Basic Information:

  VIRBase ID:  

HHID00063603

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-3p:  MIMAT0004502          SZRD1:  NR_073500     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-28-3p	SZRD1
miRBase Accession/Entrez ID	MIMAT0004502	26099
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf144

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-28-3p	rs1171800557 chr3:188688855    A/C rs1204710407 chr3:188688834    C/T rs1403809755 chr3:188688851    C/T rs368910045 chr3:188688843    G/C rs368910045 chr3:188688843    G/T rs375704067 chr3:188688850    C/T rs750403936 chr3:188688844    T/G rs758203780 chr3:188688847    G/A rs78547906 chr3:188688848    C/T rs1239471924 chr3:188688836    C/A rs778663459 chr3:188688841    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SZRD1	chr1:16719661(+) A-I      intronic chr1:16703882(+) A-I      intronic chr1:16703901(+) A-I      intronic chr1:16700024(+) A-I      intronic chr1:16699898(+) A-I      intronic chr1:16700235(+) A-I      intronic chr1:16700264(+) A-I      intronic chr1:16701442(+) A-I      intronic chr1:16697831(+) A-I      intronic chr1:16701498(+) A-I      intronic chr1:16710831(+) A-I      intronic chr1:16702082(+) A-I      intronic chr1:16707634(+) A-I      intronic chr1:16698712(+) A-I      intronic chr1:16710375(+) A-I      intronic chr1:16705719(+) A-I      intronic chr1:16707519(+) A-I      intronic chr1:16710304(+) A-I      intronic chr1:16705740(+) A-I      intronic chr1:16710373(+) A-I      intronic chr1:16698837(+) A-I      intronic chr1:16698874(+) A-I      intronic chr1:16710298(+) A-I      intronic chr1:16707548(+) A-I      intronic chr1:16699879(+) A-I      intronic chr1:16707815(+) A-I      intronic chr1:16707642(+) A-I      intronic chr1:16710295(+) A-I      intronic chr1:16707683(+) A-I      intronic chr1:16699889(+) A-I      intronic chr1:16707618(+) A-I      intronic chr1:16705741(+) A-I      intronic chr1:16710232(+) A-I      intronic chr1:16705754(+) A-I      intronic chr1:16705780(+) A-I      intronic chr1:16705781(+) A-I      intronic chr1:16709841(+) A-I      intronic chr1:16705799(+) A-I      intronic chr1:16709798(+) A-I      intronic chr1:16706891(+) A-I      intronic chr1:16709769(+) A-I      intronic chr1:16709595(+) A-I      intronic chr1:16709550(+) A-I      intronic chr1:16709478(+) A-I      intronic chr1:16709461(+) A-I      intronic chr1:16709430(+) A-I      intronic chr1:16706901(+) A-I      intronic chr1:16706915(+) A-I      intronic chr1:16707043(+) A-I      intronic chr1:16709211(+) A-I      intronic chr1:16709187(+) A-I      intronic chr1:16708268(+) A-I      intronic chr1:16707064(+) A-I      intronic chr1:16708267(+) A-I      intronic chr1:16707620(+) A-I      intronic chr1:16707105(+) A-I      intronic chr1:16697827(+) A-I      intronic chr1:16707517(+) A-I      intronic chr1:16697803(+) A-I      intronic chr1:16696263(+) A-I      intronic chr1:16697812(+) A-I      intronic chr1:16709053(+) A-I      intronic chr1:16705797(+) A-I      intronic chr1:16696257(+) A-I      intronic chr1:16696106(+) A-I      intronic chr1:16697710(+) A-I      intronic chr1:16708855(+) A-I      intronic chr1:16699954(+) A-I      intronic chr1:16696752(+) A-I      intronic chr1:16700240(+) A-I      intronic chr1:16704919(+) A-I      intronic chr1:16699924(+) A-I      intronic chr1:16699953(+) A-I      intronic chr1:16699825(+) A-I      intronic chr1:16708365(+) A-I      intronic chr1:16698719(+) A-I      intronic chr1:16700053(+) A-I      intronic chr1:16707690(+) A-I      intronic chr1:16700295(+) A-I      intronic chr1:16703902(+) A-I      intronic chr1:16709135(+) A-I      intronic chr1:16708316(+) A-I      intronic chr1:16706724(+) A-I      intronic chr1:16707880(+) A-I      intronic chr1:16697761(+) A-I      intronic chr1:16709500(+) A-I      intronic chr1:16705794(+) A-I      intronic chr1:16708345(+) A-I      intronic chr1:16707041(+) A-I      intronic chr1:16700228(+) A-I      intronic chr1:16703398(+) A-I      intronic chr1:16703913(+) A-I      intronic chr1:16707461(+) A-I      intronic chr1:16707941(+) A-I      intronic chr1:16707626(+) A-I      intronic chr1:16706381(+) A-I      intronic chr1:16696838(+) A-I      intronic chr1:16703918(+) A-I      intronic chr1:16701859(+) A-I      intronic chr1:16703917(+) A-I      intronic chr1:16708172(+) A-I      intronic chr1:16705251(+) A-I      intronic chr1:16709064(+) A-I      intronic chr1:16696213(+) A-I      intronic chr1:16709210(+) A-I      intronic chr1:16708271(+) A-I      intronic chr1:16708269(+) A-I      intronic chr1:16704897(+) A-I      intronic chr1:16707905(+) A-I      intronic chr1:16707103(+) A-I      intronic chr1:16708437(+) A-I      intronic chr1:16696222(+) A-I      intronic chr1:16700216(+) A-I      intronic chr1:16709912(+) A-I      intronic chr1:16703869(+) A-I      intronic chr1:16703892(+) A-I      intronic chr1:16696814(+) A-I      