Detail Information

Basic Information:


  VIRBase ID:  

HHID00062539

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:           LRP8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-2-3p LRP8
miRBase
Accession/Entrez ID		 MIMAT0004487 7804
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - APOER2//HSZ75190//LRP-8//MCI1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-2-3p
rs1556935827 chrX:53557203    C/G
rs1556935837 chrX:53557205    G/A
rs782106021 chrX:53557206    T/C
rs781874809 chrX:53557216    A/G
rs782760005 chrX:53557211    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP8
chr1:53767666(-) A-I      intronic
chr1:53768294(-) A-I      intronic
chr1:53768346(-) A-I      intronic
chr1:53768353(-) A-I      intronic
chr1:53712524(-) A-I      3'UTR
chr1:53767614(-) A-I      intronic
chr1:53767522(-) A-I      intronic
chr1:53767402(-) A-I      intronic
chr1:53767397(-) A-I      intronic
chr1:53767320(-) A-I      intronic
chr1:53717450(-) A-I      intronic
chr1:53717459(-) A-I      intronic
chr1:53768482(-) A-I      intronic
chr1:53728625(-) A-I      intronic
chr1:53767291(-) A-I      intronic
chr1:53789871(-) A-I      intronic
chr1:53714222(-) A-I      intronic
chr1:53712950(-) A-I      intronic
chr1:53767505(-) A-I      intronic
chr1:53767680(-) A-I      intronic
chr1:53713182(-) A-I      intronic
chr1:53735082(-) A-I      intronic
chr1:53767444(-) A-I      intronic
chr1:53789874(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LRP8
chr1:53712950(-) A-G intron -    22484847
chr1:53717972(-) G-A intron -    22484847
chr1:53732972(-) A-G intron -    22484847
chr1:53733060(-) A-G intron -    22484847
chr1:53733156(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP8
chr1:53708443-53708444(-) m6A 3'UTR       27773535
chr1:53708461-53708462(-) m6A 3'UTR       27773535
chr1:53708474-53708475(-) m6A 3'UTR       27773535
chr1:53709142-53709143(-) m6A 3'UTR       24981863//27773535
chr1:53709314-53709315(-) m6A 3'UTR       24981863//27773535
chr1:53709347-53709348(-) m6A 3'UTR       24981863//27773535
chr1:53709373-53709374(-) m6A 3'UTR       24981863//27773535
chr1:53709388-53709389(-) m6A 3'UTR       27773535
chr1:53709394-53709395(-) m6A 3'UTR       27773535
chr1:53709538-53709539(-) m6A 3'UTR       27773535
chr1:53709649-53709650(-) m6A 3'UTR       27773535
chr1:53709771-53709772(-) m6A 3'UTR       24981863//27773535//22608085
chr1:53709811-53709812(-) m6A 3'UTR       24981863//27773535//22608085
chr1:53709825-53709826(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709899-53709900(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709911-53709912(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53709930-53709931(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710003-53710004(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710030-53710031(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:53710165-53710166(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:53710212-53710213(-) m6A 3'UTR       -
chr1:53710285-53710286(-) m6A 3'UTR       -
chr1:53710339-53710340(-) m6A 3'UTR       -
chr1:53710391-53710392(-) m6A 3'UTR       -
chr1:53710444-53710445(-) m6A 3'UTR       -
chr1:53710476-53710477(-) m6A 3'UTR       -
chr1:53710495-53710496(-) m6A 3'UTR       -
chr1:53710596-53710597(-) m6A 3'UTR       -
chr1:53710610-53710611(-) m6A 3'UTR       -
chr1:53710659-53710660(-) m6A 3'UTR       -
chr1:53710753-53710754(-) m6A 3'UTR       -
chr1:53711225-53711226(-) m6A 3'UTR       27773535
chr1:53711345-53711346(-) m6A 3'UTR       27773535
chr1:53711368-53711369(-) m6A 3'UTR       -
chr1:53716390-53716391(-) m6A 3'UTR//CDS       24981863
chr1:53716432-53716433(-) m6A 3'UTR//CDS       24981863//27773535
chr1:53716473-53716474(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53716488-53716489(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53720844-53720845(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:53723016-53723017(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535
chr1:53723030-53723031(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723058-53723059(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723088-53723089(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr1:53723702-53723703(-) m6A exon//intron       24981863//27773535
chr1:53723716-53723717(-) m6A exon//intron       27773535
chr1:53724010-53724011(-) m6A 3'UTR//CDS//exon       27773535
chr1:53730056-53730057(-) m6A 3'UTR//CDS//exon       27773535
chr1:53732249-53732250(-) m6A 3'UTR//5'UTR//CDS//exon       27773535
chr1:53733619-53733620(-) m6A exon//intron       -
chr1:53736806-53736807(-) m6A 3'UTR//CDS//intron       27773535//22575960
chr1:53736907-53736908(-) m6A 3'UTR//5'UTR//CDS       27773535//22575960
chr1:53736915-53736916(-) m6A 3'UTR//5'UTR//CDS       27773535//22575960
chr1:53741340-53741341(-) m6A 5'UTR//CDS//intron       24209618
chr1:53741380-53741381(-) m6A 5'UTR//CDS//intron       24209618
chr1:53742386-53742387(-) m6A CDS//intron       24209618
chr1:53742539-53742540(-) m6A CDS//intron       24209618//27773536
chr1:53793068-53793069(-) m6A 5'UTR//intron       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-2-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
LRP8
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-2-3p
Interactor2: LRP8

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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