Detail Information

Basic Information:


  VIRBase ID:  

HHID00062633

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:           RAD18:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-2-3p RAD18
miRBase
Accession/Entrez ID		 MIMAT0004487 56852
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RNF73

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-2-3p
rs1556935827 chrX:53557203    C/G
rs1556935837 chrX:53557205    G/A
rs782106021 chrX:53557206    T/C
rs781874809 chrX:53557216    A/G
rs782760005 chrX:53557211    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAD18
chr3:8939637(-) A-I      intronic
chr3:8956633(-) A-I      intronic
chr3:8956725(-) A-I      intronic
chr3:8956733(-) A-I      intronic
chr3:8956781(-) A-I      intronic
chr3:8957412(-) A-I      intronic
chr3:8971463(-) A-I      intronic
chr3:8939497(-) A-I      intronic
chr3:8956709(-) A-I      intronic
chr3:8956721(-) A-I      intronic
chr3:8936596(-) A-I      intronic
chr3:8956711(-) A-I      intronic
chr3:8956578(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RAD18
chr3:8956711(-) A-G intron -    22484847
chr3:8956721(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAD18
chr3:8918869-8918870(-) m6A 3'UTR//intron       27773535
chr3:8918926-8918927(-) m6A 3'UTR//intron       27773535
chr3:8918956-8918957(-) m6A 3'UTR//intron       27773535
chr3:8919004-8919005(-) m6A 3'UTR//intron       27773535
chr3:8919029-8919030(-) m6A 3'UTR//intron       27773535
chr3:8919589-8919590(-) m6A 3'UTR//intron       27773535
chr3:8919706-8919707(-) m6A 3'UTR//intron       27773535
chr3:8919822-8919823(-) m6A 3'UTR//intron       27773535
chr3:8919938-8919939(-) m6A 3'UTR//intron       27773535
chr3:8919995-8919996(-) m6A 3'UTR//intron       27773535
chr3:8920015-8920016(-) m6A 3'UTR//intron       27773535
chr3:8920027-8920028(-) m6A 3'UTR//intron       27773535
chr3:8920090-8920091(-) m6A 3'UTR//intron       27773535
chr3:8920104-8920105(-) m6A 3'UTR//intron       27773535
chr3:8920142-8920143(-) m6A 3'UTR//intron       27773535
chr3:8922047-8922048(-) m6A 3'UTR//intron       -
chr3:8923059-8923060(-) m6A 3'UTR//CDS//intron       24284625//24981863
chr3:8923067-8923068(-) m6A 3'UTR//CDS//intron       24284625//24981863
chr3:8923109-8923110(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr3:8923128-8923129(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr3:8944120-8944121(-) m6A 3'UTR//CDS//exon       24981863
chr3:8944196-8944197(-) m6A 3'UTR//CDS//exon       24981863
chr3:8983252-8983253(-) Am 3'UTR//CDS//exon       -
chr3:9005064-9005065(-) m6A CDS//exon       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-2-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
RAD18
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-2-3p
Interactor2: RAD18

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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