intronic
chr5:82357418(-) A-I      intronic
chr5:82370796(-) A-I      intronic
chr5:82368530(-) A-I      intronic
chr5:82357487(-) A-I      intronic
chr5:82357415(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM167A
chr5:82357418(-) A-G intron -    22484847
chr5:82370861(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM167A
chr5:82349080-82349081(-) m6A 3'UTR       24284625//25456834//22608085
chr5:82349209-82349210(-) m6A 3'UTR       22608085
chr5:82352749-82352750(-) m6A 3'UTR//exon       24981863//22608085
chr5:82352801-82352802(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82352850-82352851(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82352856-82352857(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82360830-82360831(-) m6A CDS//exon//intron       24284625
chr5:82360841-82360842(-) m6A CDS//exon//intron       24284625
chr5:82367200-82367201(-) m6A exon//intron       24284625//24981863
chr5:82373205-82373206(-) m6A 5'UTR//exon//intron       25456834//24981863
chr5:82373649-82373650(-) m6A exon       25456834
chr5:82373665-82373666(-) m6A exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TMEM167A
Chromatin K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: TMEM167A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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