intronic chr1:16710620(+) A-I      intronic chr1:16704972(+) A-I      intronic chr1:16709563(+) A-I      intronic chr1:16708280(+) A-I      intronic chr1:16709953(+) A-I      intronic chr1:16696219(+) A-I      intronic chr1:16705819(+) A-I      intronic chr1:16709409(+) A-I      intronic chr1:16700133(+) A-I      intronic chr1:16701939(+) A-I      intronic chr1:16701556(+) A-I      intronic chr1:16703876(+) A-I      intronic chr1:16704966(+) A-I      intronic chr1:16704884(+) A-I      intronic chr1:16703973(+) A-I      intronic chr1:16698848(+) A-I      intronic chr1:16710851(+) A-I      intronic chr1:16696237(+) A-I      intronic chr1:16702076(+) A-I      intronic chr1:16697783(+) A-I      intronic chr1:16708869(+) A-I      intronic chr1:16709224(+) A-I      intronic chr1:16707462(+) A-I      intronic chr1:16703148(+) A-I      intronic chr1:16707664(+) A-I      intronic chr1:16709084(+) A-I      intronic chr1:16709265(+) A-I      intronic chr1:16696208(+) A-I      intronic chr1:16709544(+) A-I      intronic chr1:16709414(+) A-I      intronic chr1:16710814(+) A-I      intronic chr1:16710784(+) A-I      intronic chr1:16707081(+) A-I      intronic chr1:16696264(+) A-I      intronic chr1:16706714(+) A-I      intronic chr1:16700333(+) A-I      intronic chr1:16700238(+) A-I      intronic chr1:16701634(+) A-I      intronic chr1:16709029(+) A-I      intronic chr1:16705860(+) A-I      intronic chr1:16709129(+) A-I      intronic chr1:16714869(+) A-I      intronic chr1:16706395(+) A-I      intronic chr1:16703822(+) A-I      intronic chr1:16706385(+) A-I      intronic chr1:16703190(+) A-I      intronic chr1:16706937(+) A-I      intronic chr1:16710764(+) A-I      intronic chr1:16709021(+) A-I      intronic chr1:16706940(+) A-I      intronic chr1:16703840(+) A-I      intronic chr1:16707146(+) A-I      intronic chr1:16703243(+) A-I      intronic chr1:16707674(+) A-I      intronic chr1:16708361(+) A-I      intronic chr1:16707323(+) A-I      intronic chr1:16708306(+) A-I      intronic chr1:16703960(+) A-I      intronic chr1:16706927(+) A-I      intronic chr1:16701936(+) A-I      intronic chr1:16703969(+) A-I      intronic chr1:16698847(+) A-I      intronic chr1:16708866(+) A-I      intronic chr1:16709855(+) A-I      intronic chr1:16709877(+) A-I      intronic chr1:16697825(+) A-I      intronic chr1:16708372(+) A-I      intronic chr1:16700328(+) A-I      intronic chr1:16703816(+) A-I      intronic chr1:16703877(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SZRD1	chr1:16693795-16693796(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr1:16694216-16694217(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr1:16717065-16717066(+) m6A exon//intron       24284625//25456834//24981863 chr1:16717072-16717073(+) m6A exon//intron       24284625//25456834//24981863 chr1:16717088-16717089(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr1:16717876-16717877(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr1:16717895-16717896(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22608085 chr1:16719962-16719963(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr1:16721558-16721559(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr1:16721586-16721587(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr1:16721622-16721623(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:16721715-16721716(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:16721723-16721724(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:16721793-16721794(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:16721911-16721912(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:16721922-16721923(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:16721936-16721937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:16722015-16722016(+) m6A 3'UTR       27773535 chr1:16722027-16722028(+) m6A 3'UTR       27773535 chr1:16722253-16722254(+) m6A 3'UTR       - chr1:16722338-16722339(+) m6A 3'UTR       - chr1:16722737-16722738(+) m6A 3'UTR       27773535 chr1:16723016-16723017(+) m6A 3'UTR       24284625 chr1:16723115-16723116(+) m6A 3'UTR       24284625 chr1:16723847-16723848(+) m6A 3'UTR       - chr1:16723854-16723855(+) m6A 3'UTR       - chr1:16724008-16724009(+) m6A 3'UTR       - chr1:16724032-16724033(+) m6A 3'UTR       24284625 chr1:16724117-16724118(+) m6A 3'UTR       24284625 chr1:16724406-16724407(+) m6A 3'UTR       24284625 chr1:16724415-16724416(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-28-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Blood|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Neural progenitor cells     21363885
	SZRD1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-28-3p	Doxorubicin 31703       25698578

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-28-3p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-28-3p
Interactor2: SZRD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.