Basic Information:

  VIRBase ID:  

HHID00062625

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:  MIMAT0004487          CHD7:  NM_017780     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-2-3p	CHD7
miRBase Accession/Entrez ID	MIMAT0004487	55636
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CRG//HH5//IS3//KAL5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-2-3p	rs1556935827 chrX:53557203    C/G rs1556935837 chrX:53557205    G/A rs782106021 chrX:53557206    T/C rs781874809 chrX:53557216    A/G rs782760005 chrX:53557211    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CHD7	chr8:61625489(+) A-I      intronic chr8:61661810(+) A-I      intronic chr8:61625931(+) A-I      intronic chr8:61625490(+) A-I      intronic chr8:61771241(+) A-I      intronic chr8:61771308(+) A-I      intronic chr8:61657285(+) A-I      intronic chr8:61657321(+) A-I      intronic chr8:61658626(+) A-I      intronic chr8:61658657(+) A-I      intronic chr8:61659684(+) A-I      intronic chr8:61659898(+) A-I      intronic chr8:61661720(+) A-I      intronic chr8:61661770(+) A-I      intronic chr8:61661850(+) A-I      intronic chr8:61661851(+) A-I      intronic chr8:61771223(+) A-I      intronic chr8:61659739(+) A-I      intronic chr8:61659716(+) A-I      intronic chr8:61625425(+) A-I      intronic chr8:61669234(+) A-I      intronic chr8:61719504(+) A-I      intronic chr8:61661815(+) A-I      intronic chr8:61771366(+) A-I      intronic chr8:61700620(+) A-I      intronic chr8:61625516(+) A-I      intronic chr8:61659774(+) A-I      intronic chr8:61661748(+) A-I      intronic chr8:61625463(+) A-I      intronic chr8:61771246(+) A-I      intronic chr8:61771389(+) A-I      intronic chr8:61658732(+) A-I      intronic chr8:61771279(+) A-I      intronic chr8:61657252(+) A-I      intronic chr8:61625855(+) A-I      intronic chr8:61661754(+) A-I      intronic chr8:61625695(+) A-I      intronic chr8:61661833(+) A-I      intronic chr8:61641141(+) A-I      intronic chr8:61670788(+) A-I      intronic chr8:61625548(+) A-I      intronic chr8:61659764(+) A-I      intronic chr8:61625810(+) A-I      intronic chr8:61661769(+) A-I      intronic chr8:61625874(+) A-I      intronic chr8:61670807(+) A-I      intronic chr8:61771220(+) A-I      intronic chr8:61725155(+) A-I      intronic chr8:61776371(+) A-I      intronic chr8:61625514(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CHD7	chr8:61677763(+) T-C intron -    22484847 chr8:61625425(+) A-G intron -    22484847 chr8:61625514(+) A-G intron -    22484847 chr8:61625751(+) A-G intron -    22484847 chr8:61625855(+) A-G intron -    22484847 chr8:61625874(+) A-G intron -    22484847 chr8:61658619(+) A-G intron -    22484847 chr8:61658686(+) A-G intron -    22484847 chr8:61659764(+) A-G intron -    22484847 chr8:61659774(+) A-G intron -    22484847 chr8:61661748(+) A-G intron -    22484847 chr8:61661769(+) A-G intron -    22484847 chr8:61661774(+) A-G intron -    22484847 chr8:61661815(+) A-G intron -    22484847 chr8:61661833(+) A-G intron -    22484847 chr8:61669147(+) G-A intron -    22484847 chr8:61771220(+) A-G intron -    22484847 chr8:61771389(+) A-G intron -    22484847 chr8:61776825(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CHD7	chr8:61591414-61591415(+) m6A 5'UTR       24284625//24981863 chr8:61591427-61591428(+) m6A 5'UTR       24284625//24981863 chr8:61591481-61591482(+) m6A 5'UTR       24284625//24981863 chr8:61591487-61591488(+) m6A 5'UTR       24284625//24981863 chr8:61591497-61591498(+) m6A 5'UTR       24284625//24981863 chr8:61591508-61591509(+) m6A 5'UTR       24284625//24981863 chr8:61592334-61592335(+) m6A 5'UTR//intron       - chr8:61653830-61653831(+) m6A 5'UTR       24981863 chr8:61653921-61653922(+) m6A 5'UTR       24981863//22608085 chr8:61654121-61654122(+) m6A CDS       24284625//24981863//26404942//22608085 chr8:61654180-61654181(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr8:61654218-61654219(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr8:61654250-61654251(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr8:61654281-61654282(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr8:61654409-61654410(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61654451-61654452(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr8:61654683-61654684(+) m6A CDS//intron       24284625 chr8:61654855-61654856(+) m6A CDS//intron       24284625 chr8:61654882-61654883(+) m6A CDS//intron       24284625 chr8:61654904-61654905(+) m6A CDS//intron       24284625 chr8:61655057-61655058(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:61655070-61655071(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:61655120-61655121(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:61655128-61655129(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:61655155-61655156(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:61655328-61655329(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61655351-61655352(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61655450-61655451(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr8:61655627-61655628(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr8:61693587-61693588(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr8:61693617-61693618(+) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr8:61693665-61693666(+) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr8:61693700-61693701(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr8:61693776-61693777(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27773536//22608085 chr8:61693787-61693788(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27773536//22608085 