Basic Information:

  VIRBase ID:  

HHID00062645

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:  MIMAT0004487          SENP2:  NM_021627     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-2-3p	SENP2
miRBase Accession/Entrez ID	MIMAT0004487	59343
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AXAM2//SMT3IP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-2-3p	rs1556935827 chrX:53557203    C/G rs1556935837 chrX:53557205    G/A rs782106021 chrX:53557206    T/C rs781874809 chrX:53557216    A/G rs782760005 chrX:53557211    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SENP2	chr3:185309269(+) A-I      intronic chr3:185308842(+) A-I      intronic chr3:185308767(+) A-I      intronic chr3:185308413(+) A-I      intronic chr3:185308215(+) A-I      intronic chr3:185308157(+) A-I      intronic chr3:185308150(+) A-I      intronic chr3:185308107(+) A-I      intronic chr3:185347213(+) A-I      intronic chr3:185328619(+) A-I      intronic chr3:185347203(+) A-I      intronic chr3:185341032(+) A-I      intronic chr3:185341030(+) A-I      intronic chr3:185342485(+) A-I      intronic chr3:185313689(+) A-I      intronic chr3:185316029(+) A-I      intronic chr3:185308176(+) A-I      intronic chr3:185308160(+) A-I      intronic chr3:185308159(+) A-I      intronic chr3:185311070(+) A-I      intronic chr3:185311078(+) A-I      intronic chr3:185311603(+) A-I      intronic chr3:185311646(+) A-I      intronic chr3:185311726(+) A-I      intronic chr3:185312701(+) A-I      intronic chr3:185312759(+) A-I      intronic chr3:185313608(+) A-I      intronic chr3:185313634(+) A-I      intronic chr3:185347204(+) A-I      intronic chr3:185313750(+) A-I      intronic chr3:185313763(+) A-I      intronic chr3:185314014(+) A-I      intronic chr3:185314369(+) A-I      intronic chr3:185314396(+) A-I      intronic chr3:185342486(+) A-I      intronic chr3:185342545(+) A-I      intronic chr3:185347187(+) A-I      intronic chr3:185313724(+) A-I      intronic chr3:185314735(+) A-I      intronic chr3:185315498(+) A-I      intronic chr3:185315519(+) A-I      intronic chr3:185328696(+) A-I      intronic chr3:185345270(+) A-I      intronic chr3:185346541(+) A-I      intronic chr3:185315900(+) A-I      intronic chr3:185315913(+) A-I      intronic chr3:185316041(+) A-I      intronic chr3:185309996(+) A-I      intronic chr3:185320570(+) A-I      intronic chr3:185321805(+) A-I      intronic chr3:185322998(+) A-I      intronic chr3:185322999(+) A-I      intronic chr3:185323000(+) A-I      intronic chr3:185323002(+) A-I      intronic chr3:185323142(+) A-I      intronic chr3:185328018(+) A-I      intronic chr3:185328048(+) A-I      intronic chr3:185328053(+) A-I      intronic chr3:185328542(+) A-I      intronic chr3:185329020(+) A-I      intronic chr3:185329047(+) A-I      intronic chr3:185334006(+) A-I      intronic chr3:185334045(+) A-I      intronic chr3:185334107(+) A-I      intronic chr3:185334246(+) A-I      intronic chr3:185334380(+) A-I      intronic chr3:185334507(+) A-I      intronic chr3:185334523(+) A-I      intronic chr3:185335819(+) A-I      intronic chr3:185335906(+) A-I      intronic chr3:185335932(+) A-I      intronic chr3:185336599(+) A-I      intronic chr3:185336608(+) A-I      intronic chr3:185337540(+) A-I      intronic chr3:185337595(+) A-I      intronic chr3:185338075(+) A-I      intronic chr3:185338697(+) A-I      intronic chr3:185340668(+) A-I      intronic chr3:185340705(+) A-I      intronic chr3:185340805(+) A-I      intronic chr3:185341504(+) A-I      intronic chr3:185342477(+) A-I      intronic chr3:185342549(+) A-I      intronic chr3:185342597(+) A-I      intronic chr3:185342608(+) A-I      intronic chr3:185342963(+) A-I      intronic chr3:185343106(+) A-I      intronic chr3:185344299(+) A-I      intronic chr3:185344360(+) A-I      intronic chr3:185344385(+) A-I      intronic chr3:185344441(+) A-I      intronic chr3:185346001(+) A-I      intronic chr3:185346006(+) A-I      intronic