Detail Information

Basic Information:


  VIRBase ID:  

HHID00062277

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-1-3p:           IL10:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7f-1-3p IL10
miRBase
Accession/Entrez ID		 MIMAT0004486 3586
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CSIF//GVHDS//IL-10//IL10A//TGIF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7f-1-3p
rs1242905594 chr9:94176409    C/T
rs1440850304 chr9:94176429    C/T
rs375140031 chr9:94176420    A/G
rs778240668 chr9:94176418    C/A
rs753257172 chr9:94176416    A/C
rs753257172 chr9:94176416    A/G
rs780673185 chr9:94176411    A/C
rs780673185 chr9:94176411    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL10
chr1:206941331(-) A-I      3'UTR

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7f-1-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
IL10
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7f-1-3p
Interactor2: IL10

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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