Detail Information

Basic Information:


  VIRBase ID:  

HHID00063907

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92a-2-5p:           PLEKHA1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-92a-2-5p PLEKHA1
miRBase
Accession/Entrez ID		 MIMAT0004508 59338
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TAPP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-92a-2-5p
rs1410543065 chrX:134169584    T/C
rs1472671311 chrX:134169587    T/C
rs377133365 chrX:134169588    G/A
rs377133365 chrX:134169588    G/C
rs745614747 chrX:134169602    C/T
rs769366736 chrX:134169603    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLEKHA1
chr10:124190740(+) A-I      3'UTR
chr10:124190738(+) A-I      3'UTR
chr10:124190737(+) A-I      3'UTR
chr10:124190766(+) A-I      3'UTR
chr10:124190776(+) A-I      3'UTR
chr10:124190770(+) A-I      3'UTR
chr10:124166494(+) A-I      intronic
chr10:124177085(+) A-I      intronic
chr10:124144365(+) A-I      intronic
chr10:124159300(+) A-I      intronic
chr10:124159286(+) A-I      intronic
chr10:124144938(+) A-I      intronic
chr10:124144374(+) A-I      intronic
chr10:124142905(+) A-I      intronic
chr10:124144999(+) A-I      intronic
chr10:124144937(+) A-I      intronic
chr10:124144311(+) A-I      intronic
chr10:124179534(+) A-I      ncRNA
chr10:124185117(+) A-I      ncRNA
chr10:124144075(+) A-I      intronic
chr10:124144951(+) A-I      intronic
chr10:124145015(+) A-I      intronic
chr10:124144392(+) A-I      intronic
chr10:124144305(+) A-I      intronic
chr10:124144998(+) A-I      intronic
chr10:124142872(+) A-I      intronic
chr10:124144259(+) A-I      intronic
chr10:124142899(+) A-I      intronic
chr10:124144973(+) A-I      intronic
chr10:124138141(+) A-I      intronic
chr10:124144978(+) A-I      intronic
chr10:124144352(+) A-I      intronic
chr10:124144934(+) A-I      intronic
chr10:124144207(+) A-I      intronic
chr10:124142975(+) A-I      intronic
chr10:124144384(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHA1
chr10:124175460-124175461(+) m6A CDS//exon       27773535
chr10:124189168-124189169(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr10:124189302-124189303(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189316-124189317(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189333-124189334(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189354-124189355(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189369-124189370(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189416-124189417(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr10:124189596-124189597(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-92a-2-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Cell line (HEK-293)     22984580
PLEKHA1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-92a-2-5p
Diethylstilbestrol 448537 Drug interaction    RC00006830
Carboplatinum 38904 Drug interaction    RC00006829
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006828
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-92a-2-5p
Carboplatin 426756       20548249

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-92a-2-5p
Interactor2: PLEKHA1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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