chr8:61693847-61693848(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693857-61693858(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693866-61693867(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693893-61693894(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693900-61693901(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693951-61693952(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61693965-61693966(+) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr8:61707553-61707554(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//27773535//22608085 chr8:61707602-61707603(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr8:61707624-61707625(+) m6A 3'UTR//CDS//intron       - chr8:61707630-61707631(+) m6A 3'UTR//CDS//intron       - chr8:61707635-61707636(+) m6A 3'UTR//CDS//intron       - chr8:61707672-61707673(+) m6A 3'UTR//CDS//intron       - chr8:61712963-61712964(+) m6A 3'UTR//CDS//intron       - chr8:61720827-61720828(+) m6A CDS//intron       24981863//27773535 chr8:61729043-61729044(+) m6A CDS//intron       24981863 chr8:61732617-61732618(+) m6A CDS//intron       24981863 chr8:61734394-61734395(+) m6A CDS//intron       24981863 chr8:61734418-61734419(+) m6A CDS//intron       24981863 chr8:61734452-61734453(+) m6A CDS//intron       24981863 chr8:61734474-61734475(+) m6A CDS//intron       24981863 chr8:61736537-61736538(+) m6A CDS//intron       25456834 chr8:61736556-61736557(+) m6A CDS//intron       25456834 chr8:61736570-61736571(+) m6A CDS//intron       25456834 chr8:61736604-61736605(+) m6A CDS//intron       25456834 chr8:61742947-61742948(+) m6A CDS//intron       24981863 chr8:61742967-61742968(+) m6A CDS//intron       24981863 chr8:61750333-61750334(+) m6A CDS//intron       24981863 chr8:61757931-61757932(+) m6A CDS//intron       24981863 chr8:61757944-61757945(+) m6A CDS//intron       24981863 chr8:61763152-61763153(+) m6A CDS//intron       24981863 chr8:61763616-61763617(+) m6A CDS//exon//intron       24981863 chr8:61763629-61763630(+) m6A CDS//exon//intron       24981863 chr8:61763639-61763640(+) m6A CDS//exon//intron       24981863 chr8:61764720-61764721(+) m6A CDS//exon//intron       24981863 chr8:61765060-61765061(+) m6A CDS//exon//intron       24981863 chr8:61765443-61765444(+) m6A CDS//intron       24284625//22608085 chr8:61765579-61765580(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61765601-61765602(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61765672-61765673(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr8:61765684-61765685(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr8:61765714-61765715(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr8:61765740-61765741(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr8:61765790-61765791(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:61765822-61765823(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:61765864-61765865(+) m1A CDS//intron       26863196 chr8:61765869-61765870(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:61765934-61765935(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr8:61765960-61765961(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr8:61766030-61766031(+) Tm CDS//intron       - chr8:61767763-61767764(+) m6A exon//intron       - chr8:61768549-61768550(+) m6A CDS//exon//intron       - chr8:61768558-61768559(+) m6A CDS//exon//intron       - chr8:61768660-61768661(+) m6A CDS//exon//intron       - chr8:61769149-61769150(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr8:61769276-61769277(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22608085 chr8:61769287-61769288(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22608085 chr8:61769401-61769402(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr8:61773504-61773505(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr8:61773520-61773521(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr8:61773536-61773537(+) m6A CDS//exon//intron       24284625//25456834//24981863 chr8:61773544-61773545(+) m6A CDS//exon//intron       24284625//25456834//24981863 chr8:61773550-61773551(+) m6A CDS//exon//intron       24284625//25456834//24981863 chr8:61775185-61775186(+) m6A CDS//exon       - chr8:61775190-61775191(+) m6A CDS//exon       - chr8:61777737-61777738(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr8:61777758-61777759(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61777831-61777832(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61777869-61777870(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61777974-61777975(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778002-61778003(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778010-61778011(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778058-61778059(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778064-61778065(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778154-61778155(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778233-61778234(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:61778275-61778276(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr8:61778332-61778333(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:61778351-61778352(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:61778390-61778391(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:61778442-61778443(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:61778472-61778473(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:61778522-61778523(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr8:61779243-61779244(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	CHD7	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-2-3p
Interactor2: CHD7

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.