chr3:185346105(+) A-I      intronic chr3:185346108(+) A-I      intronic chr3:185346127(+) A-I      intronic chr3:185346147(+) A-I      intronic chr3:185346375(+) A-I      intronic chr3:185346436(+) A-I      intronic chr3:185347179(+) A-I      intronic chr3:185347251(+) A-I      intronic chr3:185347291(+) A-I      intronic chr3:185347314(+) A-I      intronic chr3:185347366(+) A-I      intronic chr3:185308792(+) A-I      intronic chr3:185309204(+) A-I      intronic chr3:185337707(+) A-I      intronic chr3:185308248(+) A-I      intronic chr3:185314226(+) A-I      intronic chr3:185346359(+) A-I      intronic chr3:185309710(+) A-I      intronic chr3:185346199(+) A-I      intronic chr3:185344755(+) A-I      intronic chr3:185328589(+) A-I      intronic chr3:185314026(+) A-I      intronic chr3:185323150(+) A-I      intronic chr3:185308468(+) A-I      intronic chr3:185341471(+) A-I      intronic chr3:185347163(+) A-I      intronic chr3:185314329(+) A-I      intronic chr3:185341070(+) A-I      intronic chr3:185333354(+) A-I      intronic chr3:185328133(+) A-I      intronic chr3:185328904(+) A-I      intronic chr3:185308286(+) A-I      intronic chr3:185314851(+) A-I      intronic chr3:185314324(+) A-I      intronic chr3:185334149(+) A-I      intronic chr3:185313714(+) A-I      intronic chr3:185342014(+) A-I      intronic chr3:185314834(+) A-I      intronic chr3:185335755(+) A-I      intronic chr3:185331437(+) A-I      intronic chr3:185346434(+) A-I      intronic chr3:185338865(+) A-I      intronic chr3:185314767(+) A-I      intronic chr3:185314266(+) A-I      intronic chr3:185308189(+) A-I      intronic chr3:185346474(+) A-I      intronic chr3:185341401(+) A-I      intronic chr3:185314839(+) A-I      intronic chr3:185344743(+) A-I      intronic chr3:185315859(+) A-I      intronic chr3:185309936(+) A-I      intronic chr3:185328888(+) A-I      intronic chr3:185337951(+) A-I      intronic chr3:185308900(+) A-I      intronic chr3:185308177(+) A-I      intronic chr3:185328587(+) A-I      intronic chr3:185346425(+) A-I      intronic chr3:185308526(+) A-I      intronic chr3:185310588(+) A-I      intronic chr3:185334106(+) A-I      intronic chr3:185345980(+) A-I      intronic chr3:185328586(+) A-I      intronic chr3:185334309(+) A-I      intronic chr3:185347298(+) A-I      intronic chr3:185328012(+) A-I      intronic chr3:185347235(+) A-I      intronic chr3:185328049(+) A-I      intronic chr3:185313854(+) A-I      intronic chr3:185338848(+) A-I      intronic chr3:185342402(+) A-I      intronic chr3:185342535(+) A-I      intronic chr3:185344742(+) A-I      intronic chr3:185346516(+) A-I      intronic chr3:185346064(+) A-I      intronic chr3:185346054(+) A-I      intronic chr3:185350369(+) A-I      3'UTR chr3:185350283(+) A-I      3'UTR chr3:185350285(+) A-I      3'UTR chr3:185346351(+) A-I      intronic chr3:185309321(+) A-I      intronic chr3:185328224(+) A-I      intronic chr3:185308393(+) A-I      intronic chr3:185333675(+) A-I      intronic chr3:185344450(+) A-I      intronic chr3:185342465(+) A-I      intronic chr3:185315676(+) A-I      intronic chr3:185347164(+) A-I      intronic chr3:185320464(+) A-I      intronic chr3:185309338(+) A-I      intronic chr3:185344788(+) A-I      intronic chr3:185341055(+) A-I      intronic chr3:185328625(+) A-I      intronic chr3:185328150(+) A-I      intronic chr3:185346051(+) A-I      intronic chr3:185308528(+) A-I      intronic chr3:185320463(+) A-I      intronic chr3:185335796(+) A-I      intronic chr3:185314711(+) A-I      intronic chr3:185328927(+) A-I      intronic chr3:185308467(+) A-I      intronic chr3:185338855(+) A-I      intronic chr3:185342478(+) A-I      intronic chr3:185328979(+) A-I      intronic chr3:185342408(+) A-I      intronic chr3:185328585(+) A-I      intronic chr3:185338079(+) A-I      intronic chr3:185311752(+) A-I      intronic chr3:185320457(+) A-I      intronic chr3:185309713(+) A-I      intronic chr3:185341058(+) A-I      intronic chr3:185346394(+) A-I      