Basic Information:

  VIRBase ID:  

HHID00063606

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-3p:  MIMAT0004502          ZFYVE21:  NM_001198953     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-28-3p	ZFYVE21
miRBase Accession/Entrez ID	MIMAT0004502	79038
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCVP7TP1//ZF21

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-28-3p	rs1171800557 chr3:188688855    A/C rs1204710407 chr3:188688834    C/T rs1403809755 chr3:188688851    C/T rs368910045 chr3:188688843    G/C rs368910045 chr3:188688843    G/T rs375704067 chr3:188688850    C/T rs750403936 chr3:188688844    T/G rs758203780 chr3:188688847    G/A rs78547906 chr3:188688848    C/T rs1239471924 chr3:188688836    C/A rs778663459 chr3:188688841    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE21	chr14:104185726(+) A-I      intronic chr14:104189052(+) A-I      intronic chr14:104188778(+) A-I      intronic chr14:104188792(+) A-I      intronic chr14:104188893(+) A-I      intronic chr14:104188973(+) A-I      intronic chr14:104185721(+) A-I      intronic chr14:104193483(+) A-I      intronic chr14:104185650(+) A-I      intronic chr14:104185713(+) A-I      intronic chr14:104193492(+) A-I      intronic chr14:104185741(+) A-I      intronic chr14:104193480(+) A-I      intronic chr14:104189097(+) A-I      intronic chr14:104197432(+) A-I      intronic chr14:104188901(+) A-I      intronic chr14:104189035(+) A-I      intronic chr14:104189176(+) A-I      intronic chr14:104189261(+) A-I      intronic chr14:104188818(+) A-I      intronic chr14:104187260(+) A-I      intronic chr14:104188759(+) A-I      intronic chr14:104187183(+) A-I      intronic chr14:104187259(+) A-I      intronic chr14:104188831(+) A-I      intronic chr14:104185780(+) A-I      intronic chr14:104187277(+) A-I      intronic chr14:104188748(+) A-I      intronic chr14:104189101(+) A-I      intronic chr14:104197437(+) A-I      intronic chr14:104188902(+) A-I      intronic chr14:104188821(+) A-I      intronic chr14:104185686(+) A-I      intronic chr14:104188715(+) A-I      intronic chr14:104185494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE21	chr14:104197572(+) A-I intron -    21960545 chr14:104197527(+) G-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE21	chr14:104191030-104191031(+) m6A exon//intron       - chr14:104199347-104199348(+) m6A CDS//exon       24981863 chr14:104199396-104199397(+) m6A 3'UTR//exon       24981863 chr14:104199411-104199412(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-28-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Blood|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Neural progenitor cells     21363885
	ZFYVE21	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-28-3p	Doxorubicin 31703       25698578

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-28-3p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-28-3p
Interactor2: ZFYVE21

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.