Basic Information:

  VIRBase ID:  

HHID00063266

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          PLCXD2:  NM_001185106     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	PLCXD2
miRBase Accession/Entrez ID	MIMAT0004491	257068
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLCXD2	chr3:111437152(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLCXD2	chr3:111393867-111393868(+) m6A 5'UTR       24981863 chr3:111393917-111393918(+) m6A 5'UTR       24981863 chr3:111393987-111393988(+) m6A 5'UTR       24981863//22608085 chr3:111426831-111426832(+) m6A 5'UTR//CDS       22608085 chr3:111426904-111426905(+) m6A CDS       22608085 chr3:111426920-111426921(+) m6A CDS       24981863//22608085 chr3:111426968-111426969(+) m6A CDS       24981863//22608085 chr3:111427119-111427120(+) m6A CDS       24284625//24981863//22608085 chr3:111427165-111427166(+) m6A CDS       24284625 chr3:111432959-111432960(+) m6A CDS//exon       24981863 chr3:111439589-111439590(+) m6A exon//intron       24981863 chr3:111439600-111439601(+) m6A exon//intron       24981863 chr3:111439652-111439653(+) m6A exon//intron       24981863 chr3:111439661-111439662(+) m6A exon//intron       24981863 chr3:111439706-111439707(+) m6A exon//intron       24981863 chr3:111451393-111451394(+) m6A exon//intron       24981863//27773535 chr3:111451424-111451425(+) m6A exon//intron       24981863//27773535 chr3:111451476-111451477(+) m6A CDS//exon//intron       24981863//27773535 chr3:111451545-111451546(+) m6A 3'UTR//exon//intron       24981863//27773535 chr3:111497124-111497125(+) m6A exon//intron       27773535 chr3:111497143-111497144(+) m6A exon//intron       27773535 chr3:111497154-111497155(+) m6A exon//intron       27773535 chr3:111497227-111497228(+) m6A exon//intron       27773535 chr3:111497255-111497256(+) m6A exon//intron       27773535 chr3:111497271-111497272(+) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	PLCXD2	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: PLCXD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.