Detail Information

Basic Information:


  VIRBase ID:  

HHID00062711

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-15a-3p:           TMEM64:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-15a-3p TMEM64
miRBase
Accession/Entrez ID		 MIMAT0004488 169200
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-15a-3p
rs1005480841 chr13:50049132    A/G
rs1418123391 chr13:50049142    A/T
rs769107331 chr13:50049130    T/C
rs774886958 chr13:50049138    C/T
rs762130418 chr13:50049146    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM64
chr8:91634346-91634347(-) m6A 3'UTR       27773535
chr8:91637789-91637790(-) m6A 3'UTR       24981863
chr8:91637794-91637795(-) m6A 3'UTR       24981863
chr8:91637821-91637822(-) m6A 3'UTR       24284625//24981863//22608085
chr8:91637936-91637937(-) m6A CDS       24284625//24981863//26404942//22608085
chr8:91638003-91638004(-) m6A CDS       24284625//24981863//26404942//22608085
chr8:91643815-91643816(-) m6A CDS//intron       24284625//22608085
chr8:91643838-91643839(-) m6A CDS//intron       24284625
chr8:91643887-91643888(-) m6A CDS//intron       24284625
chr8:91657810-91657811(-) m6A CDS//intron       25456834//27773536
chr8:91658002-91658003(-) m6A CDS//intron       24209618//27773536
chr8:91658214-91658215(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr8:91696125-91696126(-) m6A exon//intron       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-15a-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TMEM64
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-15a-3p
Lenalidomide 216326 Drug interaction    RC00006799
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-15a-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       20162574

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-15a-3p
Interactor2: TMEM64

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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