Basic Information:

  VIRBase ID:  

HHID00063767

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92a-1-5p:  MIMAT0004507          VANGL1:  NM_138959     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-92a-1-5p	VANGL1
miRBase Accession/Entrez ID	MIMAT0004507	81839
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KITENIN//LPP2//STB2//STBM2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-92a-1-5p	rs1418785003 chr13:91351346    T/C rs72631821 chr13:91351334    C/G rs72631821 chr13:91351334    C/T rs778492035 chr13:91351342    A/G rs9589207 chr13:91351335    G/A rs9589207 chr13:91351335    G/C rs887397729 chr13:91351327    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VANGL1	chr1:116238436(+) A-I      3'UTR chr1:116224285(+) A-I      intronic chr1:116231597(+) A-I      intronic chr1:116224275(+) A-I      intronic chr1:116231634(+) A-I      intronic chr1:116231619(+) A-I      intronic chr1:116216495(+) A-I      intronic chr1:116230490(+) A-I      intronic chr1:116230432(+) A-I      intronic chr1:116229327(+) A-I      intronic chr1:116197088(+) A-I      intronic chr1:116230515(+) A-I      intronic chr1:116204507(+) A-I      intronic chr1:116229325(+) A-I      intronic chr1:116237239(+) A-I      3'UTR chr1:116217907(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VANGL1	chr1:116237239(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VANGL1	chr1:116184671-116184672(+) m6A 5'UTR       24981863 chr1:116194099-116194100(+) m6A CDS       24981863 chr1:116202268-116202269(+) m6A CDS       24284625//24981863 chr1:116202279-116202280(+) m6A CDS       24284625//24981863 chr1:116202379-116202380(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:116206299-116206300(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116206348-116206349(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116206369-116206370(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116206378-116206379(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116206436-116206437(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116206553-116206554(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:116206575-116206576(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:116206705-116206706(+) m6A CDS       24284625//24209618 chr1:116206714-116206715(+) m6A CDS       24284625//24209618 chr1:116225030-116225031(+) Y CDS//exon       26075521 chr1:116227999-116228000(+) m6A CDS       24284625//24209618 chr1:116228080-116228081(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:116233791-116233792(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:116233884-116233885(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:116233947-116233948(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr1:116233988-116233989(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr1:116234110-116234111(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:116234223-116234224(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:116234267-116234268(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:116234370-116234371(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr1:116234381-116234382(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr1:116234406-116234407(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr1:116234615-116234616(+) m6A 3'UTR       24284625 chr1:116235034-116235035(+) m6A 3'UTR       24284625 chr1:116235039-116235040(+) m6A 3'UTR       24284625 chr1:116235130-116235131(+) m6A 3'UTR       24284625 chr1:116235195-116235196(+) m6A 3'UTR       24284625//24981863 chr1:116235273-116235274(+) m6A 3'UTR       24284625//24981863 chr1:116235318-116235319(+) m6A 3'UTR       25456834 chr1:116235397-116235398(+) m6A 3'UTR       25456834 chr1:116235451-116235452(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-92a-1-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	VANGL1	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-92a-1-5p	Curcumin 969516 Drug interaction    RC00006826 Diethylstilbestrol 448537 Drug interaction    RC00006825 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006824 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00006827

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-92a-1-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-92a-1-5p
Interactor2: VANGL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.