Basic Information:

  VIRBase ID:  

HHID00063062

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          ID2:  NM_002166     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	ID2
miRBase Accession/Entrez ID	MIMAT0004491	3398
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bHLHb26//GIG8//ID2A//ID2H

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ID2	chr2:8823570(+) A-I      intronic chr2:8823643(+) A-I      intronic chr2:8823637(+) A-I      intronic chr2:8823631(+) A-I      intronic chr2:8823591(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ID2	chr2:8822332-8822333(+) m6A CDS       24981863 chr2:8822344-8822345(+) m6A CDS       24981863 chr2:8822373-8822374(+) m6A CDS       - chr2:8822461-8822462(+) m6A CDS       - chr2:8823067-8823068(+) m6A 3'UTR//intron       27773535//22608085 chr2:8823885-8823886(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8823914-8823915(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8823927-8823928(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8823961-8823962(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8824001-8824002(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8824029-8824030(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8824133-8824134(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr2:8824286-8824287(+) m6A 3'UTR       27773535 chr2:8824295-8824296(+) m6A 3'UTR       27773535 chr2:8824380-8824381(+) m6A 3'UTR       27773535 chr2:8824405-8824406(+) m6A 3'UTR       27773535 chr2:8824475-8824476(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ID2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: ID2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.