intronic chr3:185328490(+) A-I      intronic chr3:185314807(+) A-I      intronic chr3:185334138(+) A-I      intronic chr3:185331513(+) A-I      intronic chr3:185333332(+) A-I      intronic chr3:185311176(+) A-I      intronic chr3:185346187(+) A-I      intronic chr3:185307730(+) A-I      intronic chr3:185328599(+) A-I      intronic chr3:185344688(+) A-I      intronic chr3:185314262(+) A-I      intronic chr3:185320479(+) A-I      intronic chr3:185338870(+) A-I      intronic chr3:185328984(+) A-I      intronic chr3:185308285(+) A-I      intronic chr3:185342510(+) A-I      intronic chr3:185341047(+) A-I      intronic chr3:185347239(+) A-I      intronic chr3:185313934(+) A-I      intronic chr3:185336546(+) A-I      intronic chr3:185314153(+) A-I      intronic chr3:185341435(+) A-I      intronic chr3:185314315(+) A-I      intronic chr3:185342533(+) A-I      intronic chr3:185344817(+) A-I      intronic chr3:185314146(+) A-I      intronic chr3:185313675(+) A-I      intronic chr3:185346395(+) A-I      intronic chr3:185308216(+) A-I      intronic chr3:185316004(+) A-I      intronic chr3:185315571(+) A-I      intronic chr3:185320466(+) A-I      intronic chr3:185315220(+) A-I      intronic chr3:185333232(+) A-I      intronic chr3:185334179(+) A-I      intronic chr3:185311100(+) A-I      intronic chr3:185342559(+) A-I      intronic chr3:185338287(+) A-I      intronic chr3:185310485(+) A-I      intronic chr3:185308158(+) A-I      intronic chr3:185318887(+) A-I      intronic chr3:185328694(+) A-I      intronic chr3:185346090(+) A-I      intronic chr3:185320543(+) A-I      intronic chr3:185314745(+) A-I      intronic chr3:185345301(+) A-I      intronic chr3:185320542(+) A-I      intronic chr3:185313653(+) A-I      intronic chr3:185335837(+) A-I      intronic chr3:185346024(+) A-I      intronic chr3:185347181(+) A-I      intronic chr3:185309970(+) A-I      intronic chr3:185344283(+) A-I      intronic chr3:185308205(+) A-I      intronic chr3:185337931(+) A-I      intronic chr3:185314783(+) A-I      intronic chr3:185346018(+) A-I      intronic chr3:185338964(+) A-I      intronic chr3:185338669(+) A-I      intronic chr3:185308569(+) A-I      intronic chr3:185320885(+) A-I      intronic chr3:185334148(+) A-I      intronic chr3:185314179(+) A-I      intronic chr3:185328147(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SENP2	chr3:185338718(+) A-I intron -    22327324 chr3:185320446(+) A-I intron -    21960545 chr3:185308468(+) A-G intron -    22484847 chr3:185308526(+) A-G intron -    22484847 chr3:185308528(+) A-G intron -    22484847 chr3:185308569(+) A-G intron -    22484847 chr3:185308792(+) A-G intron -    22484847 chr3:185308858(+) A-G intron -    22484847 chr3:185308900(+) A-G intron -    22484847 chr3:185309338(+) A-G intron -    22484847 chr3:185309346(+) A-G intron -    22484847 chr3:185309936(+) A-G intron -    22484847 chr3:185309970(+) A-G intron -    22484847 chr3:185310588(+) A-G intron -    22484847 chr3:185311100(+) A-G intron -    22484847 chr3:185313653(+) A-G intron -    22484847 chr3:185313682(+) G-A intron -    22484847 chr3:185313714(+) A-G intron -    22484847 chr3:185313854(+) A-G intron -    22484847 chr3:185313934(+) A-G intron -    22484847 chr3:185314130(+) A-G intron -    22484847 chr3:185314146(+) A-G intron -    22484847 chr3:185314153(+) A-G intron -    22484847 chr3:185314179(+) A-G intron -    22484847 chr3:185314226(+) A-G intron -    22484847 chr3:185314262(+) A-G intron -    22484847 chr3:185314266(+) A-G intron -    22484847 chr3:185314302(+) A-G intron -    22484847 chr3:185314315(+) A-G intron -    22484847 chr3:185314682(+) T-C intron -    22484847 chr3:185314711(+) A-G intron -    22484847 chr3:185314745(+) A-G intron -    22484847 chr3:185314834(+) A-G intron -    22484847 chr3:185314839(+) A-G intron -    22484847 chr3:185315647(+) A-G intron -    22484847 chr3:185315676(+) A-G intron -    22484847 chr3:185318887(+) A-G intron -    22484847 chr3:185320457(+) A-G