Detail Information

Basic Information:


  VIRBase ID:  

HHID00063967

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-99a-3p:           PPP2CA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-99a-3p PPP2CA
miRBase
Accession/Entrez ID		 MIMAT0004511 5515
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NEDLBA//PP2Ac//PP2CA//PP2Calpha//RP-C

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-99a-3p
rs1214222916 chr21:16539147    T/C
rs1419616925 chr21:16539158    T/A
rs763134262 chr21:16539151    A/G
rs766428664 chr21:16539153    G/A
rs774748688 chr21:16539159    G/C
rs950382507 chr21:16539154    G/A
rs1271070422 chr21:16539142    C/T
rs913397001 chr21:16539145    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PPP2CA
chr5:133547788(-) A-I      intronic
chr5:133552728(-) A-I      intronic
chr5:133552871(-) A-I      intronic
chr5:133552902(-) A-I      intronic
chr5:133554538(-) A-I      intronic
chr5:133542224(-) A-I      intronic
chr5:133534000(-) A-I      intronic
chr5:133534037(-) A-I      intronic
chr5:133534062(-) A-I      intronic
chr5:133534395(-) A-I      intronic
chr5:133534615(-) A-I      intronic
chr5:133534435(-) A-I      intronic
chr5:133534394(-) A-I      intronic
chr5:133557478(-) A-I      intronic
chr5:133557061(-) A-I      intronic
chr5:133556855(-) A-I      intronic
chr5:133556074(-) A-I      intronic
chr5:133556067(-) A-I      intronic
chr5:133542883(-) A-I      intronic
chr5:133556041(-) A-I      intronic
chr5:133555987(-) A-I      intronic
chr5:133543323(-) A-I      intronic
chr5:133543010(-) A-I      intronic
chr5:133557583(-) A-I      intronic
chr5:133557464(-) A-I      intronic
chr5:133547643(-) A-I      intronic
chr5:133543341(-) A-I      intronic
chr5:133546884(-) A-I      intronic
chr5:133546914(-) A-I      intronic
chr5:133546920(-) A-I      intronic
chr5:133547239(-) A-I      intronic
chr5:133547260(-) A-I      intronic
chr5:133547279(-) A-I      intronic
chr5:133547418(-) A-I      intronic
chr5:133547534(-) A-I      intronic
chr5:133547629(-) A-I      intronic
chr5:133547711(-) A-I      intronic
chr5:133554544(-) A-I      intronic
chr5:133555982(-) A-I      intronic
chr5:133534618(-) A-I      intronic
chr5:133543520(-) A-I      intronic
chr5:133547716(-) A-I      intronic
chr5:133550904(-) A-I      intronic
chr5:133547329(-) A-I      intronic
chr5:133547558(-) A-I      intronic
chr5:133557547(-) A-I      intronic
chr5:133555924(-) A-I      intronic
chr5:133552467(-) A-I      intronic
chr5:133556900(-) A-I      intronic
chr5:133547350(-) A-I      intronic
chr5:133555884(-) A-I      intronic
chr5:133557596(-) A-I      intronic
chr5:133557050(-) A-I      intronic
chr5:133555993(-) A-I      intronic
chr5:133543013(-) A-I      intronic
chr5:133549768(-) A-I      intronic
chr5:133555620(-) A-I      intronic
chr5:133550899(-) A-I      intronic
chr5:133557096(-) A-I      intronic
chr5:133552968(-) A-I      intronic
chr5:133555671(-) A-I      intronic
chr5:133557626(-) A-I      intronic
chr5:133549570(-) A-I      intronic
chr5:133547434(-) A-I      intronic
chr5:133555899(-) A-I      intronic
chr5:133551368(-) A-I      intronic
chr5:133555978(-) A-I      intronic
chr5:133551183(-) A-I      intronic
chr5:133543441(-) A-I      intronic
chr5:133556973(-) A-I      intronic
chr5:133549438(-) A-I      intronic
chr5:133543356(-) A-I      intronic
chr5:133557008(-) A-I      intronic
chr5:133554436(-) A-I      intronic
chr5:133534295(-) A-I      intronic
chr5:133555946(-) A-I      intronic
chr5:133556972(-) A-I      intronic
chr5:133543433(-) A-I      intronic
chr5:133556899(-) A-I      intronic
chr5:133547552(-) A-I      intronic
chr5:133552437(-) A-I      intronic
chr5:133551338(-) A-I      intronic
chr5:133552716(-) A-I      intronic
chr5:133547641(-) A-I      intronic
chr5:133543014(-) A-I      intronic
chr5:133549602(-) A-I      intronic
chr5:133550864(-) A-I      intronic
chr5:133543473(-) A-I      intronic
chr5:133547646(-) A-I      intronic
chr5:133556974(-) A-I      intronic
chr5:133556068(-) A-I      intronic
chr5:133547335(-) A-I      intronic
chr5:133551329(-) A-I      intronic
chr5:133556142(-) A-I      intronic
chr5:133557633(-) A-I      intronic
chr5:133556850(-) A-I      intronic
chr5:133551405(-) A-I      intronic
chr5:133546879(-) A-I      intronic
chr5:133552470(-) A-I      intronic
chr5:133546278(-) A-I      intronic
chr5:133551425(-) A-I      intronic
chr5:133554445(-) A-I      intronic
chr5:133557024(-) A-I      intronic
chr5:133552474(-) A-I      intronic
chr5:133543360(-) A-I      intronic
chr5:133556977(-) A-I      intronic
chr5:133557645(-) A-I      intronic
chr5:133557590(-) A-I      intronic
chr5:133556073(-) A-I      intronic
chr5:133542358(-) A-I      intronic
chr5:133555967(-) A-I      intronic
chr5:133543019(-) A-I      intronic
chr5:133552895(-) A-I      intronic
chr5:133556134(-) A-I      intronic
chr5:133534612(-) A-I      intronic
chr5:133552888(-) A-I      intronic
chr5:133547591(-) A-I      intronic
chr5:133549628(-) A-I      intronic
chr5:133554427(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PPP2CA
chr5:133554436(-) A-I intron -    15342557
chr5:133554445(-) A-I intron -    15342557
chr5:133554589(-) A-I intron -    15342557
chr5:133555620(-) A-I intron -    15342557
