Detail Information

Basic Information:


  VIRBase ID:  

HHID00063318

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-2-5p:           MAP2K3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19b-2-5p MAP2K3
miRBase
Accession/Entrez ID
MIMAT0004492 5606
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MAPKK3//MEK3//MKK3//PRKMK3//SAPKK-2//SAPKK2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19b-2-5p
rs193073651 chrX:134169728    G/A
rs749008511 chrX:134169737    A/C
rs755951722 chrX:134169731    A/G
rs779795647 chrX:134169732    T/C
rs747654746 chrX:134169746    A/G
rs754566533 chrX:134169743    A/G
rs778397250 chrX:134169744    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAP2K3
chr17:21211660(+) A-I      intronic
chr17:21211643(+) A-I      intronic
chr17:21211577(+) A-I      intronic
chr17:21195761(+) A-I      intronic
chr17:21195794(+) A-I      intronic
chr17:21194142(+) A-I      intronic
chr17:21195982(+) A-I      intronic
chr17:21216080(+) A-I      intronic
chr17:21216077(+) A-I      intronic
chr17:21194080(+) A-I      intronic
chr17:21195799(+) A-I      intronic
chr17:21195798(+) A-I      intronic
chr17:21195924(+) A-I      intronic
chr17:21195939(+) A-I      intronic
chr17:21211508(+) A-I      intronic
chr17:21195866(+) A-I      intronic
chr17:21195891(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAP2K3
chr17:21188050-21188051(+) m6A 5'UTR//exon       24209618
chr17:21188219-21188220(+) m6A 5'UTR//exon       24284625//24209618//22575960
chr17:21191305-21191306(+) m6A CDS//intron       24284625
chr17:21199460-21199461(+) m6A 3'UTR//5'UTR//CDS//intron       -
chr17:21202200-21202201(+) m6A 3'UTR//CDS//exon       24284625//24981863
chr17:21202206-21202207(+) m6A 3'UTR//CDS//exon       24284625//24981863
chr17:21202214-21202215(+) m6A 3'UTR//CDS//exon       24284625//24981863
chr17:21202233-21202234(+) m6A 3'UTR//CDS//exon       24284625//24981863
chr17:21203808-21203809(+) m6A exon//intron       24284625
chr17:21203857-21203858(+) m6A 3'UTR//CDS//exon       24284625
chr17:21203897-21203898(+) m6A 3'UTR//CDS//exon       24284625
chr17:21204204-21204205(+) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:21204234-21204235(+) m6A 3'UTR//CDS       24284625//22575960
chr17:21204240-21204241(+) m6A 3'UTR//CDS       24284625//22575960
chr17:21205485-21205486(+) m6A 3'UTR//CDS       24284625
chr17:21205497-21205498(+) m6A 3'UTR//CDS       24284625
chr17:21205527-21205528(+) m6A 3'UTR//CDS       24284625
chr17:21205545-21205546(+) m6A 3'UTR//CDS       24284625
chr17:21207818-21207819(+) m6A 3'UTR//CDS       24284625
chr17:21208387-21208388(+) m6A 3'UTR//CDS       24284625//24981863
chr17:21215074-21215075(+) m6A exon//intron       24284625
chr17:21215577-21215578(+) m6A 3'UTR//CDS//exon       24284625
chr17:21216814-21216815(+) m6A 3'UTR//CDS//exon       24284625
chr17:21217138-21217139(+) m6A 3'UTR//intron       25456834
chr17:21217485-21217486(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942
chr17:21217498-21217499(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942
chr17:21217534-21217535(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942
chr17:21217556-21217557(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960
chr17:21217657-21217658(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960
chr17:21217721-21217722(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:21217785-21217786(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr17:21217812-21217813(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr17:21217952-21217953(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960
chr17:21218044-21218045(+) m6A 3'UTR       24284625
chr17:21218099-21218100(+) m6A 3'UTR       24284625
chr17:21218388-21218389(+) m6A 3'UTR       24284625//24981863//26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19b-2-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MAP2K3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19b-2-5p
Interactor2: MAP2K3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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