Basic Information:

  VIRBase ID:  

HHID00062974

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          IAH1:  NM_001320860     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	IAH1
miRBase Accession/Entrez ID	MIMAT0004489	285148
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IAH1	chr2:9626838(+) A-I      intronic chr2:9626837(+) A-I      intronic chr2:9626815(+) A-I      intronic chr2:9626800(+) A-I      intronic chr2:9626827(+) A-I      intronic chr2:9626864(+) A-I      intronic chr2:9626869(+) A-I      intronic chr2:9636480(+) A-I      3'UTR chr2:9636448(+) A-I      3'UTR chr2:9625662(+) A-I      intronic chr2:9620568(+) A-I      intronic chr2:9628063(+) A-I      intronic chr2:9627263(+) A-I      intronic chr2:9628120(+) A-I      intronic chr2:9628089(+) A-I      intronic chr2:9628092(+) A-I      intronic chr2:9626879(+) A-I      intronic chr2:9636306(+) A-I      intronic chr2:9626808(+) A-I      intronic chr2:9627281(+) A-I      intronic chr2:9628115(+) A-I      intronic chr2:9636338(+) A-I      intronic chr2:9636469(+) A-I      3'UTR chr2:9636494(+) A-I      3'UTR chr2:9636506(+) A-I      3'UTR chr2:9636481(+) A-I      3'UTR chr2:9620031(+) A-I      intronic chr2:9620404(+) A-I      intronic chr2:9628088(+) A-I      intronic chr2:9623395(+) A-I      intronic chr2:9619989(+) A-I      intronic chr2:9619963(+) A-I      intronic chr2:9628100(+) A-I      intronic chr2:9620376(+) A-I      intronic chr2:9625618(+) A-I      intronic chr2:9628169(+) A-I      intronic chr2:9628102(+) A-I      intronic chr2:9625606(+) A-I      intronic chr2:9636442(+) A-I      intronic chr2:9620520(+) A-I      intronic chr2:9635722(+) A-I      intronic chr2:9620524(+) A-I      intronic chr2:9628214(+) A-I      intronic chr2:9636358(+) A-I      intronic chr2:9636361(+) A-I      intronic chr2:9620554(+) A-I      intronic chr2:9620079(+) A-I      intronic chr2:9627280(+) A-I      intronic chr2:9626802(+) A-I      intronic chr2:9628075(+) A-I      intronic chr2:9625663(+) A-I      intronic chr2:9626699(+) A-I      intronic chr2:9628187(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IAH1	chr2:9620031(+) A-G intron -    22484847 chr2:9620035(+) T-C intron -    22484847 chr2:9620524(+) A-G intron -    22484847 chr2:9620554(+) A-G intron -    22484847 chr2:9628060(+) T-C intron -    22484847 chr2:9628061(+) T-C intron -    22484847 chr2:9628063(+) A-G intron -    22484847 chr2:9628078(+) T-C intron -    22484847 chr2:9628084(+) T-C intron -    22484847 chr2:9628109(+) T-C intron -    22484847 chr2:9628110(+) T-C intron -    22484847 chr2:9628120(+) A-G intron -    22484847 chr2:9628226(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IAH1	chr2:9618436-9618437(+) m6A 3'UTR//5'UTR//CDS//exon       - chr2:9618445-9618446(+) m6A 3'UTR//5'UTR//CDS//exon       - chr2:9621004-9621005(+) m6A exon//intron       - chr2:9628301-9628302(+) m6A 3'UTR//CDS//exon       24284625 chr2:9628421-9628422(+) m6A 3'UTR//CDS//exon       24284625 chr2:9628450-9628451(+) m6A 3'UTR//CDS//exon       24284625 chr2:9628471-9628472(+) m6A 3'UTR//exon       24284625 chr2:9628497-9628498(+) m6A 3'UTR//exon       24284625 chr2:9628545-9628546(+) m6A 3'UTR//exon//intron       24284625 chr2:9629211-9629212(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	IAH1	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: IAH1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.