Basic Information:

  VIRBase ID:  

HHID00063748

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-92a-1-5p:  MIMAT0004507          PLEKHA1:  NM_001377247     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-92a-1-5p	PLEKHA1
miRBase Accession/Entrez ID	MIMAT0004507	59338
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TAPP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-92a-1-5p	rs1418785003 chr13:91351346    T/C rs72631821 chr13:91351334    C/G rs72631821 chr13:91351334    C/T rs778492035 chr13:91351342    A/G rs9589207 chr13:91351335    G/A rs9589207 chr13:91351335    G/C rs887397729 chr13:91351327    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLEKHA1	chr10:124190740(+) A-I      3'UTR chr10:124190738(+) A-I      3'UTR chr10:124190737(+) A-I      3'UTR chr10:124190766(+) A-I      3'UTR chr10:124190776(+) A-I      3'UTR chr10:124190770(+) A-I      3'UTR chr10:124166494(+) A-I      intronic chr10:124177085(+) A-I      intronic chr10:124144365(+) A-I      intronic chr10:124159300(+) A-I      intronic chr10:124159286(+) A-I      intronic chr10:124144938(+) A-I      intronic chr10:124144374(+) A-I      intronic chr10:124142905(+) A-I      intronic chr10:124144999(+) A-I      intronic chr10:124144937(+) A-I      intronic chr10:124144311(+) A-I      intronic chr10:124179534(+) A-I      ncRNA chr10:124185117(+) A-I      ncRNA chr10:124144075(+) A-I      intronic chr10:124144951(+) A-I      intronic chr10:124145015(+) A-I      intronic chr10:124144392(+) A-I      intronic chr10:124144305(+) A-I      intronic chr10:124144998(+) A-I      intronic chr10:124142872(+) A-I      intronic chr10:124144259(+) A-I      intronic chr10:124142899(+) A-I      intronic chr10:124144973(+) A-I      intronic chr10:124138141(+) A-I      intronic chr10:124144978(+) A-I      intronic chr10:124144352(+) A-I      intronic chr10:124144934(+) A-I      intronic chr10:124144207(+) A-I      intronic chr10:124142975(+) A-I      intronic chr10:124144384(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLEKHA1	chr10:124175460-124175461(+) m6A CDS//exon       27773535 chr10:124189168-124189169(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr10:124189302-124189303(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189316-124189317(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189333-124189334(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189354-124189355(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189369-124189370(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189416-124189417(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189596-124189597(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-92a-1-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PLEKHA1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-92a-1-5p	Curcumin 969516 Drug interaction    RC00006826 Diethylstilbestrol 448537 Drug interaction    RC00006825 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006824 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00006827

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-92a-1-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-92a-1-5p
Interactor2: PLEKHA1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.