Detail Information

Basic Information:


  VIRBase ID:  

HHID00062490

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-2-3p:           DUSP2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-2-3p DUSP2
miRBase
Accession/Entrez ID		 MIMAT0004487 1844
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAC-1//PAC1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-2-3p
rs1556935827 chrX:53557203    C/G
rs1556935837 chrX:53557205    G/A
rs782106021 chrX:53557206    T/C
rs781874809 chrX:53557216    A/G
rs782760005 chrX:53557211    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DUSP2
chr2:96809210-96809211(-) m6A 3'UTR       26404942
chr2:96809266-96809267(-) m6A 3'UTR       26404942
chr2:96809333-96809334(-) m6A 3'UTR       26404942
chr2:96809363-96809364(-) m6A 3'UTR       24284625
chr2:96809507-96809508(-) m6A 3'UTR//exon       24284625//25456834//28052920//27371828
chr2:96809581-96809582(-) m6A CDS//exon       24284625//25456834
chr2:96809945-96809946(-) m6A CDS//exon       26404942
chr2:96810537-96810538(-) m6A CDS       -
chr2:96810542-96810543(-) m6A CDS       -
chr2:96810741-96810742(-) m6A CDS       -
chr2:96811001-96811002(-) m6A CDS       27371828
chr2:96811124-96811125(-) m6A 5'UTR       24209618//25456834//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-2-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
DUSP2
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-2-3p
Interactor2: DUSP2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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