Basic Information:

  VIRBase ID:  

HHID00063604

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-3p:  MIMAT0004502          BLOC1S6:  NR_132352     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-28-3p	BLOC1S6
miRBase Accession/Entrez ID	MIMAT0004502	26258
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BLOS6//HPS9//PA//PALLID//PLDN

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-28-3p	rs1171800557 chr3:188688855    A/C rs1204710407 chr3:188688834    C/T rs1403809755 chr3:188688851    C/T rs368910045 chr3:188688843    G/C rs368910045 chr3:188688843    G/T rs375704067 chr3:188688850    C/T rs750403936 chr3:188688844    T/G rs758203780 chr3:188688847    G/A rs78547906 chr3:188688848    C/T rs1239471924 chr3:188688836    C/A rs778663459 chr3:188688841    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BLOC1S6	chr15:45886884(+) A-I      intronic chr15:45886907(+) A-I      intronic chr15:45886921(+) A-I      intronic chr15:45886948(+) A-I      intronic chr15:45888522(+) A-I      intronic chr15:45888624(+) A-I      intronic chr15:45888631(+) A-I      intronic chr15:45889001(+) A-I      intronic chr15:45889039(+) A-I      intronic chr15:45889083(+) A-I      intronic chr15:45889465(+) A-I      intronic chr15:45889493(+) A-I      intronic chr15:45889658(+) A-I      intronic chr15:45889670(+) A-I      intronic chr15:45894149(+) A-I      intronic chr15:45894153(+) A-I      intronic chr15:45894196(+) A-I      intronic chr15:45895653(+) A-I      intronic chr15:45895765(+) A-I      intronic chr15:45889526(+) A-I      intronic chr15:45895726(+) A-I      intronic chr15:45886881(+) A-I      intronic chr15:45886825(+) A-I      intronic chr15:45894132(+) A-I      intronic chr15:45894236(+) A-I      intronic chr15:45889494(+) A-I      intronic chr15:45894356(+) A-I      intronic chr15:45886862(+) A-I      intronic chr15:45894122(+) A-I      intronic chr15:45888987(+) A-I      intronic chr15:45888172(+) A-I      intronic chr15:45889630(+) A-I      intronic chr15:45885372(+) A-I      intronic chr15:45887369(+) A-I      intronic chr15:45885315(+) A-I      intronic chr15:45894205(+) A-I      intronic chr15:45899850(+) A-I      3'UTR chr15:45901393(+) A-I      3'UTR chr15:45901399(+) A-I      3'UTR chr15:45899981(+) A-I      3'UTR chr15:45899764(+) A-I      3'UTR chr15:45899979(+) A-I      3'UTR chr15:45899860(+) A-I      3'UTR chr15:45899915(+) A-I      3'UTR chr15:45892794(+) A-I      intronic chr15:45885585(+) A-I      intronic chr15:45887018(+) A-I      intronic chr15:45886911(+) A-I      intronic chr15:45888902(+) A-I      intronic chr15:45886958(+) A-I      intronic chr15:45888596(+) A-I      intronic chr15:45892805(+) A-I      intronic chr15:45889597(+) A-I      intronic chr15:45896347(+) A-I      intronic chr15:45889048(+) A-I      intronic chr15:45894179(+) A-I      intronic chr15:45895809(+) A-I      intronic chr15:45886924(+) A-I      intronic chr15:45892627(+) A-I      intronic chr15:45896311(+) A-I      intronic chr15:45889556(+) A-I      intronic chr15:45885437(+) A-I      intronic chr15:45889015(+) A-I      intronic chr15:45885527(+) A-I      intronic chr15:45889525(+) A-I      intronic chr15:45886882(+) A-I      intronic chr15:45894178(+) A-I      intronic chr15:45885433(+) A-I      intronic chr15:45892778(+) A-I      intronic chr15:45892764(+) A-I      intronic chr15:45892700(+) A-I      intronic chr15:45889624(+) A-I      intronic chr15:45883700(+) A-I      intronic chr15:45894096(+) A-I      intronic chr15:45889420(+) A-I      intronic chr15:45895646(+) A-I      intronic chr15:45889004(+) A-I      intronic chr15:45889419(+) A-I      intronic chr15:45895652(+) A-I      intronic chr15:45888535(+) A-I      intronic chr15:45896317(+) A-I      intronic chr15:45886947(+) A-I      intronic chr15:45885490(+) A-I      intronic chr15:45885463(+) A-I      intronic chr15:45889518(+) A-I      intronic chr15:45889566(+) A-I      intronic chr15:45894129(+) A-I      intronic chr15:45885434(+) A-I      intronic chr15:45895791(+) A-I      intronic chr15:45894218(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BLOC1S6	chr15:45879387-45879388(+) m6A 5'UTR       24981863 chr15:45879639-45879640(+) m6A 5'UTR//exon       24981863 chr15:45879775-45879776(+) m6A exon//intron       24981863 chr15:45879790-45879791(+) m6A 5'UTR//exon//intron       24981863 chr15:45893461-45893462(+) m6A 5'UTR//intron       24981863 chr15:45893476-45893477(+) m6A 5'UTR//intron       24981863 chr15:45893493-45893494(+) m6A 5'UTR//intron       24981863 chr15:45897639-45897640(+) m6A 3'UTR//CDS//exon//intron       27773535 chr15:45897697-45897698(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr15:45898606-45898607(+) m6A 3'UTR//CDS//exon//intron       24981863 chr15:45898693-45898694(+) m6A 3'UTR//CDS//exon//intron       24981863 chr15:45901095-45901096(+) Y 3'UTR//intron       26075521 chr15:45901484-45901485(+) m6A 3'UTR//intron       27773535 chr15:45901509-45901510(+) m6A 3'UTR//intron       27773535 chr15:45901524-45901525(+) m6A 3'UTR//intron       27773535 chr15:45901529-45901530(+) m6A 3'UTR//intron       27773535 chr15:45901537-45901538(+) m6A 3'UTR//intron       27773535 chr15:45901545-45901546(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-28-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Blood|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Neural progenitor cells     21363885
	BLOC1S6	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-28-3p	Doxorubicin 31703       25698578

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-28-3p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-28-3p
Interactor2: BLOC1S6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.