chr5:133555671(-) A-I intron -    15342557
chr5:133555924(-) A-I intron -    15342557
chr5:133555967(-) A-I intron -    15342557
chr5:133555978(-) A-I intron -    15342557
chr5:133556068(-) A-I intron -    15342557
chr5:133556073(-) A-I intron -    15342557
chr5:133556142(-) A-I intron -    15342557
chr5:133556850(-) A-I intron -    15342557
chr5:133556899(-) A-I intron -    15342557
chr5:133556900(-) A-I intron -    15342557
chr5:133556967(-) A-I intron -    15342557
chr5:133557024(-) A-I intron -    15342557
chr5:133557626(-) A-I intron -    15342557
chr5:133559480(-) A-I intron -    15342557
chr5:133543400(-) A-I intron -    21960545
chr5:133543520(-) A-I intron -    21960545
chr5:133533962(-) A-G intron -    22484847
chr5:133533972(-) A-G intron -    22484847
chr5:133534548(-) A-G intron -    22484847
chr5:133534690(-) A-G intron -    22484847
chr5:133543013(-) A-G intron -    22484847
chr5:133543014(-) A-G intron -    22484847
chr5:133543019(-) A-G intron -    22484847
chr5:133543473(-) A-G intron -    22484847
chr5:133543520(-) A-G intron -    22484847
chr5:133546424(-) A-G intron -    22484847
chr5:133546898(-) A-G intron -    22484847
chr5:133547395(-) A-G intron -    22484847
chr5:133547434(-) A-G intron -    22484847
chr5:133547439(-) A-G intron -    22484847
chr5:133547552(-) A-G intron -    22484847
chr5:133547558(-) A-G intron -    22484847
chr5:133547591(-) A-G intron -    22484847
chr5:133547641(-) A-G intron -    22484847
chr5:133547646(-) A-G intron -    22484847
chr5:133547689(-) A-G intron -    22484847
chr5:133547716(-) A-G intron -    22484847
chr5:133547753(-) A-G intron -    22484847
chr5:133549768(-) A-G intron -    22484847
chr5:133550864(-) A-G intron -    22484847
chr5:133550899(-) A-G intron -    22484847
chr5:133551183(-) A-G intron -    22484847
chr5:133551329(-) A-G intron -    22484847
chr5:133551338(-) A-G intron -    22484847
chr5:133551405(-) A-G intron -    22484847
chr5:133551425(-) A-G intron -    22484847
chr5:133552888(-) A-G intron -    22484847
chr5:133552895(-) A-G intron -    22484847
chr5:133552968(-) A-G intron -    22484847
chr5:133554427(-) A-G intron -    22484847
chr5:133554436(-) A-G intron -    22484847
chr5:133554445(-) A-G intron -    22484847
chr5:133554498(-) A-G intron -    22484847
chr5:133555620(-) A-G intron -    22484847
chr5:133555967(-) A-G intron -    22484847
chr5:133555993(-) A-G intron -    22484847
chr5:133556073(-) A-G intron -    22484847
chr5:133556941(-) A-G intron -    22484847
chr5:133556947(-) A-G intron -    22484847
chr5:133556967(-) A-G intron -    22484847
chr5:133556974(-) A-G intron -    22484847
chr5:133556977(-) A-G intron -    22484847
chr5:133557590(-) A-G intron -    22484847
chr5:133557596(-) A-G intron -    22484847
chr5:133557597(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PPP2CA
chr5:133532690-133532691(-) m6A 3'UTR       27773535
chr5:133532746-133532747(-) m6A 3'UTR       24981863//27773535//22608085
chr5:133532784-133532785(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr5:133532791-133532792(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr5:133532799-133532800(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr5:133532866-133532867(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr5:133532871-133532872(-) m6A 3'UTR       24284625//24981863//27773535
chr5:133532876-133532877(-) Y 3'UTR       25219674
chr5:133532890-133532891(-) m6A 3'UTR       24284625//24981863//27773535
chr5:133533053-133533054(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr5:133533074-133533075(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr5:133533156-133533157(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:133533177-133533178(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533228-133533229(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533269-133533270(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533337-133533338(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533353-133533354(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533410-133533411(-) Gm 3'UTR//exon       -
chr5:133533429-133533430(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:133533450-133533451(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr5:133533475-133533476(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr5:133534802-133534803(-) m6A CDS//exon       24284625
chr5:133536716-133536717(-) Cm CDS//exon       -
chr5:133539246-133539247(-) m6A exon//intron       26404942
chr5:133541638-133541639(-) m6A CDS//exon       26404942
chr5:133541723-133541724(-) m6A CDS//exon       26404942//27773535
chr5:133560049-133560050(-) m6A 5'UTR//intron       24209618//27773535//27371828//27773536
chr5:133560054-133560055(-) m6A 5'UTR//intron       24209618//27773535//27371828//27773536
chr5:133561520-133561521(-) m6A CDS//exon       24209618//25456834//27773535//27371828//27773536//22575960
chr5:133561639-133561640(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-99a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
PPP2CA
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-99a-3p
Interactor2: PPP2CA

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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