Detail Information

Basic Information:


  VIRBase ID:  

HHID00063607

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-3p:           PIKFYVE:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-28-3p PIKFYVE
miRBase
Accession/Entrez ID		 MIMAT0004502 200576
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CFD//FAB1//HEL37//PIP5K//PIP5K3//ZFYVE29

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-28-3p
rs1171800557 chr3:188688855    A/C
rs1204710407 chr3:188688834    C/T
rs1403809755 chr3:188688851    C/T
rs368910045 chr3:188688843    G/C
rs368910045 chr3:188688843    G/T
rs375704067 chr3:188688850    C/T
rs750403936 chr3:188688844    T/G
rs758203780 chr3:188688847    G/A
rs78547906 chr3:188688848    C/T
rs1239471924 chr3:188688836    C/A
rs778663459 chr3:188688841    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PIKFYVE
chr2:209221258(+) A-I      3'UTR
chr2:209221257(+) A-I      3'UTR
chr2:209221206(+) A-I      3'UTR
chr2:209221216(+) A-I      3'UTR
chr2:209221219(+) A-I      3'UTR
chr2:209221201(+) A-I      3'UTR
chr2:209221200(+) A-I      3'UTR
chr2:209221264(+) A-I      3'UTR
chr2:209221227(+) A-I      3'UTR
chr2:209221239(+) A-I      3'UTR
chr2:209221223(+) A-I      3'UTR
chr2:209197770(+) A-I      intronic
chr2:209196291(+) A-I      intronic
chr2:209196202(+) A-I      intronic
chr2:209196201(+) A-I      intronic
chr2:209171602(+) A-I      intronic
chr2:209221249(+) A-I      3'UTR
chr2:209172877(+) A-I      intronic
chr2:209221267(+) A-I      3'UTR
chr2:209221263(+) A-I      3'UTR
chr2:209172963(+) A-I      intronic
chr2:209173641(+) A-I      intronic
chr2:209173654(+) A-I      intronic
chr2:209173679(+) A-I      intronic
chr2:209173692(+) A-I      intronic
chr2:209173693(+) A-I      intronic
chr2:209173703(+) A-I      intronic
chr2:209179546(+) A-I      intronic
chr2:209202729(+) A-I      intronic
chr2:209205922(+) A-I      intronic
chr2:209172873(+) A-I      intronic
chr2:209172868(+) A-I      intronic
chr2:209186922(+) A-I      intronic
chr2:209186395(+) A-I      intronic
chr2:209172974(+) A-I      intronic
chr2:209173070(+) A-I      intronic
chr2:209173557(+) A-I      intronic
chr2:209173708(+) A-I      intronic
chr2:209196125(+) A-I      intronic
chr2:209173612(+) A-I      intronic
chr2:209172967(+) A-I      intronic
chr2:209172894(+) A-I      intronic
chr2:209172851(+) A-I      intronic
chr2:209164642(+) A-I      intronic
chr2:209173045(+) A-I      intronic
chr2:209172945(+) A-I      intronic
chr2:209221357(+) A-I      3'UTR
chr2:209173573(+) A-I      intronic
chr2:209173571(+) A-I      intronic
chr2:209186984(+) A-I      intronic
chr2:209172908(+) A-I      intronic
chr2:209173488(+) A-I      intronic
chr2:209172958(+) A-I      intronic
chr2:209186948(+) A-I      intronic
chr2:209197969(+) A-I      intronic
chr2:209187038(+) A-I      intronic
chr2:209186845(+) A-I      intronic
chr2:209171725(+) A-I      intronic
chr2:209173666(+) A-I      intronic
chr2:209187022(+) A-I      intronic
chr2:209172975(+) A-I      intronic
chr2:209186504(+) A-I      intronic
chr2:209173558(+) A-I      intronic
chr2:209186484(+) A-I      intronic
chr2:209213215(+) A-I      intronic
chr2:209186918(+) A-I      intronic
chr2:209173629(+) A-I      intronic
chr2:209173706(+) A-I      intronic
chr2:209187000(+) A-I      intronic
chr2:209171677(+) A-I      intronic
chr2:209172978(+) A-I      intronic
chr2:209173606(+) A-I      intronic
chr2:209173694(+) A-I      intronic
chr2:209173034(+) A-I      intronic
chr2:209186958(+) A-I      intronic
chr2:209197771(+) A-I      intronic
chr2:209172844(+) A-I      intronic
chr2:209173597(+) A-I      intronic
chr2:209172961(+) A-I      intronic
chr2:209172867(+) A-I      intronic
chr2:209135605(+) A-I      intronic
chr2:209186441(+) A-I      intronic
chr2:209172932(+) A-I      intronic
chr2:209171683(+) A-I      intronic
chr2:209196230(+) A-I      intronic
chr2:209173512(+) A-I      intronic
chr2:209171785(+) A-I      intronic
chr2:209173621(+) A-I      intronic
chr2:209196306(+) A-I      intronic
chr2:209173450(+) A-I      intronic
chr2:209172944(+) A-I      intronic
chr2:209173010(+) A-I      intronic
chr2:209213885(+) A-I      intronic
chr2:209173678(+) A-I      intronic
chr2:209197811(+) A-I      intronic
chr2:209173457(+) A-I      intronic
chr2:209186402(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PIKFYVE
chr2:209172805(+) A-G intron -    22484847
chr2:209150008(+) T-C intron -    22484847
