Basic Information:

  VIRBase ID:  

HHID00062276

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-1-3p:  MIMAT0004486          IFIT3:  NM_001289759     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-1-3p	IFIT3
miRBase Accession/Entrez ID	MIMAT0004486	3437
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CIG-49//cig41//GARG-49//IFI60//IFIT4//IRG2//ISG60//P60//RIG-G

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-1-3p	rs1242905594 chr9:94176409    C/T rs1440850304 chr9:94176429    C/T rs375140031 chr9:94176420    A/G rs778240668 chr9:94176418    C/A rs753257172 chr9:94176416    A/C rs753257172 chr9:94176416    A/G rs780673185 chr9:94176411    A/C rs780673185 chr9:94176411    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFIT3	chr10:91100152(+) A-I      3'UTR chr10:91100128(+) A-I      3'UTR chr10:91100161(+) A-I      3'UTR chr10:91100132(+) A-I      3'UTR chr10:91100172(+) A-I      3'UTR chr10:91100158(+) A-I      3'UTR chr10:91100153(+) A-I      3'UTR chr10:91095784(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFIT3	chr10:91087689-91087690(+) m6A 5'UTR       24981863 chr10:91087757-91087758(+) m6A 5'UTR       24981863 chr10:91087765-91087766(+) m6A 5'UTR       24981863 chr10:91087776-91087777(+) m6A 5'UTR       24981863 chr10:91087806-91087807(+) m6A 5'UTR       24981863 chr10:91087815-91087816(+) m6A 5'UTR       24981863 chr10:91092268-91092269(+) m6A 5'UTR//intron       24981863 chr10:91092291-91092292(+) m6A 5'UTR//intron       24981863 chr10:91092359-91092360(+) m6A 5'UTR//intron       - chr10:91092370-91092371(+) m6A 5'UTR//intron       - chr10:91098479-91098480(+) m6A CDS       - chr10:91098494-91098495(+) m6A CDS       - chr10:91098548-91098549(+) m6A CDS       - chr10:91098594-91098595(+) m6A CDS       - chr10:91098663-91098664(+) m6A CDS       24981863//27773535//22575960 chr10:91098707-91098708(+) m6A CDS       24981863//27773535//22575960 chr10:91098738-91098739(+) m6A CDS       24981863//27773535//22575960 chr10:91098774-91098775(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91098822-91098823(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91098844-91098845(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91098936-91098937(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91098978-91098979(+) m6A CDS       24209618//24981863//22575960 chr10:91099059-91099060(+) m6A CDS       24981863 chr10:91099132-91099133(+) m6A CDS       24981863 chr10:91099184-91099185(+) m6A CDS       24981863//22575960 chr10:91099197-91099198(+) m6A CDS       24981863//22575960 chr10:91099229-91099230(+) m6A CDS       24981863//27773535//22575960 chr10:91099281-91099282(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099358-91099359(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099386-91099387(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099447-91099448(+) m6A CDS       24981863//27773535//22575960 chr10:91099538-91099539(+) m6A CDS       24981863//27773535 chr10:91099610-91099611(+) m6A CDS       24981863//27773535 chr10:91099734-91099735(+) m6A CDS       24981863 chr10:91099880-91099881(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91099886-91099887(+) m6A 3'UTR       24209618//24981863//27773535//22575960 chr10:91099899-91099900(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr10:91099952-91099953(+) m6A 3'UTR       24209618//24981863//27773535//22575960 chr10:91100114-91100115(+) m6A 3'UTR       24209618//24981863 chr10:91100235-91100236(+) m6A 3'UTR       24981863 chr10:91100562-91100563(+) m6A 3'UTR       24981863//27773535 chr10:91100571-91100572(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	IFIT3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-1-3p
Interactor2: IFIT3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.