Detail Information

Basic Information:


  VIRBase ID:  

HHID00062239

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7a-3p:           C5orf51:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7a-3p C5orf51
miRBase
Accession/Entrez ID		 MIMAT0004481 285636
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7a-3p
rs1219969167 chr9:94176028    T/G
rs1399588338 chr9:94176027    G/A
rs1453867589 chr9:94176023    T/A
rs770208205 chr9:94176022    C/T
rs1265084977 chr22:46112817    T/C
rs372596018 chr22:46112808    T/C
rs1198423693 chr9:94176020    A/G
rs748585376 chr9:94176015    A/G
rs781681931 chr9:94176014    T/G
rs972845958 chr9:94176013    CTA/C
rs779353569 chr22:46112805    C/T
rs970921980 chr22:46112807    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR C5orf51
chr5:41914549(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase C5orf51
chr5:41917262-41917263(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:41917325-41917326(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:41917337-41917338(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:41917364-41917365(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:41917375-41917376(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:41917432-41917433(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr5:41917440-41917441(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr5:41917476-41917477(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr5:41917499-41917500(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr5:41917543-41917544(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr5:41917578-41917579(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr5:41917621-41917622(+) m6A 3'UTR//intron       24981863//22608085
chr5:41918518-41918519(+) m6A 3'UTR//intron       24981863
chr5:41921688-41921689(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
C5orf51
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7a-3p
Interactor2: C5orf51

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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