Basic Information:

  VIRBase ID:  

HHID00062492

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:  MIMAT0004487          E2F4:  NM_001950     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-2-3p	E2F4
miRBase Accession/Entrez ID	MIMAT0004487	1874
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	E2F-4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-2-3p	rs1556935827 chrX:53557203    C/G rs1556935837 chrX:53557205    G/A rs782106021 chrX:53557206    T/C rs781874809 chrX:53557216    A/G rs782760005 chrX:53557211    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	E2F4	chr16:67229200(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	E2F4	chr16:67226198-67226199(+) m6A CDS//exon       - chr16:67226757-67226758(+) m6A CDS//exon//intron       27773535 chr16:67226864-67226865(+) m6A exon//intron       - chr16:67226953-67226954(+) m6A CDS//exon//intron       24981863 chr16:67226972-67226973(+) Gm 3'UTR//CDS//exon//intron       - chr16:67227004-67227005(+) m6A 3'UTR//CDS//exon//intron       24981863 chr16:67227009-67227010(+) m6A 3'UTR//CDS//exon//intron       24981863 chr16:67227066-67227067(+) m6A 3'UTR//CDS//exon//intron       24981863 chr16:67231893-67231894(+) m6A exon//intron       - chr16:67231949-67231950(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232035-67232036(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232055-67232056(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232061-67232062(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232088-67232089(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232219-67232220(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:67232224-67232225(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863 chr16:67232317-67232318(+) m6A 3'UTR//exon       24284625 chr16:67232424-67232425(+) m6A 3'UTR//exon       24284625 chr16:67232538-67232539(+) m6A 3'UTR//exon       24284625 chr16:67232572-67232573(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-2-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	E2F4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-2-3p
Interactor2: E2F4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.