chr2:209171516(+) C-T intron -    22484847
chr2:209172844(+) A-G intron -    22484847
chr2:209172851(+) A-G intron -    22484847
chr2:209172867(+) A-G intron -    22484847
chr2:209172868(+) A-G intron -    22484847
chr2:209172932(+) A-G intron -    22484847
chr2:209172958(+) A-G intron -    22484847
chr2:209172964(+) A-G intron -    22484847
chr2:209172965(+) A-G intron -    22484847
chr2:209172967(+) A-G intron -    22484847
chr2:209172975(+) A-G intron -    22484847
chr2:209172978(+) A-G intron -    22484847
chr2:209173045(+) A-G intron -    22484847
chr2:209173449(+) G-T intron -    22484847
chr2:209173457(+) A-G intron -    22484847
chr2:209173488(+) A-G intron -    22484847
chr2:209173549(+) A-G intron -    22484847
chr2:209173558(+) A-G intron -    22484847
chr2:209173597(+) A-G intron -    22484847
chr2:209173598(+) A-G intron -    22484847
chr2:209173606(+) A-G intron -    22484847
chr2:209173621(+) A-G intron -    22484847
chr2:209173666(+) A-G intron -    22484847
chr2:209173678(+) A-G intron -    22484847
chr2:209173694(+) A-G intron -    22484847
chr2:209173706(+) A-G intron -    22484847
chr2:209173708(+) A-G intron -    22484847
chr2:209186320(+) A-T intron -    22484847
chr2:209186395(+) A-G intron -    22484847
chr2:209186402(+) A-G intron -    22484847
chr2:209186441(+) A-G intron -    22484847
chr2:209186484(+) A-G intron -    22484847
chr2:209186504(+) A-G intron -    22484847
chr2:209186835(+) A-G intron -    22484847
chr2:209186922(+) A-G intron -    22484847
chr2:209186958(+) A-G intron -    22484847
chr2:209187000(+) A-G intron -    22484847
chr2:209187022(+) A-G intron -    22484847
chr2:209197773(+) A-G intron -    22484847
chr2:209207537(+) G-T intron -    22484847
chr2:209221104(+) C-T intron -    22484847
chr2:209221234(+) T-C intron -    22484847
chr2:209173389(+) G-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PIKFYVE
chr2:209190405-209190406(+) m6A 3'UTR//CDS       24284625//22608085
chr2:209190526-209190527(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr2:209190538-209190539(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr2:209190584-209190585(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr2:209190652-209190653(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085
chr2:209190726-209190727(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085
chr2:209190833-209190834(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:209190846-209190847(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:209190870-209190871(+) m6A CDS       24284625//24981863//22608085
chr2:209191037-209191038(+) m6A CDS       24284625
chr2:209203272-209203273(+) m6A CDS       24981863
chr2:209212620-209212621(+) m6A CDS       24981863
chr2:209212662-209212663(+) m6A CDS       24981863
chr2:209219305-209219306(+) m6A CDS       24209618//22608085
chr2:209219318-209219319(+) m6A CDS       24284625//24209618//24981863//22608085
chr2:209219364-209219365(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr2:209219951-209219952(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:209219973-209219974(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:209219997-209219998(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:209220005-209220006(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:209220053-209220054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:209220071-209220072(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr2:209220077-209220078(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr2:209220084-209220085(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr2:209220165-209220166(+) m6A 3'UTR       24284625//24981863//22608085
chr2:209220188-209220189(+) m6A 3'UTR       24284625//24981863//22608085
chr2:209221367-209221368(+) m6A 3'UTR       24981863
chr2:209221380-209221381(+) m6A 3'UTR       24981863
chr2:209221390-209221391(+) m6A 3'UTR       24981863
chr2:209221420-209221421(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-28-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Blood|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Neural progenitor cells     21363885
PIKFYVE
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-28-3p
Doxorubicin 31703       25698578
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-28-3p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-28-3p
Interactor2: PIKFYVE

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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