Basic Information:

  VIRBase ID:  

HHID00062397

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-1-3p:  MIMAT0004486          WDR11:  NM_018117     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-1-3p	WDR11
miRBase Accession/Entrez ID	MIMAT0004486	55717
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BRWD2//DR11//HH14//SRI1//WDR15

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-1-3p	rs1242905594 chr9:94176409    C/T rs1440850304 chr9:94176429    C/T rs375140031 chr9:94176420    A/G rs778240668 chr9:94176418    C/A rs753257172 chr9:94176416    A/C rs753257172 chr9:94176416    A/G rs780673185 chr9:94176411    A/C rs780673185 chr9:94176411    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDR11	chr10:122627926(+) A-I      intronic chr10:122615940(+) A-I      intronic chr10:122640078(+) A-I      intronic chr10:122635086(+) A-I      intronic chr10:122649909(+) A-I      intronic chr10:122659216(+) A-I      intronic chr10:122635091(+) A-I      intronic chr10:122636975(+) A-I      intronic chr10:122635134(+) A-I      intronic chr10:122637010(+) A-I      intronic chr10:122627872(+) A-I      intronic chr10:122627929(+) A-I      intronic chr10:122637076(+) A-I      intronic chr10:122637063(+) A-I      intronic chr10:122627878(+) A-I      intronic chr10:122649906(+) A-I      intronic chr10:122627779(+) A-I      intronic chr10:122627790(+) A-I      intronic chr10:122659207(+) A-I      intronic chr10:122627694(+) A-I      intronic chr10:122659152(+) A-I      intronic chr10:122637072(+) A-I      intronic chr10:122627855(+) A-I      intronic chr10:122627688(+) A-I      intronic chr10:122636997(+) A-I      intronic chr10:122659109(+) A-I      intronic chr10:122659026(+) A-I      intronic chr10:122636978(+) A-I      intronic chr10:122627887(+) A-I      intronic chr10:122635094(+) A-I      intronic chr10:122627780(+) A-I      intronic chr10:122649811(+) A-I      intronic chr10:122629590(+) A-I      intronic chr10:122637075(+) A-I      intronic chr10:122635065(+) A-I      intronic chr10:122659148(+) A-I      intronic chr10:122637016(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR11	chr10:122610709-122610710(+) m6A 5'UTR       24981863 chr10:122610726-122610727(+) m6A 5'UTR       24981863 chr10:122610743-122610744(+) m6A 5'UTR       24981863 chr10:122610758-122610759(+) m6A 5'UTR       24981863 chr10:122610790-122610791(+) m6A 5'UTR       24981863 chr10:122610806-122610807(+) m6A 5'UTR       24981863 chr10:122610822-122610823(+) m6A 5'UTR//exon       24981863 chr10:122610853-122610854(+) m6A 5'UTR//exon       24981863 chr10:122610951-122610952(+) m6A CDS//exon       24981863 chr10:122611014-122611015(+) m6A 5'UTR//CDS//exon       24981863 chr10:122622203-122622204(+) m6A exon//intron       - chr10:122622213-122622214(+) m6A exon//intron       - chr10:122622279-122622280(+) m6A 5'UTR//CDS//exon//intron       - chr10:122665755-122665756(+) m6A 3'UTR//intron       - chr10:122665888-122665889(+) m6A 3'UTR//intron       - chr10:122665916-122665917(+) m6A 3'UTR//intron       - chr10:122665955-122665956(+) m6A 3'UTR//intron       - chr10:122666361-122666362(+) m6A 3'UTR//CDS//exon       - chr10:122666818-122666819(+) m6A exon//intron       - chr10:122666884-122666885(+) m6A exon//intron       - chr10:122667705-122667706(+) m6A exon//intron       24284625 chr10:122667830-122667831(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr10:122667863-122667864(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr10:122667869-122667870(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr10:122667946-122667947(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr10:122668071-122668072(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:122668115-122668116(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:122668175-122668176(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:122668209-122668210(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:122668356-122668357(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr10:122668970-122668971(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	WDR11	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-1-3p
Interactor2: WDR11

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.