Basic Information:

  VIRBase ID:  

HHID00063594

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26b-3p:  MIMAT0004500          EPC2:  NM_015630     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26b-3p	EPC2
miRBase Accession/Entrez ID	MIMAT0004500	26122
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EPC-LIKE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26b-3p	rs373131632 chr2:218402710    G/A rs752111841 chr2:218402711    C/G rs752111841 chr2:218402711    C/T rs752183955 chr2:218402700    C/G rs757962316 chr2:218402701    C/T rs912863478 chr2:218402692    C/A rs912863478 chr2:218402692    C/T rs1233068699 chr2:218402699    T/G rs1354053050 chr2:218402695    GTT/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EPC2	chr2:149533504(+) A-I      intronic chr2:149461215(+) A-I      intronic chr2:149453756(+) A-I      intronic chr2:149421813(+) A-I      intronic chr2:149533476(+) A-I      intronic chr2:149515334(+) A-I      intronic chr2:149515299(+) A-I      intronic chr2:149515339(+) A-I      intronic chr2:149515354(+) A-I      intronic chr2:149515295(+) A-I      intronic chr2:149486195(+) A-I      intronic chr2:149515331(+) A-I      intronic chr2:149515327(+) A-I      intronic chr2:149517616(+) A-I      intronic chr2:149517663(+) A-I      intronic chr2:149517665(+) A-I      intronic chr2:149533464(+) A-I      intronic chr2:149515312(+) A-I      intronic chr2:149461362(+) A-I      intronic chr2:149485620(+) A-I      intronic chr2:149485688(+) A-I      intronic chr2:149485692(+) A-I      intronic chr2:149485739(+) A-I      intronic chr2:149485778(+) A-I      intronic chr2:149486048(+) A-I      intronic chr2:149486094(+) A-I      intronic chr2:149534703(+) A-I      intronic chr2:149534689(+) A-I      intronic chr2:149534643(+) A-I      intronic chr2:149534626(+) A-I      intronic chr2:149534609(+) A-I      intronic chr2:149532623(+) A-I      intronic chr2:149532603(+) A-I      intronic chr2:149532602(+) A-I      intronic chr2:149532579(+) A-I      intronic chr2:149532567(+) A-I      intronic chr2:149532564(+) A-I      intronic chr2:149517662(+) A-I      intronic chr2:149516827(+) A-I      intronic chr2:149516819(+) A-I      intronic chr2:149516787(+) A-I      intronic chr2:149516748(+) A-I      intronic chr2:149461321(+) A-I      intronic chr2:149486119(+) A-I      intronic chr2:149486100(+) A-I      intronic chr2:149515192(+) A-I      intronic chr2:149515143(+) A-I      intronic chr2:149514699(+) A-I      intronic chr2:149489233(+) A-I      intronic chr2:149489133(+) A-I      intronic chr2:149489111(+) A-I      intronic chr2:149489099(+) A-I      intronic chr2:149489089(+) A-I      intronic chr2:149486611(+) A-I      intronic chr2:149486551(+) A-I      intronic chr2:149486178(+) A-I      intronic chr2:149404426(+) A-I      intronic chr2:149404503(+) A-I      intronic chr2:149404523(+) A-I      intronic chr2:149404526(+) A-I      intronic chr2:149404527(+) A-I      intronic chr2:149404933(+) A-I      intronic chr2:149404970(+) A-I      intronic chr2:149404976(+) A-I      intronic chr2:149405013(+) A-I      intronic chr2:149412181(+) A-I      intronic chr2:149412187(+) A-I      intronic chr2:149412192(+) A-I      intronic chr2:149420839(+) A-I      intronic chr2:149420969(+) A-I      intronic chr2:149420972(+) A-I      intronic chr2:149420994(+) A-I      intronic chr2:149421009(+) A-I      intronic chr2:149421026(+) A-I      intronic chr2:149421812(+) A-I      intronic chr2:149421821(+) A-I      intronic chr2:149421906(+) A-I      intronic chr2:149421909(+) A-I      intronic chr2:149421912(+) A-I      intronic chr2:149428371(+) A-I      intronic chr2:149428372(+) A-I      intronic chr2:149435037(+) A-I      intronic chr2:149435042(+) A-I      intronic chr2:149435043(+) A-I      intronic chr2:149452398(+) A-I      intronic chr2:149452442(+) A-I      intronic chr2:149452459(+) A-I      intronic chr2:149452466(+) A-I      intronic chr2:149452525(+) A-I      intronic chr2:149452531(+) A-I      intronic chr2:149452542(+) A-I      intronic chr2:149452446(+) A-I      intronic chr2:149533486(+) A-I      intronic chr2:149532511(+) A-I      intronic chr2:149427006(+) A-I      intronic chr2:149461198(+) A-I      intronic chr2:149456084(+) A-I      intronic chr2:149421946(+) A-I      intronic chr2:149412045(+) A-I      intronic chr2:149404600(+) A-I      intronic chr2:149486050(+) A-I      intronic chr2:149405367(+) A-I      intronic chr2:149534663(+) A-I      intronic chr2:149532537(+) A-I      intronic chr2:149517758(+) A-I      intronic