Basic Information:

  VIRBase ID:  

HHID00062294

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-1-3p:  MIMAT0004486          RFX5:  NM_001379413     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-1-3p	RFX5
miRBase Accession/Entrez ID	MIMAT0004486	5993
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-1-3p	rs1242905594 chr9:94176409    C/T rs1440850304 chr9:94176429    C/T rs375140031 chr9:94176420    A/G rs778240668 chr9:94176418    C/A rs753257172 chr9:94176416    A/C rs753257172 chr9:94176416    A/G rs780673185 chr9:94176411    A/C rs780673185 chr9:94176411    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RFX5	chr1:151313129-151313130(-) m6A 3'UTR       27773535 chr1:151314683-151314684(-) m6A CDS//intron       27773535 chr1:151314731-151314732(-) m6A CDS//intron       27773535 chr1:151314755-151314756(-) m6A CDS//intron       27773535 chr1:151315008-151315009(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr1:151315215-151315216(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr1:151315240-151315241(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr1:151315271-151315272(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr1:151315297-151315298(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:151315327-151315328(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:151315333-151315334(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr1:151315629-151315630(-) m6A CDS       24284625//24981863//27773535//27371828//27773536 chr1:151315826-151315827(-) m6A CDS       24284625//24981863//27371828//27773536 chr1:151315860-151315861(-) m6A CDS       24284625//24981863//27371828//27773536 chr1:151315880-151315881(-) m6A CDS       24284625//24981863//27371828//27773536 chr1:151315907-151315908(-) m6A CDS       24284625//24981863//27371828//27773536 chr1:151318422-151318423(-) m6A CDS//exon       24284625//24981863//27773535//27371828 chr1:151318718-151318719(-) m6A CDS//exon       24284625//24981863//27773535//27371828 chr1:151318759-151318760(-) m6A CDS//exon       24284625//24981863//27773535//27371828 chr1:151318945-151318946(-) m6A 5'UTR//intron       24981863//27773535 chr1:151319064-151319065(-) m6A 5'UTR//exon       24284625//24981863//27773535 chr1:151319309-151319310(-) m6A 5'UTR//exon//intron       24284625//24981863//27773535 chr1:151319721-151319722(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	RFX5	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-1-3p
Interactor2: RFX5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.