intron -    22484847 chr3:185320463(+) A-G intron -    22484847 chr3:185320479(+) A-G intron -    22484847 chr3:185321648(+) A-G intron -    22484847 chr3:185322993(+) A-G intron -    22484847 chr3:185328202(+) A-G intron -    22484847 chr3:185328484(+) A-G intron -    22484847 chr3:185328490(+) A-G intron -    22484847 chr3:185328491(+) A-G intron -    22484847 chr3:185328585(+) A-G intron -    22484847 chr3:185328586(+) A-G intron -    22484847 chr3:185328625(+) A-G intron -    22484847 chr3:185328694(+) A-G intron -    22484847 chr3:185328887(+) A-G intron -    22484847 chr3:185333332(+) A-G intron -    22484847 chr3:185334139(+) A-G intron -    22484847 chr3:185335755(+) A-G intron -    22484847 chr3:185335796(+) A-G intron -    22484847 chr3:185335797(+) A-G intron -    22484847 chr3:185335837(+) A-G intron -    22484847 chr3:185336546(+) A-G intron -    22484847 chr3:185338287(+) A-G intron -    22484847 chr3:185338505(+) A-G intron -    22484847 chr3:185338718(+) A-G intron -    22484847 chr3:185340674(+) A-G intron -    22484847 chr3:185341070(+) A-G intron -    22484847 chr3:185342402(+) A-G intron -    22484847 chr3:185345944(+) A-G intron -    22484847 chr3:185346007(+) A-G intron -    22484847 chr3:185346018(+) A-G intron -    22484847 chr3:185346024(+) A-G intron -    22484847 chr3:185346054(+) A-G intron -    22484847 chr3:185346064(+) A-G intron -    22484847 chr3:185346090(+) A-G intron -    22484847 chr3:185346199(+) A-G intron -    22484847 chr3:185346359(+) A-G intron -    22484847 chr3:185346364(+) A-G intron -    22484847 chr3:185346394(+) A-G intron -    22484847 chr3:185346398(+) A-G intron -    22484847 chr3:185346425(+) A-G intron -    22484847 chr3:185346545(+) T-C intron -    22484847 chr3:185347163(+) A-G intron -    22484847 chr3:185347181(+) A-G intron -    22484847 chr3:185347218(+) A-G intron -    22484847 chr3:185347239(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SENP2	chr3:185304098-185304099(+) m6A 5'UTR//intron       24981863 chr3:185324204-185324205(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:185324213-185324214(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:185327104-185327105(+) m6A 3'UTR//CDS//exon       24981863 chr3:185329458-185329459(+) m6A 3'UTR//CDS//exon       24981863 chr3:185329469-185329470(+) m6A 3'UTR//CDS//exon       24981863 chr3:185329508-185329509(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:185329528-185329529(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:185332459-185332460(+) m6A 3'UTR//CDS//exon       24981863 chr3:185332493-185332494(+) m6A 3'UTR//CDS//exon       24981863 chr3:185332518-185332519(+) m6A 3'UTR//CDS//exon       24981863 chr3:185347636-185347637(+) m6A 3'UTR       24284625//24981863//22608085 chr3:185347638-185347639(+) Y 3'UTR       26075521 chr3:185347677-185347678(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr3:185347854-185347855(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr3:185347874-185347875(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr3:185348003-185348004(+) m6A 3'UTR       24209618//22608085 chr3:185348066-185348067(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr3:185348128-185348129(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr3:185348321-185348322(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:185348329-185348330(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:185348343-185348344(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr3:185348363-185348364(+) Y 3'UTR       26075521 chr3:185348394-185348395(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr3:185348436-185348437(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:185348466-185348467(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr3:185348508-185348509(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SENP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-2-3p
Interactor2: SENP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.