chr2:149513358(+) A-I      intronic chr2:149405412(+) A-I      intronic chr2:149485749(+) A-I      intronic chr2:149412173(+) A-I      intronic chr2:149429163(+) A-I      intronic chr2:149515336(+) A-I      intronic chr2:149515246(+) A-I      intronic chr2:149516761(+) A-I      intronic chr2:149540027(+) A-I      intronic chr2:149514691(+) A-I      intronic chr2:149486057(+) A-I      intronic chr2:149405382(+) A-I      intronic chr2:149533535(+) A-I      intronic chr2:149452360(+) A-I      intronic chr2:149540055(+) A-I      intronic chr2:149517661(+) A-I      intronic chr2:149513363(+) A-I      intronic chr2:149517660(+) A-I      intronic chr2:149421908(+) A-I      intronic chr2:149536882(+) A-I      intronic chr2:149470234(+) A-I      intronic chr2:149524497(+) A-I      intronic chr2:149534614(+) A-I      intronic chr2:149436557(+) A-I      intronic chr2:149533512(+) A-I      intronic chr2:149513396(+) A-I      intronic chr2:149516679(+) A-I      intronic chr2:149516104(+) A-I      intronic chr2:149516762(+) A-I      intronic chr2:149452557(+) A-I      intronic chr2:149486232(+) A-I      intronic chr2:149486188(+) A-I      intronic chr2:149534354(+) A-I      intronic chr2:149456114(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EPC2	chr2:149516679(+) A-G intron -    22484847 chr2:149516687(+) A-G intron -    22484847 chr2:149516761(+) A-G intron -    22484847 chr2:149516762(+) A-G intron -    22484847 chr2:149517747(+) A-G intron -    22484847 chr2:149517758(+) A-G intron -    22484847 chr2:149534354(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EPC2	chr2:149402583-149402584(+) m6A 5'UTR//intron       24209618 chr2:149402594-149402595(+) m6A CDS//intron       24209618 chr2:149402656-149402657(+) m6A 5'UTR//CDS       24209618 chr2:149511586-149511587(+) m6A CDS//exon       27773535 chr2:149511620-149511621(+) m6A CDS//exon       24981863//27773535 chr2:149511678-149511679(+) m6A CDS//exon       24981863//27773535 chr2:149511693-149511694(+) m6A CDS//exon       24981863//27773535 chr2:149519391-149519392(+) m6A CDS//exon       24981863//27773535 chr2:149519452-149519453(+) m6A CDS//exon       24981863//27773535 chr2:149520365-149520366(+) m6A CDS       24981863 chr2:149528623-149528624(+) m6A CDS       24981863//22608085 chr2:149528639-149528640(+) m6A CDS       24981863//22608085 chr2:149528657-149528658(+) m6A CDS       24981863//22608085 chr2:149528665-149528666(+) m6A CDS       24981863//22608085 chr2:149528703-149528704(+) m6A CDS       24981863//22608085 chr2:149528710-149528711(+) m6A CDS       24981863//22608085 chr2:149528733-149528734(+) m6A CDS       24981863//22608085 chr2:149528750-149528751(+) m6A CDS       24981863//27773535//22608085 chr2:149528765-149528766(+) m6A CDS       24981863//27773535//22608085 chr2:149528845-149528846(+) m6A CDS       24981863//22608085 chr2:149528876-149528877(+) m6A CDS       24981863//22608085 chr2:149528886-149528887(+) m6A CDS       24981863//22608085 chr2:149528893-149528894(+) m6A CDS       24981863//22608085 chr2:149528932-149528933(+) m6A CDS       24981863//22608085 chr2:149541278-149541279(+) m6A CDS       24284625//22608085 chr2:149541283-149541284(+) m6A CDS       24284625//22608085 chr2:149542238-149542239(+) m6A CDS       24284625//24981863//22608085 chr2:149542247-149542248(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:149542313-149542314(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr2:149542335-149542336(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr2:149542373-149542374(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr2:149542386-149542387(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr2:149542466-149542467(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr2:149542495-149542496(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr2:149542521-149542522(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:149543878-149543879(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:149543885-149543886(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:149543919-149543920(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:149543952-149543953(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:149544048-149544049(+) m6A 3'UTR       24981863//27773535//22575960//22608085 chr2:149544058-149544059(+) m6A 3'UTR       24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26b-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	EPC2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26b-3p
Interactor2: EPC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.